JPS57150664A - Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol - Google Patents
Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanolInfo
- Publication number
- JPS57150664A JPS57150664A JP3703881A JP3703881A JPS57150664A JP S57150664 A JPS57150664 A JP S57150664A JP 3703881 A JP3703881 A JP 3703881A JP 3703881 A JP3703881 A JP 3703881A JP S57150664 A JPS57150664 A JP S57150664A
- Authority
- JP
- Japan
- Prior art keywords
- benzylpiperidino
- benzyloxyphenyl
- propanol
- reducing
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the erythro-type titled compound useful as an intermediate of a remedy for the after-effect of cerebral infarction, etc., in high selectivity, by reducing 2-(4-benzylpiperidino)-1-(4-benzyloxyphenyl)-propan-1-one with diborane.
CONSTITUTION: 2-(4-Benzylpiperidino)-1-(4-benzyloxyphenyl)-1-propanol of formulaIis prepared by reducing 2-(4-benzylpiperidino)-1-(4-benzyloxyphenyl)-propan-1- one with diborane as the reducing agent. The erythro-type compound of formulaIcan be obtained in preference to the threo-type compound, and its content in the product reaches as high as 95%.
USE: Intermediate of compound of formula III which is a remedy for the aftereffects of cerebral hemorrhage such as dizziness, headache, etc. and mental symptoms such as depression, uneasiness, excitation, etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3703881A JPS57150664A (en) | 1981-03-14 | 1981-03-14 | Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3703881A JPS57150664A (en) | 1981-03-14 | 1981-03-14 | Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57150664A true JPS57150664A (en) | 1982-09-17 |
Family
ID=12486439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3703881A Pending JPS57150664A (en) | 1981-03-14 | 1981-03-14 | Preparation of 2-(4-benzylpiperidino)-1-(4- benzyloxyphenyl)- 1-propanol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57150664A (en) |
-
1981
- 1981-03-14 JP JP3703881A patent/JPS57150664A/en active Pending
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