JPS57159781A - Dihydrobenzofuranyl derivative, manufacture and medicinal composition containing same - Google Patents

Dihydrobenzofuranyl derivative, manufacture and medicinal composition containing same

Info

Publication number
JPS57159781A
JPS57159781A JP57038831A JP3883182A JPS57159781A JP S57159781 A JPS57159781 A JP S57159781A JP 57038831 A JP57038831 A JP 57038831A JP 3883182 A JP3883182 A JP 3883182A JP S57159781 A JPS57159781 A JP S57159781A
Authority
JP
Japan
Prior art keywords
dihydrobenzofuranyl
derivative
manufacture
composition containing
medicinal composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP57038831A
Other languages
English (en)
Inventor
Edowaado Maakuueru Rojiyaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of JPS57159781A publication Critical patent/JPS57159781A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP57038831A 1981-03-12 1982-03-11 Dihydrobenzofuranyl derivative, manufacture and medicinal composition containing same Pending JPS57159781A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8107837 1981-03-12

Publications (1)

Publication Number Publication Date
JPS57159781A true JPS57159781A (en) 1982-10-01

Family

ID=44720366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57038831A Pending JPS57159781A (en) 1981-03-12 1982-03-11 Dihydrobenzofuranyl derivative, manufacture and medicinal composition containing same

Country Status (10)

Country Link
US (1) US4428940A (ja)
EP (1) EP0060668B1 (ja)
JP (1) JPS57159781A (ja)
AU (1) AU556040B2 (ja)
CA (1) CA1183836A (ja)
DE (1) DE3266746D1 (ja)
ES (1) ES510401A0 (ja)
IE (1) IE52631B1 (ja)
NZ (1) NZ199967A (ja)
ZA (1) ZA821621B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387717B (de) * 1983-03-16 1989-03-10 Immuno Ag Verfahren zum bestimmen von unvertraeglichkeitsreaktionen verursachenden substanzen in therapeutisch und prophylaktisch anzuwendenden blutprodukten sowie verwendung des verfahrens
US4801721A (en) * 1984-08-16 1989-01-31 Ryan James W Stereospecific synthesis of carboxyalkyl peptides
AU2002348276A1 (en) 2001-11-16 2003-06-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8080579B2 (en) 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US8198311B2 (en) 2006-11-01 2012-06-12 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2089355A2 (en) 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2015027021A1 (en) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192878A (en) 1976-12-03 1980-03-11 E. R. Squibb & Sons, Inc. Derivatives of thiazolidinecarboxylic acids and related acids
IT7851510A0 (it) * 1977-10-28 1978-10-16 Sandoz Ag Ammidi di amminoacidi ciclici loro preparazione e loro applicazione quali medicamenti
US4282235A (en) 1978-05-22 1981-08-04 E. R. Squibb & Sons, Inc. Derivatives of thiazolidinecarboxylic acids and related acids
US4308392A (en) 1979-12-03 1981-12-29 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
GB2065643B (en) 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids

Also Published As

Publication number Publication date
EP0060668A1 (en) 1982-09-22
IE52631B1 (en) 1988-01-06
IE820556L (en) 1982-09-10
ES8303402A1 (es) 1983-02-01
CA1183836A (en) 1985-03-12
AU8135182A (en) 1982-09-16
US4428940A (en) 1984-01-31
ZA821621B (en) 1983-01-26
NZ199967A (en) 1985-08-30
EP0060668B1 (en) 1985-10-09
AU556040B2 (en) 1986-10-23
ES510401A0 (es) 1983-02-01
DE3266746D1 (en) 1985-11-14

Similar Documents

Publication Publication Date Title
IL65056A0 (en) Imidazodiazepines,their manufacture and pharmaceutical compositions containing them
IL66501A (en) Benzazepine-2-one derivatives,their manufacture and pharmaceutical compositions containing them
IL66099A0 (en) N-aryl-piperazinealkanamides,their preparation and pharmaceutical compositions containing them
PH22863A (en) Pyrrolobenzimidazoles and pharmaceutical composition containing them
IL64847A0 (en) Hexapyranose compounds,their manufacture and pharmaceutical compositions containing them
IL65167A (en) N-acyl-polypeptides,their production and pharmaceutical compositions containing them
IL66683A0 (en) Benzo-heterocycles,their preparation and pharmaceutical compositions containing them
NZ201520A (en) Substituted aminopyridazines and pharmaceutical compositions
JPS57159781A (en) Dihydrobenzofuranyl derivative, manufacture and medicinal composition containing same
EP0069399A3 (en) Ubidecarenone-containing liposome and pharmaceutical composition containing the same
JPS57183724A (en) Medicinal composition and manufacture
IL67284A (en) N-substituted-2-pyridylindoles,their manufacture and pharmaceutical compositions containing them
JPS57149230A (en) Medicinal composition
IL64896A0 (en) Pyrrolidine derivative,its manufacture and pharmaceutical compositions containing it
PH16694A (en) Platinum compounds and pharmaceutical composition thereof
IL65177A (en) Fluoroprostacyclins,their preparation and pharmaceutical compositions containing them
JPS57206615A (en) Medicinal composition containing guanfasin
JPS57159766A (en) Anorexic substituted trifluoromethylphenyl- tetrahydropyridines, manufacture and pharmaceutical composition
JPS5781493A (en) Ammoniomethyl compound, manufacture and medicinal composition containing same
PH16754A (en) Novel acylamino-benzazole derivatives,and pharmaceutical composition containing same
JPS56139479A (en) Quinoline derivative, manufacture and medicinal composition containing same
JPS56139482A (en) 3-chloro-quinoline derivative, manufacture and medicinal composition
JPS57156357A (en) Sulfur-aggregate composition and manufacture
IL67426A0 (en) Imidazobenzodiazepines,their manufacture and pharmaceutical compositions containing them
JPS57179183A (en) 1-substituted-4-phenyl-polyhydro-pyridines and pyrrolidines, manufacture and medicinal composition containing same