JPS5661328A - Purification of halogenated pyruvic ester - Google Patents
Purification of halogenated pyruvic esterInfo
- Publication number
- JPS5661328A JPS5661328A JP13845679A JP13845679A JPS5661328A JP S5661328 A JPS5661328 A JP S5661328A JP 13845679 A JP13845679 A JP 13845679A JP 13845679 A JP13845679 A JP 13845679A JP S5661328 A JPS5661328 A JP S5661328A
- Authority
- JP
- Japan
- Prior art keywords
- ester
- halogenated
- purification
- epoxy
- halogenated pyruvic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: In the purification of a halogenated pyruvic ester used as a synthetic intermediate of drugs, a compound carrying an epoxy ring is added and they are distilled to improve the yield and purity of the ester without decomposition.
CONSTITUTION: In the presence of an epoxy-bearing compound, a halogenated pyruvic ester of the formula (X is halogen; R is hydrocarbyl) such as ethyl chloropyruvate or ethyl bromopyruvate is distilled to effect purification. The distillation temperature is desired to be as low as possible, because the decomposition does not take place and distillation under reduced pressure is preferred, since the halogenated pyruvic ester boils at a high temperature. The epoxy-bearing compound is preferably the condensated between epichlorohydrin and bisphenol-A and the amount to be added is 0.5W10, preferably 1W5mol% based on the halogenated pyruvic ester and calculated as monoepoxide.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13845679A JPS5661328A (en) | 1979-10-25 | 1979-10-25 | Purification of halogenated pyruvic ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13845679A JPS5661328A (en) | 1979-10-25 | 1979-10-25 | Purification of halogenated pyruvic ester |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5661328A true JPS5661328A (en) | 1981-05-26 |
Family
ID=15222432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13845679A Pending JPS5661328A (en) | 1979-10-25 | 1979-10-25 | Purification of halogenated pyruvic ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5661328A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63203646A (en) * | 1987-02-20 | 1988-08-23 | Musashino Kagaku Kenkyusho:Kk | Stabilization of pyruvic acid and derivative thereof |
US5245062A (en) * | 1990-01-18 | 1993-09-14 | Henkel Kommanditgesellschaft Auf Aktien | Process for the production of ketone compounds |
WO2000026177A1 (en) * | 1998-10-29 | 2000-05-11 | Great Lakes Chemical Corporation | Synthesis of ethyl bromopyruvate |
US6348617B1 (en) | 1996-10-09 | 2002-02-19 | Sumitomo Chemical Company, Limited | Method for purifying pyruvic acid compounds |
JP2005325050A (en) * | 2004-05-14 | 2005-11-24 | Toray Fine Chemicals Co Ltd | Method for storing 2-keto acid ester |
-
1979
- 1979-10-25 JP JP13845679A patent/JPS5661328A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63203646A (en) * | 1987-02-20 | 1988-08-23 | Musashino Kagaku Kenkyusho:Kk | Stabilization of pyruvic acid and derivative thereof |
US5245062A (en) * | 1990-01-18 | 1993-09-14 | Henkel Kommanditgesellschaft Auf Aktien | Process for the production of ketone compounds |
US6348617B1 (en) | 1996-10-09 | 2002-02-19 | Sumitomo Chemical Company, Limited | Method for purifying pyruvic acid compounds |
WO2000026177A1 (en) * | 1998-10-29 | 2000-05-11 | Great Lakes Chemical Corporation | Synthesis of ethyl bromopyruvate |
JP2005325050A (en) * | 2004-05-14 | 2005-11-24 | Toray Fine Chemicals Co Ltd | Method for storing 2-keto acid ester |
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