JPS57150680A - Fluorescent polarization immunodetermination employing substituted carboxyfluorescein - Google Patents

Fluorescent polarization immunodetermination employing substituted carboxyfluorescein

Info

Publication number
JPS57150680A
JPS57150680A JP57022907A JP2290782A JPS57150680A JP S57150680 A JPS57150680 A JP S57150680A JP 57022907 A JP57022907 A JP 57022907A JP 2290782 A JP2290782 A JP 2290782A JP S57150680 A JPS57150680 A JP S57150680A
Authority
JP
Japan
Prior art keywords
immunodetermination
fluorescent polarization
employing substituted
substituted carboxyfluorescein
carboxyfluorescein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57022907A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0123061B2 (fr
Inventor
Jiefurii Wangu Chiyaoohiyuu
Denhamu Sutoroopu Sutefuan
Anesuto Jiyorii Maikeru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JPS57150680A publication Critical patent/JPS57150680A/ja
Publication of JPH0123061B2 publication Critical patent/JPH0123061B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP57022907A 1981-02-17 1982-02-17 Fluorescent polarization immunodetermination employing substituted carboxyfluorescein Granted JPS57150680A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23525981A 1981-02-17 1981-02-17

Publications (2)

Publication Number Publication Date
JPS57150680A true JPS57150680A (en) 1982-09-17
JPH0123061B2 JPH0123061B2 (fr) 1989-04-28

Family

ID=22884765

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57022907A Granted JPS57150680A (en) 1981-02-17 1982-02-17 Fluorescent polarization immunodetermination employing substituted carboxyfluorescein

Country Status (6)

Country Link
JP (1) JPS57150680A (fr)
AU (1) AU555213B2 (fr)
BE (1) BE892158A (fr)
FR (1) FR2500165B1 (fr)
GB (1) GB2111476B (fr)
IT (1) IT1157305B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59101481A (ja) * 1982-11-08 1984-06-12 アボツト・ラボラトリ−ズ 置換カルボキシフルオレセイン
JPS59101480A (ja) * 1982-11-08 1984-06-12 アボツト・ラボラトリ−ズ 蛍光偏光免疫試験用試薬及び配位子測定法
JPS59104554A (ja) * 1982-11-08 1984-06-16 アボツト・ラボラトリ−ズ 螢光偏光技術を用いる不飽和チロキシン結合性蛋白位置の測定法
JPS6097272A (ja) * 1983-10-07 1985-05-31 シンテツクス（ユー・エス・エイ）インコーポレーテツド 免疫螢光法
JPS6293259A (ja) * 1985-10-15 1987-04-28 アボツト　ラボラトリ−ズ 三環式抗うつ薬用の化合物及び定量法
JPS62249049A (ja) * 1986-02-07 1987-10-30 アプライド　バイオシステムズ　インコ−ポレイテツド 分離されたオリゴヌクレオチド類を電気泳動的に検出する方法
JPH01272967A (ja) * 1988-04-26 1989-10-31 Matsushita Electric Ind Co Ltd 免疫的検出法
JPH04500731A (ja) * 1989-07-11 1992-02-06 ベーリング　ダイアグノスティクス　インコーポレイテッド 診断用アッセイ系

