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Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Chugai Pharmaceutical Co LtdfiledCriticalChugai Pharmaceutical Co Ltd
Priority to JP8592480ApriorityCriticalpatent/JPS5711996A/en
Publication of JPS5711996ApublicationCriticalpatent/JPS5711996A/en
NEW MATERIAL:A coenzyme A compound shown by the formula I [R' is a group shown by the formula II or formula III (I* shows that iodine may be marked by a radioisotope) linked to the 2-, 6-, or 8-position of purine ring; R1 is amino or as shown for R'; R2 and R3 and H, phosphoric acid group, or form a group shown by the formula IV] or its salt.
EXAMPLE: A lithium salt of 8-(4-hydroxy-3-iodophenetilamino)-3'-dephospho coenzyme A.
USE: A diagnosticum for cancer. Diagnosis is carried out by determining the concentration of coenzyme A in humors.
PROCESS: A compound shown by the formula V or its salt is conventionally led to a reactive derivative, which is reacted with 4'-phosphopantetheine or its salt, to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8592480A1980-06-261980-06-26Novel coenzyme a compound and its preparation
PendingJPS5711996A
(en)