JPS57206619A - Preparation of alpha1-protease inhibitor - Google Patents
Preparation of alpha1-protease inhibitorInfo
- Publication number
- JPS57206619A JPS57206619A JP56088839A JP8883981A JPS57206619A JP S57206619 A JPS57206619 A JP S57206619A JP 56088839 A JP56088839 A JP 56088839A JP 8883981 A JP8883981 A JP 8883981A JP S57206619 A JPS57206619 A JP S57206619A
- Authority
- JP
- Japan
- Prior art keywords
- carrier
- protease inhibitor
- solution
- inhibitor
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a remedy for acute pancreatitis, etc. in high purity, by adsorbing a human blood serum or plasma on a carrier having bonded α1-protease inhibitor antibody, and eluting the absorbed inhibitor with an alkaline solution.
CONSTITUTION: A human blood serum or plasma is adsorbed on a carrier having bonded α1-protease inhibitor antibody. "Sepharose " or a porous glass crosslinked with an alkylamine or allylamine derivative is preferably used as the carrier. The carrier is then eluted with an alkaline solution to give the aimed α1- protease inhibitor. A 0.01W1.0mol solution at a pH of 10W11.8 is preferably used as the eluting solution. The resultant inhibitor is useful for the treatment of the acute pancreatitis or pancreatic necrosis, and the danger of causing the allergic reaction is sligh due to the extract from a man.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56088839A JPS57206619A (en) | 1981-06-11 | 1981-06-11 | Preparation of alpha1-protease inhibitor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56088839A JPS57206619A (en) | 1981-06-11 | 1981-06-11 | Preparation of alpha1-protease inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57206619A true JPS57206619A (en) | 1982-12-18 |
Family
ID=13954119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56088839A Pending JPS57206619A (en) | 1981-06-11 | 1981-06-11 | Preparation of alpha1-protease inhibitor |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57206619A (en) |
-
1981
- 1981-06-11 JP JP56088839A patent/JPS57206619A/en active Pending
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