JPS56103177A - Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride - Google Patents

Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride

Info

Publication number
JPS56103177A
JPS56103177A JP453380A JP453380A JPS56103177A JP S56103177 A JPS56103177 A JP S56103177A JP 453380 A JP453380 A JP 453380A JP 453380 A JP453380 A JP 453380A JP S56103177 A JPS56103177 A JP S56103177A
Authority
JP
Japan
Prior art keywords
type
heated
homopiperazino
butyroyl
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP453380A
Other languages
Japanese (ja)
Inventor
Kiyoshi Seiji
Kiyohiko Uchikawa
Ukyo Kawabata
Takeo Kanai
Hachiro Sugimoto
Sukeyuki Hamano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP453380A priority Critical patent/JPS56103177A/en
Publication of JPS56103177A publication Critical patent/JPS56103177A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To methanolate or monohydrate of the titled compound is heated to a temperature exceeding the transition point to produce tht titled compound which has sufficient purity to be used as a medicine and low hygroscopicity enough to be stable on preparation.
CONSTITUTION: 2-(N4- n - butyroyl -homopiperazino)-4-amino-6,7-dimethoxy-quinazoline hydrochloride, a useful hypotensor, is subjected to transition between crystal forms, the methanolate (M type), monohydrate (H type), anhydride (A type) and polyhydrate (P type) to collect the A type, which is most suitable for a medicine. The H type is heated in acetone over 60°C or heated in the air at normal pressure above the transition point, 114W125°C and converted to the A type. The M type is converted to the A type by heated it at normal pressure above the transition point, 118W134°C or by converting it to the M type by crystallization from the aqueous solution with acetone and converting the M type to the A type in the same way as described above.
COPYRIGHT: (C)1981,JPO&Japio
JP453380A 1980-01-21 1980-01-21 Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride Pending JPS56103177A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP453380A JPS56103177A (en) 1980-01-21 1980-01-21 Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP453380A JPS56103177A (en) 1980-01-21 1980-01-21 Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride

Publications (1)

Publication Number Publication Date
JPS56103177A true JPS56103177A (en) 1981-08-18

Family

ID=11586676

Family Applications (1)

Application Number Title Priority Date Filing Date
JP453380A Pending JPS56103177A (en) 1980-01-21 1980-01-21 Production of 2- n4-n-butyroyl-homopiperazino -4-amino-6,7- dimethoxy-quinazoline hydrochloride

Country Status (1)

Country Link
JP (1) JPS56103177A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4966690A (en) * 1972-10-30 1974-06-27
JPS55105680A (en) * 1979-02-07 1980-08-13 Eisai Co Ltd Purification of 2-(n4-n-butyroyl-homopiperazino)-4-amino- 6,7-dimethoxy-quinazoline hydrochloride

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4966690A (en) * 1972-10-30 1974-06-27
JPS55105680A (en) * 1979-02-07 1980-08-13 Eisai Co Ltd Purification of 2-(n4-n-butyroyl-homopiperazino)-4-amino- 6,7-dimethoxy-quinazoline hydrochloride

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