JPS57106655A - Cyclic compound and its preparation - Google Patents

Cyclic compound and its preparation

Info

Publication number
JPS57106655A
JPS57106655A JP18335080A JP18335080A JPS57106655A JP S57106655 A JPS57106655 A JP S57106655A JP 18335080 A JP18335080 A JP 18335080A JP 18335080 A JP18335080 A JP 18335080A JP S57106655 A JPS57106655 A JP S57106655A
Authority
JP
Japan
Prior art keywords
lower alkyl
compound shown
acyl
cyclic compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18335080A
Other languages
Japanese (ja)
Inventor
Yoshikazu Oka
Kohei Nishikawa
Akio Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP18335080A priority Critical patent/JPS57106655A/en
Priority to EP19810300901 priority patent/EP0035868A1/en
Priority to CA000372474A priority patent/CA1168233A/en
Publication of JPS57106655A publication Critical patent/JPS57106655A/en
Pending legal-status Critical Current

Links

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A cyclic compound shown by the formulaI[R1 and R2 are H, halogen, lower alkyl, etc.; R3 and R4 are H or lower alkyl; R5 is H, lower alkyl, -CH2SR7(R7 is H or acyl); R6 is H, acyl, or R6 and R7 may form one single bond; X is methylene, O, N-R8 (R8 is H, acyl, lower alkyl); n is 2, 3 or 4].
EXAMPLE: N-(3-Acetylthio-2-methylpropionyl)-N-(6-methoxy-1-indayl)glycine.
USE: A preventive and remedy for hypertension. An anodyne. An enhancer for analgesic action.
PROCESS: A compound shown by the formula II is reacted with a compound shown by the formula III or its reactive derivative at its carboxyl group(e.g., acid halide, etc.) in a solvent, e.g., pyridine, etc. at -20W150C, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP18335080A 1980-03-07 1980-12-23 Cyclic compound and its preparation Pending JPS57106655A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP18335080A JPS57106655A (en) 1980-12-23 1980-12-23 Cyclic compound and its preparation
EP19810300901 EP0035868A1 (en) 1980-03-07 1981-03-04 Bicyclic compounds, their production and use
CA000372474A CA1168233A (en) 1980-03-07 1981-03-06 Thioalkanoyl amino acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18335080A JPS57106655A (en) 1980-12-23 1980-12-23 Cyclic compound and its preparation

Publications (1)

Publication Number Publication Date
JPS57106655A true JPS57106655A (en) 1982-07-02

Family

ID=16134194

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18335080A Pending JPS57106655A (en) 1980-03-07 1980-12-23 Cyclic compound and its preparation

Country Status (1)

Country Link
JP (1) JPS57106655A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016111310A1 (en) * 2015-01-06 2016-07-14 国立研究開発法人理化学研究所 Novel angiotensin converting enzyme inhibitor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016111310A1 (en) * 2015-01-06 2016-07-14 国立研究開発法人理化学研究所 Novel angiotensin converting enzyme inhibitor

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