JPS5695149A - Optical resolution of d -2- 6-methoxy-2-naphthyl -propionic acid - Google Patents

Optical resolution of d -2- 6-methoxy-2-naphthyl -propionic acid

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Publication number
JPS5695149A
JPS5695149A JP17155579A JP17155579A JPS5695149A JP S5695149 A JPS5695149 A JP S5695149A JP 17155579 A JP17155579 A JP 17155579A JP 17155579 A JP17155579 A JP 17155579A JP S5695149 A JPS5695149 A JP S5695149A
Authority
JP
Japan
Prior art keywords
naphthyl
methoxy
propionic acid
optically active
optical resolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17155579A
Other languages
Japanese (ja)
Other versions
JPS5822139B2 (en
Inventor
Katsura Kogure
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Priority to JP17155579A priority Critical patent/JPS5822139B2/en
Publication of JPS5695149A publication Critical patent/JPS5695149A/en
Publication of JPS5822139B2 publication Critical patent/JPS5822139B2/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the titled compound econimically, in an industrial scale, by reacting dl-2-(6-methoxy-2-naphthyl)-propionic acid, etc. with an optically active β-aminoethanol compound, separating the optical isomer by chromatography, and hydrolyzing the product.
CONSTITUTION: dl-2-(6-Methoxy-2-naphthyl)-propionic acid or its reactive derivative (e.g. acid chloride) is reacted with an optically active β-aminoethanol derivative of formula (R1 is H or lower alkyl; R2 is lower alkyl, lower alkoxycarbonyl, etc.; provided that R1 is not R2), to obtain a mixture of optical isomers of the corresponding amide. The mixture is subjected to chromatographic treatment to separate into each optical isomer, and the desired optically active amide is hydrolyzed to obtain d- or l-2-(6-methoxy-2-naphthyl)-propionic acid.
COPYRIGHT: (C)1981,JPO&Japio
JP17155579A 1979-12-28 1979-12-28 Optical resolution method of dl-2-(6-methoxy-2-naphthyl)-propionic acid Expired JPS5822139B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17155579A JPS5822139B2 (en) 1979-12-28 1979-12-28 Optical resolution method of dl-2-(6-methoxy-2-naphthyl)-propionic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17155579A JPS5822139B2 (en) 1979-12-28 1979-12-28 Optical resolution method of dl-2-(6-methoxy-2-naphthyl)-propionic acid

Publications (2)

Publication Number Publication Date
JPS5695149A true JPS5695149A (en) 1981-08-01
JPS5822139B2 JPS5822139B2 (en) 1983-05-06

Family

ID=15925294

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17155579A Expired JPS5822139B2 (en) 1979-12-28 1979-12-28 Optical resolution method of dl-2-(6-methoxy-2-naphthyl)-propionic acid

Country Status (1)

Country Link
JP (1) JPS5822139B2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60132930A (en) * 1983-11-23 1985-07-16 アルファ・ケミカルズ・イタリアーナ・エッセ・エルレ・エルレ Optical resolution of racemic mixture of a-naphthylpropionicacid
JPS61129148A (en) * 1984-11-22 1986-06-17 アルファ・ワッセルマン・エッセ・ピ・ア Optical resolution of racemic mixture of alpha-naphthylpropionic acid
US5200555A (en) * 1990-07-27 1993-04-06 Westpur Investment Limited Process for the preparation of S(+)-6-methoxy-α-methyl-2-naphthalene-acetic acid
EP0728736A1 (en) * 1995-02-21 1996-08-28 Degussa Aktiengesellschaft Process for the preparation of optically active tert-leucinol and use thereof
WO2001094334A1 (en) * 2000-06-02 2001-12-13 Eli Lilly & Company Methods for resolving chiral (2s) and (2r) chromanes

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60132930A (en) * 1983-11-23 1985-07-16 アルファ・ケミカルズ・イタリアーナ・エッセ・エルレ・エルレ Optical resolution of racemic mixture of a-naphthylpropionicacid
JPS61129148A (en) * 1984-11-22 1986-06-17 アルファ・ワッセルマン・エッセ・ピ・ア Optical resolution of racemic mixture of alpha-naphthylpropionic acid
US5200555A (en) * 1990-07-27 1993-04-06 Westpur Investment Limited Process for the preparation of S(+)-6-methoxy-α-methyl-2-naphthalene-acetic acid
EP0728736A1 (en) * 1995-02-21 1996-08-28 Degussa Aktiengesellschaft Process for the preparation of optically active tert-leucinol and use thereof
WO2001094334A1 (en) * 2000-06-02 2001-12-13 Eli Lilly & Company Methods for resolving chiral (2s) and (2r) chromanes

Also Published As

Publication number Publication date
JPS5822139B2 (en) 1983-05-06

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