JPS5695149A - Optical resolution of d -2- 6-methoxy-2-naphthyl -propionic acid - Google Patents
Optical resolution of d -2- 6-methoxy-2-naphthyl -propionic acidInfo
- Publication number
- JPS5695149A JPS5695149A JP17155579A JP17155579A JPS5695149A JP S5695149 A JPS5695149 A JP S5695149A JP 17155579 A JP17155579 A JP 17155579A JP 17155579 A JP17155579 A JP 17155579A JP S5695149 A JPS5695149 A JP S5695149A
- Authority
- JP
- Japan
- Prior art keywords
- naphthyl
- methoxy
- propionic acid
- optically active
- optical resolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound econimically, in an industrial scale, by reacting dl-2-(6-methoxy-2-naphthyl)-propionic acid, etc. with an optically active β-aminoethanol compound, separating the optical isomer by chromatography, and hydrolyzing the product.
CONSTITUTION: dl-2-(6-Methoxy-2-naphthyl)-propionic acid or its reactive derivative (e.g. acid chloride) is reacted with an optically active β-aminoethanol derivative of formula (R1 is H or lower alkyl; R2 is lower alkyl, lower alkoxycarbonyl, etc.; provided that R1 is not R2), to obtain a mixture of optical isomers of the corresponding amide. The mixture is subjected to chromatographic treatment to separate into each optical isomer, and the desired optically active amide is hydrolyzed to obtain d- or l-2-(6-methoxy-2-naphthyl)-propionic acid.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17155579A JPS5822139B2 (en) | 1979-12-28 | 1979-12-28 | Optical resolution method of dl-2-(6-methoxy-2-naphthyl)-propionic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17155579A JPS5822139B2 (en) | 1979-12-28 | 1979-12-28 | Optical resolution method of dl-2-(6-methoxy-2-naphthyl)-propionic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5695149A true JPS5695149A (en) | 1981-08-01 |
JPS5822139B2 JPS5822139B2 (en) | 1983-05-06 |
Family
ID=15925294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17155579A Expired JPS5822139B2 (en) | 1979-12-28 | 1979-12-28 | Optical resolution method of dl-2-(6-methoxy-2-naphthyl)-propionic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5822139B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60132930A (en) * | 1983-11-23 | 1985-07-16 | アルファ・ケミカルズ・イタリアーナ・エッセ・エルレ・エルレ | Optical resolution of racemic mixture of a-naphthylpropionicacid |
JPS61129148A (en) * | 1984-11-22 | 1986-06-17 | アルファ・ワッセルマン・エッセ・ピ・ア | Optical resolution of racemic mixture of alpha-naphthylpropionic acid |
US5200555A (en) * | 1990-07-27 | 1993-04-06 | Westpur Investment Limited | Process for the preparation of S(+)-6-methoxy-α-methyl-2-naphthalene-acetic acid |
EP0728736A1 (en) * | 1995-02-21 | 1996-08-28 | Degussa Aktiengesellschaft | Process for the preparation of optically active tert-leucinol and use thereof |
WO2001094334A1 (en) * | 2000-06-02 | 2001-12-13 | Eli Lilly & Company | Methods for resolving chiral (2s) and (2r) chromanes |
-
1979
- 1979-12-28 JP JP17155579A patent/JPS5822139B2/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60132930A (en) * | 1983-11-23 | 1985-07-16 | アルファ・ケミカルズ・イタリアーナ・エッセ・エルレ・エルレ | Optical resolution of racemic mixture of a-naphthylpropionicacid |
JPS61129148A (en) * | 1984-11-22 | 1986-06-17 | アルファ・ワッセルマン・エッセ・ピ・ア | Optical resolution of racemic mixture of alpha-naphthylpropionic acid |
US5200555A (en) * | 1990-07-27 | 1993-04-06 | Westpur Investment Limited | Process for the preparation of S(+)-6-methoxy-α-methyl-2-naphthalene-acetic acid |
EP0728736A1 (en) * | 1995-02-21 | 1996-08-28 | Degussa Aktiengesellschaft | Process for the preparation of optically active tert-leucinol and use thereof |
WO2001094334A1 (en) * | 2000-06-02 | 2001-12-13 | Eli Lilly & Company | Methods for resolving chiral (2s) and (2r) chromanes |
Also Published As
Publication number | Publication date |
---|---|
JPS5822139B2 (en) | 1983-05-06 |
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