JPS57140759A - Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate - Google Patents

Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate

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Publication number
JPS57140759A
JPS57140759A JP2651881A JP2651881A JPS57140759A JP S57140759 A JPS57140759 A JP S57140759A JP 2651881 A JP2651881 A JP 2651881A JP 2651881 A JP2651881 A JP 2651881A JP S57140759 A JPS57140759 A JP S57140759A
Authority
JP
Japan
Prior art keywords
acid
guanidinocaproic
ethyl ester
tosylate salt
tosylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2651881A
Other languages
Japanese (ja)
Inventor
Kazuo Satoie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOHO IYAKU KENKYUSHO KK
Original Assignee
TOHO IYAKU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOHO IYAKU KENKYUSHO KK filed Critical TOHO IYAKU KENKYUSHO KK
Priority to JP2651881A priority Critical patent/JPS57140759A/en
Publication of JPS57140759A publication Critical patent/JPS57140759A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: p-Tosylate salt of mixed acid anhydride of 6-guanidinocaproic acid with p-tosylic acid is made to reat with p-hydroxybenzoic ethyl ester to produce the titled compound used as an intermediate of gabexate mesylate under mild reaction conditions in high yield.
CONSTITUTION: p-Tosylate salt of acid nhydride between 6-guanidinocaproic acid and p-tosylic acid of formula 2 is made to react with p-hydroxybenzoic ethyl ester of formula 3 usually at room temperature to 50°C for about 1 hour to give the objective compound of formulaI. The amount of p-hydroxybenzoic ethyl ester used is equal to or more than the p-tosylate salt in molar quantities.
COPYRIGHT: (C)1982,JPO&Japio
JP2651881A 1981-02-25 1981-02-25 Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate Pending JPS57140759A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2651881A JPS57140759A (en) 1981-02-25 1981-02-25 Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2651881A JPS57140759A (en) 1981-02-25 1981-02-25 Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate

Publications (1)

Publication Number Publication Date
JPS57140759A true JPS57140759A (en) 1982-08-31

Family

ID=12195692

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2651881A Pending JPS57140759A (en) 1981-02-25 1981-02-25 Production of 6-guanidinocaproic p-ethoxycarbonylphenyl ester p-tosylate

Country Status (1)

Country Link
JP (1) JPS57140759A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109761858A (en) * 2019-02-12 2019-05-17 成都苑东生物制药股份有限公司 A kind of refining methd of gabexate mesilate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109761858A (en) * 2019-02-12 2019-05-17 成都苑东生物制药股份有限公司 A kind of refining methd of gabexate mesilate
CN109761858B (en) * 2019-02-12 2021-05-14 成都苑东生物制药股份有限公司 Refining method of gabexate mesylate

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