JPS57154129A - Cardiotonic drug - Google Patents
Cardiotonic drugInfo
- Publication number
- JPS57154129A JPS57154129A JP3819281A JP3819281A JPS57154129A JP S57154129 A JPS57154129 A JP S57154129A JP 3819281 A JP3819281 A JP 3819281A JP 3819281 A JP3819281 A JP 3819281A JP S57154129 A JPS57154129 A JP S57154129A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- cardiotonic drug
- halogen
- compound
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003177 cardiotonic effect Effects 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 230000001965 increasing effect Effects 0.000 abstract 2
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 2
- DNDQMUYOLGAAMQ-UHFFFAOYSA-N 5-(2-aminoacetyl)-8-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical compound N1C(=O)CCC2=C1C(O)=CC=C2C(=O)CN DNDQMUYOLGAAMQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005741 alkyl alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 230000009090 positive inotropic effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3819281A JPS57154129A (en) | 1981-03-16 | 1981-03-16 | Cardiotonic drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3819281A JPS57154129A (en) | 1981-03-16 | 1981-03-16 | Cardiotonic drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57154129A true JPS57154129A (en) | 1982-09-22 |
| JPH0153248B2 JPH0153248B2 (en, 2012) | 1989-11-13 |
Family
ID=12518493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3819281A Granted JPS57154129A (en) | 1981-03-16 | 1981-03-16 | Cardiotonic drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57154129A (en, 2012) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0240015A2 (en) | 1986-04-02 | 1987-10-07 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use |
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| US4886809A (en) * | 1986-07-31 | 1989-12-12 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof |
| US5227381A (en) * | 1988-05-02 | 1993-07-13 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative |
| US5434164A (en) * | 1986-04-02 | 1995-07-18 | Otsuka Pharmaceutical Co. Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes |
| US5591751A (en) * | 1993-02-16 | 1997-01-07 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilators |
| US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
| WO2004087142A1 (en) * | 2003-04-04 | 2004-10-14 | Novartis Ag | Quinoline-2-one-derivatives for the treatment of airways diseases |
| WO2007102008A1 (en) * | 2006-03-09 | 2007-09-13 | Sosei R & D Ltd. | The use of beta-aminoalcohols in the treatment of inflammatory disorders and pain |
| US8445516B2 (en) | 2004-01-29 | 2013-05-21 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical composition for promoting angiogenesis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52282A (en) * | 1975-06-23 | 1977-01-05 | Otsuka Pharmaceut Co Ltd | Process for preparation of carbostyril derivatives |
| JPS5283379A (en) * | 1975-12-26 | 1977-07-12 | Otsuka Pharmaceut Co Ltd | Synthesis of carbostyril derivatives |
| JPS53112883A (en) * | 1977-03-14 | 1978-10-02 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
-
1981
- 1981-03-16 JP JP3819281A patent/JPS57154129A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52282A (en) * | 1975-06-23 | 1977-01-05 | Otsuka Pharmaceut Co Ltd | Process for preparation of carbostyril derivatives |
| JPS5283379A (en) * | 1975-12-26 | 1977-07-12 | Otsuka Pharmaceut Co Ltd | Synthesis of carbostyril derivatives |
| JPS53112883A (en) * | 1977-03-14 | 1978-10-02 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0240015A2 (en) | 1986-04-02 | 1987-10-07 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use |
| US5008274A (en) * | 1986-04-02 | 1991-04-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes |
| US5434164A (en) * | 1986-04-02 | 1995-07-18 | Otsuka Pharmaceutical Co. Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes |
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| US4886809A (en) * | 1986-07-31 | 1989-12-12 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof |
| US5227381A (en) * | 1988-05-02 | 1993-07-13 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative |
| US5591751A (en) * | 1993-02-16 | 1997-01-07 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilators |
| US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
| US5760058A (en) * | 1993-04-07 | 1998-06-02 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
| WO2004087142A1 (en) * | 2003-04-04 | 2004-10-14 | Novartis Ag | Quinoline-2-one-derivatives for the treatment of airways diseases |
| US8445516B2 (en) | 2004-01-29 | 2013-05-21 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical composition for promoting angiogenesis |
| WO2007102008A1 (en) * | 2006-03-09 | 2007-09-13 | Sosei R & D Ltd. | The use of beta-aminoalcohols in the treatment of inflammatory disorders and pain |
| JP2009529519A (ja) * | 2006-03-09 | 2009-08-20 | ソーセイ アールアンドディ リミテッド | 炎症性疾患および疼痛の治療における、β−アミノアルコールの使用 |
| US8188150B2 (en) | 2006-03-09 | 2012-05-29 | Biocopea Limited | Use of beta-aminoalcohols in the treatment of inflammatory disorders and pain |
| JP2013049680A (ja) * | 2006-03-09 | 2013-03-14 | Biocopea Ltd | 炎症性疾患および疼痛の治療における、β−アミノアルコールの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0153248B2 (en, 2012) | 1989-11-13 |
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