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510251A (en) * 1982-11-08 1985-04-09 Abbott Laboratories Fluorescent polarization assay for ligands using aminomethylfluorescein derivatives as tracers
US4591569A (en) * 1984-04-11 1986-05-27 Becton Dickinson & Company Homogeneous fluorescent triiodothyronine uptake test
ZA857256B (en) * 1984-10-25 1986-05-28 Abbott Lab Fluorescence polarization assay,reagents,and method of making reagents,for determination of digitoxin
EP0184120A3 (fr) * 1984-11-29 1987-12-09 Abbott Laboratories Traceurs pour l'essai de disopyramide et immunogènes pour la production d'anticorps
EP0199042A1 (fr) * 1985-03-26 1986-10-29 Abbott Laboratories Dosage, traceurs, immunogènes et anticorps du procainamide
EP0199963B1 (fr) * 1985-04-01 1991-10-23 Abbott Laboratories Dosage, traceurs, immunogènes et anticorps de l'éthosuximide
US4698315A (en) * 1985-04-22 1987-10-06 Hoffmann-La Roche Inc. Method and kit for determining total digoxin levels involving agent to dissociate digoxin-protein complex
EP0210410B1 (fr) * 1985-07-22 1992-05-20 Abbott Laboratories Immuno-essai par polarisation de fluorescence et réactifs pour la mesure de la protéine C-réactive
US5336622A (en) * 1986-04-25 1994-08-09 Abbott Laboratories Tracers for use in flecainide fluorescence polarization immunoassay
US5124457A (en) * 1986-05-21 1992-06-23 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies
US5221629A (en) * 1986-05-21 1993-06-22 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies
US5155212A (en) * 1986-05-21 1992-10-13 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
US4939264A (en) * 1986-07-14 1990-07-03 Abbott Laboratories Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
US4784961A (en) * 1987-03-23 1988-11-15 Abbott Laboratories Fluorescence polarization method for monitoring fetal lung maturity
US5223627A (en) * 1986-07-15 1993-06-29 Abbott Laboratories Fluorescence polarization method for monitoring fetal lung maturity
US4868132A (en) * 1987-02-03 1989-09-19 Abbott Laboratories Fluorescence polarization immunoassay for amphetamine/methamphetamine
US5100807A (en) * 1987-10-19 1992-03-31 Abbott Laboratories Phenylacetylglutamine (pag) analytical test
US5051361A (en) * 1988-10-19 1991-09-24 Sigma Chemical Company AZT immunoassays, derivatives, conjugates and antibodies
US5262333A (en) * 1988-10-28 1993-11-16 Abbott Laboratories Method and reagents for detecting amphetamine and/or D-methamphetamine in biological samples
US5073629A (en) * 1989-01-23 1991-12-17 Abbott Laboratories Methadone fluorescence polarization immunoassay
US5248791A (en) * 1989-04-10 1993-09-28 Abbott Laboratories Reagents, methods and kits for an amphetamine-class fluorescence polarization immunoassay
US5101015A (en) * 1989-04-10 1992-03-31 Abbott Laboratories Reagents for an amphetamine-class fluorescence polarization immunoassay
US5096838A (en) * 1989-11-27 1992-03-17 Abbott Laboratories Barbiturate assay compositions and methods
US5099020A (en) * 1989-11-27 1992-03-24 Abbott Laboratories Barbiturate assay compositions and methods
ES2106040T3 (es) * 1990-05-16 1997-11-01 Abbott Lab Ensayo para barbituratos, trazadores, inmunogenos, anticuerpos y kit.
GB9024176D0 (en) * 1990-11-07 1990-12-19 Medical Res Council Photolabile compounds,their synthesis and use as fluorophores
US5407835A (en) * 1991-07-31 1995-04-18 Abbott Laboratories Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids
US5952187A (en) * 1995-12-01 1999-09-14 Oxis International, Inc. Topiramate immunoassay
IT1298693B1 (it) * 1996-04-24 2000-01-12 Hoffmann La Roche Derivati della fluoresceina 4'-metil sostituiti

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55119061A (en) * 1979-03-05 1980-09-12 Syva Co Method of analyzing competitive protein linkage while preventing nonnspecific interference

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US4222744A (en) * 1978-09-27 1980-09-16 Becton Dickinson & Company Assay for ligands

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55119061A (en) * 1979-03-05 1980-09-12 Syva Co Method of analyzing competitive protein linkage while preventing nonnspecific interference

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59101481A (ja) * 1982-11-08 1984-06-12 アボツト・ラボラトリ−ズ 置換カルボキシフルオレセイン
JPS59101480A (ja) * 1982-11-08 1984-06-12 アボツト・ラボラトリ−ズ 蛍光偏光免疫試験用試薬及び配位子測定法
JPS59104554A (ja) * 1982-11-08 1984-06-16 アボツト・ラボラトリ−ズ 螢光偏光技術を用いる不飽和チロキシン結合性蛋白位置の測定法
JPH0475465B2 (fr) * 1982-11-08 1992-11-30
JPS6097272A (ja) * 1983-10-07 1985-05-31 シンテツクス（ユー・エス・エイ）インコーポレーテツド 免疫螢光法
JPS6293259A (ja) * 1985-10-15 1987-04-28 アボツト　ラボラトリ−ズ 三環式抗うつ薬用の化合物及び定量法
JPS62249049A (ja) * 1986-02-07 1987-10-30 アプライド　バイオシステムズ　インコ−ポレイテツド 分離されたオリゴヌクレオチド類を電気泳動的に検出する方法
JPH01272967A (ja) * 1988-04-26 1989-10-31 Matsushita Electric Ind Co Ltd 免疫的検出法
JPH04500731A (ja) * 1989-07-11 1992-02-06 ベーリング　ダイアグノスティクス　インコーポレイテッド 診断用アッセイ系

Also Published As

Publication number Publication date
FR2500165B1 (fr) 1985-06-14
AU8032882A (en) 1982-08-26
FR2500165A1 (fr) 1982-08-20
IT8219675A0 (it) 1982-02-16
GB2111476B (en) 1985-04-03
GB2111476A (en) 1983-07-06
BE892158A (fr) 1982-08-16
IT1157305B (it) 1987-02-11
AU555213B2 (en) 1986-09-18
JPH0123061B2 (fr) 1989-04-28

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