JPS5661328A - Purification of halogenated pyruvic ester - Google Patents

Purification of halogenated pyruvic ester

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Publication number
JPS5661328A
JPS5661328A JP13845679A JP13845679A JPS5661328A JP S5661328 A JPS5661328 A JP S5661328A JP 13845679 A JP13845679 A JP 13845679A JP 13845679 A JP13845679 A JP 13845679A JP S5661328 A JPS5661328 A JP S5661328A
Authority
JP
Japan
Prior art keywords
ester
halogenated
purification
epoxy
halogenated pyruvic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13845679A
Other languages
Japanese (ja)
Inventor
Hiroyuki Hata
Masao Kawamura
Tadaaki Nishi
Kunioki Kato
Hitoshi Someta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Seika Chemicals Co Ltd
Original Assignee
Seitetsu Kagaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seitetsu Kagaku Co Ltd filed Critical Seitetsu Kagaku Co Ltd
Priority to JP13845679A priority Critical patent/JPS5661328A/en
Publication of JPS5661328A publication Critical patent/JPS5661328A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: In the purification of a halogenated pyruvic ester used as a synthetic intermediate of drugs, a compound carrying an epoxy ring is added and they are distilled to improve the yield and purity of the ester without decomposition.
CONSTITUTION: In the presence of an epoxy-bearing compound, a halogenated pyruvic ester of the formula (X is halogen; R is hydrocarbyl) such as ethyl chloropyruvate or ethyl bromopyruvate is distilled to effect purification. The distillation temperature is desired to be as low as possible, because the decomposition does not take place and distillation under reduced pressure is preferred, since the halogenated pyruvic ester boils at a high temperature. The epoxy-bearing compound is preferably the condensated between epichlorohydrin and bisphenol-A and the amount to be added is 0.5W10, preferably 1W5mol% based on the halogenated pyruvic ester and calculated as monoepoxide.
COPYRIGHT: (C)1981,JPO&Japio
JP13845679A 1979-10-25 1979-10-25 Purification of halogenated pyruvic ester Pending JPS5661328A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13845679A JPS5661328A (en) 1979-10-25 1979-10-25 Purification of halogenated pyruvic ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13845679A JPS5661328A (en) 1979-10-25 1979-10-25 Purification of halogenated pyruvic ester

Publications (1)

Publication Number Publication Date
JPS5661328A true JPS5661328A (en) 1981-05-26

Family

ID=15222432

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13845679A Pending JPS5661328A (en) 1979-10-25 1979-10-25 Purification of halogenated pyruvic ester

Country Status (1)

Country Link
JP (1) JPS5661328A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63203646A (en) * 1987-02-20 1988-08-23 Musashino Kagaku Kenkyusho:Kk Stabilization of pyruvic acid and derivative thereof
US5245062A (en) * 1990-01-18 1993-09-14 Henkel Kommanditgesellschaft Auf Aktien Process for the production of ketone compounds
WO2000026177A1 (en) * 1998-10-29 2000-05-11 Great Lakes Chemical Corporation Synthesis of ethyl bromopyruvate
US6348617B1 (en) 1996-10-09 2002-02-19 Sumitomo Chemical Company, Limited Method for purifying pyruvic acid compounds
JP2005325050A (en) * 2004-05-14 2005-11-24 Toray Fine Chemicals Co Ltd Method for storing 2-keto acid ester

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63203646A (en) * 1987-02-20 1988-08-23 Musashino Kagaku Kenkyusho:Kk Stabilization of pyruvic acid and derivative thereof
US5245062A (en) * 1990-01-18 1993-09-14 Henkel Kommanditgesellschaft Auf Aktien Process for the production of ketone compounds
US6348617B1 (en) 1996-10-09 2002-02-19 Sumitomo Chemical Company, Limited Method for purifying pyruvic acid compounds
WO2000026177A1 (en) * 1998-10-29 2000-05-11 Great Lakes Chemical Corporation Synthesis of ethyl bromopyruvate
JP2005325050A (en) * 2004-05-14 2005-11-24 Toray Fine Chemicals Co Ltd Method for storing 2-keto acid ester

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