JPS57206619A - Preparation of alpha1-protease inhibitor - Google Patents

Preparation of alpha1-protease inhibitor

Info

Publication number
JPS57206619A
JPS57206619A JP56088839A JP8883981A JPS57206619A JP S57206619 A JPS57206619 A JP S57206619A JP 56088839 A JP56088839 A JP 56088839A JP 8883981 A JP8883981 A JP 8883981A JP S57206619 A JPS57206619 A JP S57206619A
Authority
JP
Japan
Prior art keywords
carrier
protease inhibitor
solution
inhibitor
plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56088839A
Other languages
Japanese (ja)
Inventor
Shinobu Hayakawa
Tetsuo Adachi
Yoshimasa Itou
Kazuyuki Hirano
Mamoru Sugiura
Haruji Sawaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maruko Pharmaceutical Co Ltd
Original Assignee
Maruko Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maruko Pharmaceutical Co Ltd filed Critical Maruko Pharmaceutical Co Ltd
Priority to JP56088839A priority Critical patent/JPS57206619A/en
Publication of JPS57206619A publication Critical patent/JPS57206619A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a remedy for acute pancreatitis, etc. in high purity, by adsorbing a human blood serum or plasma on a carrier having bonded α1-protease inhibitor antibody, and eluting the absorbed inhibitor with an alkaline solution.
CONSTITUTION: A human blood serum or plasma is adsorbed on a carrier having bonded α1-protease inhibitor antibody. "Sepharose " or a porous glass crosslinked with an alkylamine or allylamine derivative is preferably used as the carrier. The carrier is then eluted with an alkaline solution to give the aimed α1- protease inhibitor. A 0.01W1.0mol solution at a pH of 10W11.8 is preferably used as the eluting solution. The resultant inhibitor is useful for the treatment of the acute pancreatitis or pancreatic necrosis, and the danger of causing the allergic reaction is sligh due to the extract from a man.
COPYRIGHT: (C)1982,JPO&Japio
JP56088839A 1981-06-11 1981-06-11 Preparation of alpha1-protease inhibitor Pending JPS57206619A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56088839A JPS57206619A (en) 1981-06-11 1981-06-11 Preparation of alpha1-protease inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56088839A JPS57206619A (en) 1981-06-11 1981-06-11 Preparation of alpha1-protease inhibitor

Publications (1)

Publication Number Publication Date
JPS57206619A true JPS57206619A (en) 1982-12-18

Family

ID=13954119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56088839A Pending JPS57206619A (en) 1981-06-11 1981-06-11 Preparation of alpha1-protease inhibitor

Country Status (1)

Country Link
JP (1) JPS57206619A (en)

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