JPS57140759A - Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate - Google Patents
Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylateInfo
- Publication number
- JPS57140759A JPS57140759A JP2651881A JP2651881A JPS57140759A JP S57140759 A JPS57140759 A JP S57140759A JP 2651881 A JP2651881 A JP 2651881A JP 2651881 A JP2651881 A JP 2651881A JP S57140759 A JPS57140759 A JP S57140759A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- guanidinocaproic
- ethyl ester
- tosylate salt
- tosylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YKGYIDJEEQRWQH-UHFFFAOYSA-N Gabexate Chemical compound CCOC(=O)C1=CC=C(OC(=O)CCCCCN=C(N)N)C=C1 YKGYIDJEEQRWQH-UHFFFAOYSA-N 0.000 title 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N Ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 abstract 3
- NSDYIDKTTPXCRH-UHFFFAOYSA-N 6-guanidinohexanoic acid Chemical compound NC(=N)NCCCCCC(O)=O NSDYIDKTTPXCRH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- DNTNDFLIKUKKOC-UHFFFAOYSA-N diaminomethylidene-[6-(4-ethoxycarbonylphenoxy)-6-oxohexyl]azanium;methanesulfonate Chemical compound CS([O-])(=O)=O.CCOC(=O)C1=CC=C(OC(=O)CCCCCN=C(N)[NH3+])C=C1 DNTNDFLIKUKKOC-UHFFFAOYSA-N 0.000 abstract 1
- 229950000501 gabexate Drugs 0.000 abstract 1
Abstract
PURPOSE: p-Tosylate salt of mixed acid anhydride of 6-guanidinocaproic acid with p-tosylic acid is made to reat with p-hydroxybenzoic ethyl ester to produce the titled compound used as an intermediate of gabexate mesylate under mild reaction conditions in high yield.
CONSTITUTION: p-Tosylate salt of acid nhydride between 6-guanidinocaproic acid and p-tosylic acid of formula 2 is made to react with p-hydroxybenzoic ethyl ester of formula 3 usually at room temperature to 50°C for about 1 hour to give the objective compound of formulaI. The amount of p-hydroxybenzoic ethyl ester used is equal to or more than the p-tosylate salt in molar quantities.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2651881A JPS57140759A (en) | 1981-02-25 | 1981-02-25 | Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2651881A JPS57140759A (en) | 1981-02-25 | 1981-02-25 | Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57140759A true JPS57140759A (en) | 1982-08-31 |
Family
ID=12195692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2651881A Pending JPS57140759A (en) | 1981-02-25 | 1981-02-25 | Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57140759A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109761858A (en) * | 2019-02-12 | 2019-05-17 | 成都苑东生物制药股份有限公司 | A kind of refining methd of gabexate mesilate |
-
1981
- 1981-02-25 JP JP2651881A patent/JPS57140759A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109761858A (en) * | 2019-02-12 | 2019-05-17 | 成都苑东生物制药股份有限公司 | A kind of refining methd of gabexate mesilate |
| CN109761858B (en) * | 2019-02-12 | 2021-05-14 | 成都苑东生物制药股份有限公司 | Refining method of gabexate mesylate |
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