JPS5661360A - 1-substituted imidazole derivative and its preparation - Google Patents

1-substituted imidazole derivative and its preparation

Info

Publication number
JPS5661360A
JPS5661360A JP13699279A JP13699279A JPS5661360A JP S5661360 A JPS5661360 A JP S5661360A JP 13699279 A JP13699279 A JP 13699279A JP 13699279 A JP13699279 A JP 13699279A JP S5661360 A JPS5661360 A JP S5661360A
Authority
JP
Japan
Prior art keywords
formula
oxo
compound
imidazole
vinylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13699279A
Other languages
Japanese (ja)
Other versions
JPS6241507B2 (en
Inventor
Toshio Tanaka
Takeshi Yu
Takeo Oba
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Seiji Kurozumi
Kenji Hoshina
Tatsuyuki Naritomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP13699279A priority Critical patent/JPS5661360A/en
Publication of JPS5661360A publication Critical patent/JPS5661360A/en
Publication of JPS6241507B2 publication Critical patent/JPS6241507B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 1-substituted imidazole derivative of formula I [R is 1W10C alkyl, 5W7C cycloalkyl, phenyl or phenoxyalkyl; A is ethylene or trans-vinylene; Y is oxo (=0) or group formula II.
EXAMPLE: 1-(3-Oxo-1-trans-octenyl)imidazole.
USE: Medicine having pharmacological activities relating to inflammation, e.g. blood platelet coagulation suppressing and thromboxane A2 biosynthesis inhibiting actions, and useful for the prevention of cardiovascular infarction, prevention of post-operative thrombosis, promotion of patency of the transplanted vessel after surgical operation, and remedy for atheroscelrosis, etc.
PROCESS: A compound of formula I wherein A is vinylene and Y is oxo can be prepared by reacting an enone of formula III (X is halogen) with imidazole pref. in a solvent at -20W+100°C. The compound thus prepared can be converted to another compound of formula I wherein A and Y are those other than specified above by reducing with a reducing agent such as lithium aluminum hydride.
COPYRIGHT: (C)1981,JPO&Japio
JP13699279A 1979-10-25 1979-10-25 1-substituted imidazole derivative and its preparation Granted JPS5661360A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13699279A JPS5661360A (en) 1979-10-25 1979-10-25 1-substituted imidazole derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13699279A JPS5661360A (en) 1979-10-25 1979-10-25 1-substituted imidazole derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5661360A true JPS5661360A (en) 1981-05-26
JPS6241507B2 JPS6241507B2 (en) 1987-09-03

Family

ID=15188244

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13699279A Granted JPS5661360A (en) 1979-10-25 1979-10-25 1-substituted imidazole derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5661360A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03115267A (en) * 1989-09-28 1991-05-16 Maruho Kk Propiophenone derivative, its production and central muscle relaxant and antispasmodic agent containing the same
JP2014521652A (en) * 2011-07-29 2014-08-28 カリオファーム セラピューティクス，インコーポレイテッド Hydrazide-containing nuclear transport regulators and uses thereof
JP2015071753A (en) * 2013-09-06 2015-04-16 株式会社Adeka Curing agent and curable resin composition

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03115267A (en) * 1989-09-28 1991-05-16 Maruho Kk Propiophenone derivative, its production and central muscle relaxant and antispasmodic agent containing the same
JP2014521652A (en) * 2011-07-29 2014-08-28 カリオファーム セラピューティクス，インコーポレイテッド Hydrazide-containing nuclear transport regulators and uses thereof
JP2015071753A (en) * 2013-09-06 2015-04-16 株式会社Adeka Curing agent and curable resin composition

Also Published As

Publication number Publication date
JPS6241507B2 (en) 1987-09-03

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