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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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Application filed by Sumitomo Chemical Co LtdfiledCriticalSumitomo Chemical Co Ltd
Priority to JP221881ApriorityCriticalpatent/JPS57116009A/en
Publication of JPS57116009ApublicationCriticalpatent/JPS57116009A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PURPOSE: To prepare a composition for injection containing specific penicillanic acid sodium salt derivative useful as an antibacterial agent, having improved rate of dissolution of the above active component without losing the stability and safety as an injection, by adding L-arginine to the active component.
CONSTITUTION: The objective injection composition contains (A) 1mol of (6-[D- (α)-( 4-hydroxy-1, 5-naphthyridine-3-carboxyamido )phenylacetamido]penicillanic acid sodium salt (PC) of formula and (B) pref. 0.1W1mol, esp. 0.25W0.5mol of L- arginine. The composition is pref. freeze-dried. Since the composition has the above effects, it can be used with remarkably improved convenience, and can be administered by intramuscular injection at a rate of as high as 500mg (titer)/3ml, thereby extending the applicable range of PC. The reduction of the pain in the intramuscular injection is also expected.
COPYRIGHT: (C)1982,JPO&Japio
JP221881A1981-01-091981-01-09Composition for injection
PendingJPS57116009A
(en)
N-METHYL-D-GLUCAMINE SALT OF 3,4-DIHYDRO-5-METHYL-6- (2-METHYL-PROPYL) -4-OXOTIENO (2,3-D) PYRIMIDIN-2-CARBOXYLIC ACID AND PHARMACEUTICAL COMPOSITION CONTAINING THIS SALT