JPS57143302A - Clucide corticoid-cyclodextrin clathrate compound and anti-inflammatory external agent containing the same as active constituent - Google Patents
Clucide corticoid-cyclodextrin clathrate compound and anti-inflammatory external agent containing the same as active constituentInfo
- Publication number
- JPS57143302A JPS57143302A JP2935181A JP2935181A JPS57143302A JP S57143302 A JPS57143302 A JP S57143302A JP 2935181 A JP2935181 A JP 2935181A JP 2935181 A JP2935181 A JP 2935181A JP S57143302 A JPS57143302 A JP S57143302A
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- corticoid
- water
- compound
- external agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: The titled water-soluble compound, useful as an anti-inflammatory external agent, etc., having improved stability to light, hydrogen ion concentration, etc., and prepared by including a glucide corticoid in cyclodextrin.
CONSTITUTION: (A) A glucide corticoid, e.g. betamethasone, and (B) cyclodextrin, e.g.β-cyclodextrin, are dissolved in water under heating, and reacted with stirring at room temperature. The formed precipitate is then filtered, and dried under reduced pressure to give the aimed compound. The resultant compound is dissolved in a mixed solution of water with ethanol (1:1 by volume), and the absorbance is measured in the ultraviolet region (241 nm) to determine the inclusion ratio. The ratio is 2 moles β-cyclodextrin and 3 moles γ-cyclodextrin based on one mole component (A).
EFFECT: The clathrate compound has a higher solubility than the component (A) by the measurement of the dissolving behavior (in water, 25°C) by the rotating disc method.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2935181A JPS57143302A (en) | 1981-03-03 | 1981-03-03 | Clucide corticoid-cyclodextrin clathrate compound and anti-inflammatory external agent containing the same as active constituent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2935181A JPS57143302A (en) | 1981-03-03 | 1981-03-03 | Clucide corticoid-cyclodextrin clathrate compound and anti-inflammatory external agent containing the same as active constituent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57143302A true JPS57143302A (en) | 1982-09-04 |
JPS649996B2 JPS649996B2 (en) | 1989-02-21 |
Family
ID=12273789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2935181A Granted JPS57143302A (en) | 1981-03-03 | 1981-03-03 | Clucide corticoid-cyclodextrin clathrate compound and anti-inflammatory external agent containing the same as active constituent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57143302A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6034156A (en) * | 1983-08-08 | 1985-02-21 | Hayashibara Biochem Lab Inc | Eicosapentaenoic acid clathrate compound and food and drink containing the same |
US5407667A (en) * | 1990-02-13 | 1995-04-18 | Kyowa Hakko Kogyo Co., Ltd. | Composition containing inclusion complex of glutathione and a or β-cyclodextrine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522616A (en) * | 1978-08-04 | 1980-02-18 | Tokyo Tanabe Co Ltd | Bile acid inclusion compound and injection containing the same |
-
1981
- 1981-03-03 JP JP2935181A patent/JPS57143302A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522616A (en) * | 1978-08-04 | 1980-02-18 | Tokyo Tanabe Co Ltd | Bile acid inclusion compound and injection containing the same |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6034156A (en) * | 1983-08-08 | 1985-02-21 | Hayashibara Biochem Lab Inc | Eicosapentaenoic acid clathrate compound and food and drink containing the same |
US5407667A (en) * | 1990-02-13 | 1995-04-18 | Kyowa Hakko Kogyo Co., Ltd. | Composition containing inclusion complex of glutathione and a or β-cyclodextrine |
Also Published As
Publication number | Publication date |
---|---|
JPS649996B2 (en) | 1989-02-21 |
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