JPS5687599A - E 55 22halogenovinyl arabinofuranosyluracil and its preparation - Google Patents

E 55 22halogenovinyl arabinofuranosyluracil and its preparation

Info

Publication number
JPS5687599A
JPS5687599A JP16402579A JP16402579A JPS5687599A JP S5687599 A JPS5687599 A JP S5687599A JP 16402579 A JP16402579 A JP 16402579A JP 16402579 A JP16402579 A JP 16402579A JP S5687599 A JPS5687599 A JP S5687599A
Authority
JP
Japan
Prior art keywords
formula
halogen
compound
equivalent
arabinofuranosyluracil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16402579A
Other languages
English (en)
Other versions
JPS5748160B2 (ja
Inventor
Haruhiko Machida
Shinji Sakata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP16402579A priority Critical patent/JPS5687599A/ja
Priority to US06/215,928 priority patent/US4386076A/en
Priority to EP80107949A priority patent/EP0031128B1/en
Priority to DE8080107949T priority patent/DE3064165D1/de
Priority to CA000367108A priority patent/CA1150247A/en
Priority to ES498020A priority patent/ES8205234A1/es
Publication of JPS5687599A publication Critical patent/JPS5687599A/ja
Publication of JPS5748160B2 publication Critical patent/JPS5748160B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP16402579A 1979-12-19 1979-12-19 E 55 22halogenovinyl arabinofuranosyluracil and its preparation Granted JPS5687599A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP16402579A JPS5687599A (en) 1979-12-19 1979-12-19 E 55 22halogenovinyl arabinofuranosyluracil and its preparation
US06/215,928 US4386076A (en) 1979-12-19 1980-12-12 (E)-5-(2-Halogenovinyl)-arabinofuranosyluracil, process for preparation thereof, and uses thereof
EP80107949A EP0031128B1 (en) 1979-12-19 1980-12-16 (e)-5-(2-halogenovinyl)-arabinofuranosyluracil, process for preparation thereof, and uses thereof
DE8080107949T DE3064165D1 (en) 1979-12-19 1980-12-16 (e)-5-(2-halogenovinyl)-arabinofuranosyluracil, process for preparation thereof, and uses thereof
CA000367108A CA1150247A (en) 1979-12-19 1980-12-18 (e)-5-(2-halogenovinyl)-arabinofuranosyluracil, process for preparation thereof, and uses thereof
ES498020A ES8205234A1 (es) 1979-12-19 1980-12-19 Un procedimiento para al preparacion de un ce)-5-(halogenovinil)-arabino-furano-siluracilo.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16402579A JPS5687599A (en) 1979-12-19 1979-12-19 E 55 22halogenovinyl arabinofuranosyluracil and its preparation

Publications (2)

Publication Number Publication Date
JPS5687599A true JPS5687599A (en) 1981-07-16
JPS5748160B2 JPS5748160B2 (ja) 1982-10-14

Family

ID=15785357

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16402579A Granted JPS5687599A (en) 1979-12-19 1979-12-19 E 55 22halogenovinyl arabinofuranosyluracil and its preparation

Country Status (6)

Country Link
US (1) US4386076A (ja)
EP (1) EP0031128B1 (ja)
JP (1) JPS5687599A (ja)
CA (1) CA1150247A (ja)
DE (1) DE3064165D1 (ja)
ES (1) ES8205234A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019638A1 (fr) * 1991-04-24 1992-11-12 Yamasa Shoyu Kabushiki Kaisha DERIVE DE 1-β-D-ARABINOFURANOSYL-(E)-5-(2-HALOGENOVINYL)-URACILE
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
JP2007210963A (ja) * 2006-02-10 2007-08-23 Arigen Inc ピリミジンヌクレオシド誘導体及びその塩
WO2008099492A1 (ja) * 2007-02-15 2008-08-21 Arigen Pharmaceuticals, Inc. ピリミジンヌクレオシド誘導体及びその塩
US7618950B2 (en) 2004-07-07 2009-11-17 Arigen Pharmaceuticals, Inc. Method for treatment and prevention of herpes zoster by topical application

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
HU192472B (en) * 1984-10-12 1987-06-29 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uracyl derivatives
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
WO1990001324A1 (en) * 1988-08-10 1990-02-22 Stephen Leslie Sacks PRODUCTION OF RADIOIODINATED 1-β-D-ARABINOFURANOSYL)-5(E)-(2-IODOVINYL)URACIL, AND USES THEREOF, AND RELATED ANALOGUES INCORPORATING ALTERNATIVE HALOGEN RADIONUCLIDES, THE GENERAL RADIOHALOGENATION PRECURSORS, 1-(2,3,5-TRI-O-ACETYL-β-D-ARABINOFURANOSYL)-5(Z and E)-(2-TRIMETHYLSILYLVINYL)URACIL, PROCESSES FOR RADIOHA
GB8912972D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides
US5352584A (en) * 1990-01-22 1994-10-04 E. R. Squibb & Sons, Inc. Monoclonal antibodies which bind (E)-5- (2-bromovinyl)-arabinofuranosyluracil and diagnostic methods based thereon
US5248771A (en) * 1991-06-26 1993-09-28 Triumf Process for preparing no-carrier-added radiohalogenated vinyl nucleosides
FI20012151A0 (fi) * 2001-11-05 2001-11-05 Danisco Nestemäinen leivänparannusaine, sen käyttö ja valmistusmenetelmä
EP2488182B1 (en) 2009-10-14 2017-07-19 Elion Oncology LLC Treating neurotoxicity associated with combinations of 5-FU or its prodrugs and DPD inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019638A1 (fr) * 1991-04-24 1992-11-12 Yamasa Shoyu Kabushiki Kaisha DERIVE DE 1-β-D-ARABINOFURANOSYL-(E)-5-(2-HALOGENOVINYL)-URACILE
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
US7618950B2 (en) 2004-07-07 2009-11-17 Arigen Pharmaceuticals, Inc. Method for treatment and prevention of herpes zoster by topical application
JP2007210963A (ja) * 2006-02-10 2007-08-23 Arigen Inc ピリミジンヌクレオシド誘導体及びその塩
WO2008099492A1 (ja) * 2007-02-15 2008-08-21 Arigen Pharmaceuticals, Inc. ピリミジンヌクレオシド誘導体及びその塩
US8076302B2 (en) 2007-02-15 2011-12-13 Arigen Pharmaceuticals, Inc. Pyrimidine nucleoside derivatives and salts thereof

Also Published As

Publication number Publication date
EP0031128B1 (en) 1983-07-13
DE3064165D1 (en) 1983-08-18
US4386076A (en) 1983-05-31
JPS5748160B2 (ja) 1982-10-14
EP0031128A1 (en) 1981-07-01
ES498020A0 (es) 1982-06-01
CA1150247A (en) 1983-07-19
ES8205234A1 (es) 1982-06-01

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