JPS57197213A - Orally administrable preparation of anticoagulant - Google Patents
Orally administrable preparation of anticoagulantInfo
- Publication number
- JPS57197213A JPS57197213A JP8063081A JP8063081A JPS57197213A JP S57197213 A JPS57197213 A JP S57197213A JP 8063081 A JP8063081 A JP 8063081A JP 8063081 A JP8063081 A JP 8063081A JP S57197213 A JPS57197213 A JP S57197213A
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- decomposition
- heparin
- mixture
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
PURPOSE:To obtain an oral agent for the remedy of thrombosis, etc., absorbable through the epithelial cells of small intestine in high efficiency, preventing the decomposition of antithrombin factors, by encapsulating an aqueous solution of a mixture of heparin and antithrombin III in liposome. CONSTITUTION:An aqueous solution of a mixture of heparin and antithrombin III is encapsulated in liposome. Preferably, the solution is further added with a proteinase-inhibitor effective to inhibit the action of decomposition enzymes and prevent the decomposition, e.g. aprotinin, dimethylcarbamoylmethyl-p-(p-guanidinobenzoyloxy)phenyl acetate mesylate, etc. together with the liposome-membrane constituting material. Each component is freeze-dried and mixed with each other before encapsulation. The liposome is preferably a multi-layered liposome having a size of about 1mu, and having 2-3 layers. The osmotic pressure of the aqueous phase in the liposome is preferably higher than that of the absorbing cell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8063081A JPS57197213A (en) | 1981-05-26 | 1981-05-26 | Orally administrable preparation of anticoagulant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8063081A JPS57197213A (en) | 1981-05-26 | 1981-05-26 | Orally administrable preparation of anticoagulant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57197213A true JPS57197213A (en) | 1982-12-03 |
Family
ID=13723670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8063081A Pending JPS57197213A (en) | 1981-05-26 | 1981-05-26 | Orally administrable preparation of anticoagulant |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57197213A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6056918A (en) * | 1983-08-03 | 1985-04-02 | ビオメデイカ・フオスカマ・インデユストリア・キミコ−フアルマチエウテイカ・エツセ・ピ・ア | Liposome containing frustose-1,6-diphosphoric acid |
| WO2021201950A1 (en) * | 2020-04-04 | 2021-10-07 | The Board Of Regents Of The University Of Texas System | Method for reducing the occurrence of thrombosis or thromboembolism |
-
1981
- 1981-05-26 JP JP8063081A patent/JPS57197213A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6056918A (en) * | 1983-08-03 | 1985-04-02 | ビオメデイカ・フオスカマ・インデユストリア・キミコ−フアルマチエウテイカ・エツセ・ピ・ア | Liposome containing frustose-1,6-diphosphoric acid |
| WO2021201950A1 (en) * | 2020-04-04 | 2021-10-07 | The Board Of Regents Of The University Of Texas System | Method for reducing the occurrence of thrombosis or thromboembolism |
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