JPS562913A - Antitumor agent - Google Patents
Antitumor agentInfo
- Publication number
- JPS562913A JPS562913A JP7753779A JP7753779A JPS562913A JP S562913 A JPS562913 A JP S562913A JP 7753779 A JP7753779 A JP 7753779A JP 7753779 A JP7753779 A JP 7753779A JP S562913 A JPS562913 A JP S562913A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- antitumor agent
- dihydroxypyridine
- aryl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: An antitumor agent without increasing the toxicity and side effects, comprising a 5-fluorouracil and 2,4-dihydroxypyridine as active constituents.
CONSTITUTION: An antitumor agent comprising (A) at least one 5-fluorouracil selected from the group consisting of compounds of formula I (R1 and R2 are H, halogen, alkyl, alkynyl, alkenyl, aryl, aliphatic acyl groups, etc.) and of formula II (R3 and R4 are H, alkyl, cycloalkyl, aryl, aralkyl, tetrahydrofurfuryl groups or sugar residues, R3 and R4 are not H at the same time), e.g. N'-ethoxymethyl-5- fluorouracil, and (B) 2,4-dihydroxypyridine at a molar ratio of (A) to (B) of 1:0.01W50, in various forms for oral administration, e.g. a tablet or capsule, or for parenteral administration, e.g. an injection or suppository.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7753779A JPS562913A (en) | 1979-06-21 | 1979-06-21 | Antitumor agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7753779A JPS562913A (en) | 1979-06-21 | 1979-06-21 | Antitumor agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS562913A true JPS562913A (en) | 1981-01-13 |
| JPS6337767B2 JPS6337767B2 (en) | 1988-07-27 |
Family
ID=13636732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7753779A Granted JPS562913A (en) | 1979-06-21 | 1979-06-21 | Antitumor agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS562913A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60199881A (en) * | 1984-03-23 | 1985-10-09 | Nippon Kasei Kk | 5-fluorouracil derivative and its preparation |
| JPS62258367A (en) * | 1986-04-02 | 1987-11-10 | Chisso Corp | 5-fluorouracil derivative and production thereof |
| WO1992021345A1 (en) * | 1991-05-27 | 1992-12-10 | Taiho Pharmaceutical Co., Ltd. | Composition, method and kit for potentiating antitumor activity and for curing tumor |
-
1979
- 1979-06-21 JP JP7753779A patent/JPS562913A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60199881A (en) * | 1984-03-23 | 1985-10-09 | Nippon Kasei Kk | 5-fluorouracil derivative and its preparation |
| JPS62258367A (en) * | 1986-04-02 | 1987-11-10 | Chisso Corp | 5-fluorouracil derivative and production thereof |
| WO1992021345A1 (en) * | 1991-05-27 | 1992-12-10 | Taiho Pharmaceutical Co., Ltd. | Composition, method and kit for potentiating antitumor activity and for curing tumor |
| US5525603A (en) * | 1991-05-27 | 1996-06-11 | Taiho Pharmaceutical Co., Ltd. | Compositions, methods and kits for potentiating antitumor effect and for treating tumor |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6337767B2 (en) | 1988-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI930753A0 (en) | NYA PHOSPHOLIPIDDERIVAT AV NUCLEOSIDER, DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING SAOSOM ANTIVIRALA LAEKEMEDEL | |
| JPS5395977A (en) | 1,4-dihydropyrimidine compounds and process for their preparation | |
| JPS562913A (en) | Antitumor agent | |
| JPS52108028A (en) | Remedies for dysacousis | |
| IL53841A (en) | 3-(3-alkylisoquinol-5-yl)imino)-1,5,10,10a-tetrahydrothiazolo(3,4-b)isoquinoline derivatives,process for their preparation and pharmaceutical compositions containing them | |
| JPS52142054A (en) | 10-amino-9,10-dihyrophenanthrene derivatives and their preparation | |
| JPS5331674A (en) | 5-fluorouracil derivatives and their preparation | |
| JPS51125722A (en) | Germicides for industry and their preparation | |
| JPS525796A (en) | Preparation of tetrahydropyrido pyrimidinone derivatives | |
| JPS55120516A (en) | Antitumor drug comprising organic silicon compound as chief ingredient | |
| JPS5223094A (en) | Preparation of adenine derivatives | |
| JPS5210240A (en) | Preparation of novel antibiotics derivatives | |
| JPS53124241A (en) | Methylenomycin a derivatives and their preparation | |
| JPS52111577A (en) | Diaminomaleonitrile derivatives, their preparation and germicides and herbicides containing the same | |
| JPS5225782A (en) | Preparation of cytidine derivatives | |
| JPS5439061A (en) | Novel thiourea derivatives | |
| JPS5398974A (en) | 1-carbamoyl-5-fluorouracils and process for their preparation | |
| JPS5251362A (en) | Preparation of optically active pyrrolidine derivatives | |
| JPS5350160A (en) | 2-thiazolin-2-ylhydrazine derivatives | |
| JPS53144585A (en) | Novel uracil derivative and process for its preparation | |
| JPS52144645A (en) | Beta-ketosulfoxides and their preparation | |
| JPS53132597A (en) | Cytidylic acid derivative and its preparation | |
| JPS5231079A (en) | Preparation of uracil derivatives | |
| JPS5731618A (en) | Drug composition having antitumor action | |
| JPS53137971A (en) | Bis(iminodiacetaldehyde) derivatives and process for their preparation |