JPS5692273A - 1-phenylisoquinoline derivative - Google Patents

1-phenylisoquinoline derivative

Info

Publication number
JPS5692273A
JPS5692273A JP16823679A JP16823679A JPS5692273A JP S5692273 A JPS5692273 A JP S5692273A JP 16823679 A JP16823679 A JP 16823679A JP 16823679 A JP16823679 A JP 16823679A JP S5692273 A JPS5692273 A JP S5692273A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
phenylisoquinoline
give
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16823679A
Other languages
Japanese (ja)
Inventor
Yasushi Suzuki
Kunio Tsukamoto
Nobuyoshi Minami
Yukio Hasegawa
Michitaka Sato
Norio Yamamoto
Katsuhiko Miyasaka
Takashi Kenjo
Satoshi Funakoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Priority to JP16823679A priority Critical patent/JPS5692273A/en
Publication of JPS5692273A publication Critical patent/JPS5692273A/en
Pending legal-status Critical Current

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  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 1-phenylisoquinoline derivative expressed by formula I (R1 is H or lower alkyl; R2 is F, Br, methyl, trifluoromethyl, methylamino or dimethylamino; Y is carboxyl or cyano) or a salt thereof.
EXAMPLE: 1-(4-Fluorophenyl)isoquinoline-5-acetic acid.
USE: An analgesic agent and an anti-inflammatory agent scarcely causing damage to digestive organs.
PROCESS: An ester of a 2-cyanomethylbenzoic acid expressed by formula II (R2 is lower alkyl) as a raw material is reduced to give a compound of formula VI-A, which is amidated with an acyl halide of formula IV (X1 is halogen) and the halogenated, nitrated, cyclized through, dehydration, dehydrogenated and alkylated to give the aimed lower alkyl derivative of a 1-phenylisoquinoline expressed by formula I-2-b (R11 is lower alkyl), and further hydrolyzed to give the aimed 1-phenylisoquinoline derivative of formula I-1-b.
COPYRIGHT: (C)1981,JPO&Japio
JP16823679A 1979-12-26 1979-12-26 1-phenylisoquinoline derivative Pending JPS5692273A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16823679A JPS5692273A (en) 1979-12-26 1979-12-26 1-phenylisoquinoline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16823679A JPS5692273A (en) 1979-12-26 1979-12-26 1-phenylisoquinoline derivative

Publications (1)

Publication Number Publication Date
JPS5692273A true JPS5692273A (en) 1981-07-25

Family

ID=15864288

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16823679A Pending JPS5692273A (en) 1979-12-26 1979-12-26 1-phenylisoquinoline derivative

Country Status (1)

Country Link
JP (1) JPS5692273A (en)

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