JPS5657775A - Thiazole derivative - Google Patents
Thiazole derivativeInfo
- Publication number
- JPS5657775A JPS5657775A JP13448979A JP13448979A JPS5657775A JP S5657775 A JPS5657775 A JP S5657775A JP 13448979 A JP13448979 A JP 13448979A JP 13448979 A JP13448979 A JP 13448979A JP S5657775 A JPS5657775 A JP S5657775A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- thiazole derivative
- halogen
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007979 thiazole derivatives Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- HXRJFTBKCPJNPE-UHFFFAOYSA-N 4-[4-[(4-chlorophenyl)methoxy]phenyl]-n-methyl-1,3-thiazol-2-amine Chemical compound S1C(NC)=NC(C=2C=CC(OCC=3C=CC(Cl)=CC=3)=CC=2)=C1 HXRJFTBKCPJNPE-UHFFFAOYSA-N 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- -1 e.g. Substances 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13448979A JPS5657775A (en) | 1979-10-17 | 1979-10-17 | Thiazole derivative |
| GR63110A GR70379B (Direct) | 1979-10-17 | 1980-10-09 | |
| EP80106271A EP0027957A1 (en) | 1979-10-17 | 1980-10-15 | 2-Amino-4-(4-benzyloxyphenyl)thiazoles, their production and pharmaceutical compositions containing them |
| US06/197,755 US4348403A (en) | 1979-10-17 | 1980-10-16 | 2-Amino-4-(4-benzyloxyphenyl)thiazoles, and their use in hyperlipemia |
| ES495971A ES495971A0 (es) | 1979-10-17 | 1980-10-16 | Procedimiento para obtener derivados de tiazol |
| DK438180A DK438180A (da) | 1979-10-17 | 1980-10-16 | Fremgangsmaade til femstilling af 2-amino-4-(4-benzyloxyfenyl)-thiazoler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13448979A JPS5657775A (en) | 1979-10-17 | 1979-10-17 | Thiazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5657775A true JPS5657775A (en) | 1981-05-20 |
Family
ID=15129514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13448979A Pending JPS5657775A (en) | 1979-10-17 | 1979-10-17 | Thiazole derivative |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4348403A (Direct) |
| EP (1) | EP0027957A1 (Direct) |
| JP (1) | JPS5657775A (Direct) |
| DK (1) | DK438180A (Direct) |
| ES (1) | ES495971A0 (Direct) |
| GR (1) | GR70379B (Direct) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998020871A1 (en) * | 1996-11-08 | 1998-05-22 | Nippon Chemiphar Co., Ltd. | Visceral fat lowering agent |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK305884A (da) * | 1983-06-24 | 1984-12-25 | Yamanouchi Pharma Co Ltd | Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
| EP0320501A3 (en) * | 1983-06-24 | 1989-12-06 | Yamanouchi Pharmaceutical Co., Ltd. | Phenoxy derivatives, their preparation, and pharmaceutical compositions containing them |
| KR20050119201A (ko) * | 2003-04-09 | 2005-12-20 | 니뽄 다바코 산교 가부시키가이샤 | ５원 헤테로방향족 고리 화합물 및 이의 의약적 용도 |
| CN102807586B (zh) | 2012-08-31 | 2015-05-13 | 东北制药集团股份有限公司 | 磷霉素氨盐的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1743083A (en) * | 1928-02-03 | 1930-01-07 | Winthrop Chem Co | Catechol thiazoles and process of making the same |
| FR1567911A (Direct) * | 1967-10-06 | 1969-05-23 | ||
| CH533420A (de) * | 1970-06-23 | 1973-02-15 | Agripat Sa | Mittel zur Regulierung des Pflanzenwachstums und zur Erhöhung des Zuckergehaltes in Zuckerrohr |
| DE2132431A1 (de) * | 1971-06-30 | 1973-01-11 | Riedel De Haen Ag | 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate |
| US4074057A (en) * | 1973-12-12 | 1978-02-14 | Takeda Chemical Co., Ltd. | 2-Halopropionic acid and its derivatives |
| PT65179B (en) * | 1975-06-09 | 1977-11-18 | Takeda Chemical Industries Ltd | Alpha/chlorocarboxylic acids |
-
1979
- 1979-10-17 JP JP13448979A patent/JPS5657775A/ja active Pending
-
1980
- 1980-10-09 GR GR63110A patent/GR70379B/el unknown
- 1980-10-15 EP EP80106271A patent/EP0027957A1/en not_active Withdrawn
- 1980-10-16 ES ES495971A patent/ES495971A0/es active Granted
- 1980-10-16 DK DK438180A patent/DK438180A/da unknown
- 1980-10-16 US US06/197,755 patent/US4348403A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998020871A1 (en) * | 1996-11-08 | 1998-05-22 | Nippon Chemiphar Co., Ltd. | Visceral fat lowering agent |
Also Published As
| Publication number | Publication date |
|---|---|
| DK438180A (da) | 1981-04-18 |
| US4348403A (en) | 1982-09-07 |
| EP0027957A1 (en) | 1981-05-06 |
| GR70379B (Direct) | 1982-10-04 |
| ES8107206A1 (es) | 1981-10-01 |
| ES495971A0 (es) | 1981-10-01 |
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