JPS5646867A - Pyridone derivative, its preparation and antineoplasmic agent - Google Patents

Pyridone derivative, its preparation and antineoplasmic agent

Info

Publication number
JPS5646867A
JPS5646867A JP12202779A JP12202779A JPS5646867A JP S5646867 A JPS5646867 A JP S5646867A JP 12202779 A JP12202779 A JP 12202779A JP 12202779 A JP12202779 A JP 12202779A JP S5646867 A JPS5646867 A JP S5646867A
Authority
JP
Japan
Prior art keywords
formula
compound
antineoplasmic
agent
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12202779A
Other languages
Japanese (ja)
Inventor
Yoshinori Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP12202779A priority Critical patent/JPS5646867A/en
Publication of JPS5646867A publication Critical patent/JPS5646867A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound of formula I (R1 is halogen, alkyl excepting methyl, alkynyl, alkenyl, alkylthiomethyl, cyanoalkyl, aliphatic acyl, alkoxycarbonyl, alkylcarbamoyl, cycloalkylcarbonyl, halogenated carbonyl, aryl etc.).
EXAMPLE: N1-Ethoxymethyl-4-hydroxy-2-pyridone.
USE: Agent used in combination with 5-fluorouracils which are antineoplasmic agents. Synthetic intermediate for 5-fluorouracils.
PROCESS: A compound of formula IV (R4 is R1 or methyl) is obtained by the condensation of a compound of formula Y-R4 (Y is halogen) or formula II (n is 1W2) with a compound of formula III (TMS is trimethylsilyl) in an aprotic organic solvent at 0W100°C for 1W12hr in the presence or absence of a catalyst, followed by the hydrolysis.
COPYRIGHT: (C)1981,JPO&Japio
JP12202779A 1979-09-25 1979-09-25 Pyridone derivative, its preparation and antineoplasmic agent Pending JPS5646867A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12202779A JPS5646867A (en) 1979-09-25 1979-09-25 Pyridone derivative, its preparation and antineoplasmic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12202779A JPS5646867A (en) 1979-09-25 1979-09-25 Pyridone derivative, its preparation and antineoplasmic agent

Publications (1)

Publication Number Publication Date
JPS5646867A true JPS5646867A (en) 1981-04-28

Family

ID=14825770

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12202779A Pending JPS5646867A (en) 1979-09-25 1979-09-25 Pyridone derivative, its preparation and antineoplasmic agent

Country Status (1)

Country Link
JP (1) JPS5646867A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58112571A (en) * 1981-12-28 1983-07-05 株式会社ソフィア Pinball machine
JPS60175281U (en) * 1984-05-01 1985-11-20 株式会社平和 Pachinko machine winning device
EP0180188A2 (en) 1984-10-30 1986-05-07 Otsuka Pharmaceutical Co., Ltd. A composition for increasing the anti-cancer activity of an anti-cancer compound
JPS63301880A (en) * 1985-09-03 1988-12-08 Otsuka Pharmaceut Co Ltd 5-fluorouracil derivative
JPS6425876A (en) * 1987-07-21 1989-01-27 Sankyo Co Pinball game machine
JPH06210053A (en) * 1993-12-08 1994-08-02 Sophia Co Ltd Pinball machine
US5525603A (en) * 1991-05-27 1996-06-11 Taiho Pharmaceutical Co., Ltd. Compositions, methods and kits for potentiating antitumor effect and for treating tumor

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58112571A (en) * 1981-12-28 1983-07-05 株式会社ソフィア Pinball machine
JPS622549B2 (en) * 1981-12-28 1987-01-20 Sofuiya Kk
JPS60175281U (en) * 1984-05-01 1985-11-20 株式会社平和 Pachinko machine winning device
JPH0446783Y2 (en) * 1984-05-01 1992-11-04
EP0180188A2 (en) 1984-10-30 1986-05-07 Otsuka Pharmaceutical Co., Ltd. A composition for increasing the anti-cancer activity of an anti-cancer compound
JPS63301880A (en) * 1985-09-03 1988-12-08 Otsuka Pharmaceut Co Ltd 5-fluorouracil derivative
JPS6425876A (en) * 1987-07-21 1989-01-27 Sankyo Co Pinball game machine
US5525603A (en) * 1991-05-27 1996-06-11 Taiho Pharmaceutical Co., Ltd. Compositions, methods and kits for potentiating antitumor effect and for treating tumor
JPH06210053A (en) * 1993-12-08 1994-08-02 Sophia Co Ltd Pinball machine

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