JPS5646808A - Carcinostatic agent - Google Patents
Carcinostatic agentInfo
- Publication number
- JPS5646808A JPS5646808A JP12313579A JP12313579A JPS5646808A JP S5646808 A JPS5646808 A JP S5646808A JP 12313579 A JP12313579 A JP 12313579A JP 12313579 A JP12313579 A JP 12313579A JP S5646808 A JPS5646808 A JP S5646808A
- Authority
- JP
- Japan
- Prior art keywords
- squalene
- derivative
- vitamin
- alcohol
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: The titled agent that contains a squalene derivative and squalene, or a squalene derivatives as the major component, thus showing excellent carcinostatic effect because of its low toxixity and no side-effects in spite of continuous adminisrta tion and further inhibiting the metastatis of cancers effectively by oral administration.
CONSTITUTION: The carcinostatic agent is composed of vitamin A acid and an ester of squalene-ω-alcohol as the major components or of a mixture of squalene and its derivative with vitamin A or its homolog and its derivative as the effective components. The squalene-ω-alcohol is prepared by oxidizine squalene glycol with periodic acid and conducting the Witting reaction of the product, 22-aldehyde of formula I, with 1-ethoxycarbonylethylidene-triphenylphosphoane, finally reducing the resulting ester with a reducing agent such as lithium aluminum hydride. The ester of this alcohol with a vitamin A derivative is obtained by usual esterification.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12313579A JPS6038370B2 (en) | 1979-09-27 | 1979-09-27 | anticancer drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12313579A JPS6038370B2 (en) | 1979-09-27 | 1979-09-27 | anticancer drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5646808A true JPS5646808A (en) | 1981-04-28 |
| JPS6038370B2 JPS6038370B2 (en) | 1985-08-31 |
Family
ID=14853043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12313579A Expired JPS6038370B2 (en) | 1979-09-27 | 1979-09-27 | anticancer drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6038370B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5073572A (en) * | 1990-02-16 | 1991-12-17 | Harbor Branch Oceanographic Institution, Inc. | Bioactive metabolites from cribrochalina vasculum |
| ES2275435A1 (en) * | 2005-11-18 | 2007-06-01 | Farmaleis, S.L. | A combination comprising squalene, a phospholipid and an omega 3 fatty acid for the treatment of cancer |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020004462A1 (en) | 2018-06-29 | 2020-01-02 | 三菱製紙株式会社 | Semipermeable membrane support for membrane bioreactor treatment |
-
1979
- 1979-09-27 JP JP12313579A patent/JPS6038370B2/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5073572A (en) * | 1990-02-16 | 1991-12-17 | Harbor Branch Oceanographic Institution, Inc. | Bioactive metabolites from cribrochalina vasculum |
| ES2275435A1 (en) * | 2005-11-18 | 2007-06-01 | Farmaleis, S.L. | A combination comprising squalene, a phospholipid and an omega 3 fatty acid for the treatment of cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6038370B2 (en) | 1985-08-31 |
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