JPS57175123A - Antitumor agent and its preparation - Google Patents

Antitumor agent and its preparation

Info

Publication number
JPS57175123A
JPS57175123A JP56058460A JP5846081A JPS57175123A JP S57175123 A JPS57175123 A JP S57175123A JP 56058460 A JP56058460 A JP 56058460A JP 5846081 A JP5846081 A JP 5846081A JP S57175123 A JPS57175123 A JP S57175123A
Authority
JP
Japan
Prior art keywords
streptococcus
lactic
formamide
liquid
centrifuged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56058460A
Other languages
Japanese (ja)
Inventor
Makoto Enomoto
Hideyo Itakura
Yoshio Ueno
Yosuke Kawasaki
Fusae Iida
Yasushi Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KIYOKUTOU SHIBOUSAN KK
Kyokuto Fatty-Acid Corp
Original Assignee
KIYOKUTOU SHIBOUSAN KK
Kyokuto Fatty-Acid Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KIYOKUTOU SHIBOUSAN KK, Kyokuto Fatty-Acid Corp filed Critical KIYOKUTOU SHIBOUSAN KK
Priority to JP56058460A priority Critical patent/JPS57175123A/en
Publication of JPS57175123A publication Critical patent/JPS57175123A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain an antitumor agent having improved remedial effect with low toxicity in a small dose, by using a composition containing a polysaccharide constituting a special structure attached to a cellular wall skeleton of a lactic streptococcus as an active constituent.
CONSTITUTION: A lactic streptococcus, e.g. Streptococcus lactic BK-045 strain (FERM-P. No. 4591), is cultivated in a culture medium at 25W37°C, preferably by the liquid spinner culture method, and then collected. The resultant microbial cell of the lactic streptococcus is crushed, centrifuged and filtered to give a sediment, which is heated with formamide and then cooled. The volume of the formamide to be added is 10 times that of the residuum. The solution of the microbial cell is treated with the formamide is then mixed with an acidic alcohol, and centrifuged togive a supernatnat liquid. The resultant supernatant liquid is treated with acetone to afford a precipitate which is an active constituent. The dosage form thereof is powder, capsule, suspension or granule, and can be administered orally, intraperitoneally or intravascularly.
COPYRIGHT: (C)1982,JPO&Japio
JP56058460A 1981-04-20 1981-04-20 Antitumor agent and its preparation Pending JPS57175123A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56058460A JPS57175123A (en) 1981-04-20 1981-04-20 Antitumor agent and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56058460A JPS57175123A (en) 1981-04-20 1981-04-20 Antitumor agent and its preparation

Publications (1)

Publication Number Publication Date
JPS57175123A true JPS57175123A (en) 1982-10-28

Family

ID=13085030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56058460A Pending JPS57175123A (en) 1981-04-20 1981-04-20 Antitumor agent and its preparation

Country Status (1)

Country Link
JP (1) JPS57175123A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331564A3 (en) * 1988-02-26 1992-01-08 Societe De Developpements Et D'innovations Des Marches Agricoles Et Alimentaires - Sodima- Union Des Cooperatives Agricoles Polysaccharide, use as a thickening agent and as an anti-tumour agent
WO1997024130A1 (en) * 1995-12-27 1997-07-10 Ngk Insulators, Ltd. CANCEROUS METASTASIS INHIBITOR COMPRISING SURFACE POLYSACCHARIDE OF STREPTOCOCCUS AGALACTIAE Ia TYPE OR Ib TYPE AS PRINCIPAL COMPONENT

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331564A3 (en) * 1988-02-26 1992-01-08 Societe De Developpements Et D'innovations Des Marches Agricoles Et Alimentaires - Sodima- Union Des Cooperatives Agricoles Polysaccharide, use as a thickening agent and as an anti-tumour agent
WO1997024130A1 (en) * 1995-12-27 1997-07-10 Ngk Insulators, Ltd. CANCEROUS METASTASIS INHIBITOR COMPRISING SURFACE POLYSACCHARIDE OF STREPTOCOCCUS AGALACTIAE Ia TYPE OR Ib TYPE AS PRINCIPAL COMPONENT
US5939404A (en) * 1995-12-27 1999-08-17 Ngk Insulators, Ltd. Cancer metastasis inhibitor containing a streptococcus agalactiae Ia type or Ib type surface polysaccharide as a main ingredient

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