JPS5634665A - Preparation of 24,25-dihydroxyvitamin d3 - Google Patents

Info

Publication number

JPS5634665A

JPS5634665A JP10905979A JP10905979A JPS5634665A JP S5634665 A JPS5634665 A JP S5634665A JP 10905979 A JP10905979 A JP 10905979A JP 10905979 A JP10905979 A JP 10905979A JP S5634665 A JPS5634665 A JP S5634665A

Authority

JP

Japan

Prior art keywords

formula

hydroxy

oxovitamin

protecting groups

titled compound

Prior art date

1979-08-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• FCKJYANJHNLEEP-XRWYNYHCSA-N (24R)-24,25-dihydroxycalciol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CC[C@@H](O)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C FCKJYANJHNLEEP-XRWYNYHCSA-N 0.000 title 1
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
• 150000001875 compounds Chemical class 0.000 abstract 2
• 125000006239 protecting group Chemical group 0.000 abstract 2
• GBYYUTQUFMMZKJ-HLWWTDDKSA-N (6r)-6-[(9s,10r,13r,14r,17r)-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-hydroxy-2-methylheptan-3-one Chemical compound C1CCC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H](CCC(=O)C(C)(C)O)C)CC[C@H]33)C)C3=CC=C21 GBYYUTQUFMMZKJ-HLWWTDDKSA-N 0.000 abstract 1
• -1 1α- 24 Chemical compound 0.000 abstract 1
• DDZHNKIBJQESJA-AHMPPUFCSA-N 25-hydroxy-24-oxocalciol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCC(=O)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C DDZHNKIBJQESJA-AHMPPUFCSA-N 0.000 abstract 1
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
• UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract 1
• 229910010277 boron hydride Inorganic materials 0.000 abstract 1
• 239000003153 chemical reaction reagent Substances 0.000 abstract 1
• 230000001678 irradiating effect Effects 0.000 abstract 1
• 239000007788 liquid Substances 0.000 abstract 1
• 239000002904 solvent Substances 0.000 abstract 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
• 239000011647 vitamin D3 Substances 0.000 abstract 1
• QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1