JPS57150664A - Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol - Google Patents

Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol

Info

Publication number
JPS57150664A
JPS57150664A JP3703881A JP3703881A JPS57150664A JP S57150664 A JPS57150664 A JP S57150664A JP 3703881 A JP3703881 A JP 3703881A JP 3703881 A JP3703881 A JP 3703881A JP S57150664 A JPS57150664 A JP S57150664A
Authority
JP
Japan
Prior art keywords
benzylpiperidino
benzyloxyphenyl
propanol
reducing
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3703881A
Other languages
Japanese (ja)
Inventor
Hiromitsu Saito
Kazuo Satoie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOHO IYAKU KENKYUSHO KK
Original Assignee
TOHO IYAKU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOHO IYAKU KENKYUSHO KK filed Critical TOHO IYAKU KENKYUSHO KK
Priority to JP3703881A priority Critical patent/JPS57150664A/en
Publication of JPS57150664A publication Critical patent/JPS57150664A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the erythro-type titled compound useful as an intermediate of a remedy for the after-effect of cerebral infarction, etc., in high selectivity, by reducing 2-(4-benzylpiperidino)-1-(4-benzyloxyphenyl)-propan-1-one with diborane.
CONSTITUTION: 2-(4-Benzylpiperidino)-1-(4-benzyloxyphenyl)-1-propanol of formulaIis prepared by reducing 2-(4-benzylpiperidino)-1-(4-benzyloxyphenyl)-propan-1- one with diborane as the reducing agent. The erythro-type compound of formulaIcan be obtained in preference to the threo-type compound, and its content in the product reaches as high as 95%.
USE: Intermediate of compound of formula III which is a remedy for the aftereffects of cerebral hemorrhage such as dizziness, headache, etc. and mental symptoms such as depression, uneasiness, excitation, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP3703881A 1981-03-14 1981-03-14 Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol Pending JPS57150664A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3703881A JPS57150664A (en) 1981-03-14 1981-03-14 Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3703881A JPS57150664A (en) 1981-03-14 1981-03-14 Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol

Publications (1)

Publication Number Publication Date
JPS57150664A true JPS57150664A (en) 1982-09-17

Family

ID=12486439

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3703881A Pending JPS57150664A (en) 1981-03-14 1981-03-14 Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol

Country Status (1)

Country Link
JP (1) JPS57150664A (en)

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