JPS56103177A - Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride - Google Patents
Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochlorideInfo
- Publication number
- JPS56103177A JPS56103177A JP453380A JP453380A JPS56103177A JP S56103177 A JPS56103177 A JP S56103177A JP 453380 A JP453380 A JP 453380A JP 453380 A JP453380 A JP 453380A JP S56103177 A JPS56103177 A JP S56103177A
- Authority
- JP
- Japan
- Prior art keywords
- type
- heated
- homopiperazino
- butyroyl
- dimethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To methanolate or monohydrate of the titled compound is heated to a temperature exceeding the transition point to produce tht titled compound which has sufficient purity to be used as a medicine and low hygroscopicity enough to be stable on preparation.
CONSTITUTION: 2-(N4- n - butyroyl -homopiperazino)-4-amino-6,7-dimethoxy-quinazoline hydrochloride, a useful hypotensor, is subjected to transition between crystal forms, the methanolate (M type), monohydrate (H type), anhydride (A type) and polyhydrate (P type) to collect the A type, which is most suitable for a medicine. The H type is heated in acetone over 60°C or heated in the air at normal pressure above the transition point, 114W125°C and converted to the A type. The M type is converted to the A type by heated it at normal pressure above the transition point, 118W134°C or by converting it to the M type by crystallization from the aqueous solution with acetone and converting the M type to the A type in the same way as described above.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP453380A JPS56103177A (en) | 1980-01-21 | 1980-01-21 | Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP453380A JPS56103177A (en) | 1980-01-21 | 1980-01-21 | Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56103177A true JPS56103177A (en) | 1981-08-18 |
Family
ID=11586676
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP453380A Pending JPS56103177A (en) | 1980-01-21 | 1980-01-21 | Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56103177A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4966690A (en) * | 1972-10-30 | 1974-06-27 | ||
JPS55105680A (en) * | 1979-02-07 | 1980-08-13 | Eisai Co Ltd | Purification of 2-(n4-n-butyroyl-homopiperazino)-4-amino- 6,7-dimethoxy-quinazoline hydrochloride |
-
1980
- 1980-01-21 JP JP453380A patent/JPS56103177A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4966690A (en) * | 1972-10-30 | 1974-06-27 | ||
JPS55105680A (en) * | 1979-02-07 | 1980-08-13 | Eisai Co Ltd | Purification of 2-(n4-n-butyroyl-homopiperazino)-4-amino- 6,7-dimethoxy-quinazoline hydrochloride |
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