JPS5659775A - Preparation of 1- 5-oxohexyl theobromine - Google Patents
Preparation of 1- 5-oxohexyl theobromineInfo
- Publication number
- JPS5659775A JPS5659775A JP13513379A JP13513379A JPS5659775A JP S5659775 A JPS5659775 A JP S5659775A JP 13513379 A JP13513379 A JP 13513379A JP 13513379 A JP13513379 A JP 13513379A JP S5659775 A JPS5659775 A JP S5659775A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- oxohexyl
- theobromine
- halide
- transfer catalyst
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: In the presence of an interphase transfer catalyst, the reaction between an alkali metal salt of theobromine and an oxohexyl halide is conducted to produce the titled compound which is used as a remedy for the sequela of cerebral thrombosis with no formation of by-products, in high yield and purity with industrial advantage.
CONSTITUTION: The reaction of an alkali metal or alkaline earth metal salt of theobromine with an oxohexyl halide formula I (X is halogen) is conducted in the presence of an interphase transfer catalyst in a catalyst amount to produce the titled compound of formula II. The interphase transfer catalyst is, e.g., a compound of formula III (Y- is halide, phosphate, sulfate; R1-4 are alkyl aryl, aralkyl). The amount is 0.01W30 equivalent % based on therbromine, preferably 20W15 equvalent %. The use of benzene or toluene is preferred in the reaction. The reaction is effected at a temperature from room temperature to the boiling point of the solvent, however, a higher temperature promotes the reaction.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13513379A JPS5659775A (en) | 1979-10-22 | 1979-10-22 | Preparation of 1- 5-oxohexyl theobromine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13513379A JPS5659775A (en) | 1979-10-22 | 1979-10-22 | Preparation of 1- 5-oxohexyl theobromine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5659775A true JPS5659775A (en) | 1981-05-23 |
Family
ID=15144571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13513379A Pending JPS5659775A (en) | 1979-10-22 | 1979-10-22 | Preparation of 1- 5-oxohexyl theobromine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5659775A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55102578A (en) * | 1979-01-31 | 1980-08-05 | Shiratori Seiyaku Kk | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
-
1979
- 1979-10-22 JP JP13513379A patent/JPS5659775A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55102578A (en) * | 1979-01-31 | 1980-08-05 | Shiratori Seiyaku Kk | Preparation of 1-(5-oxohexyl)-3,7-dimethylxanthine |
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