JPS5634634A - Stable radiological diagnostic agent labeled with technetium-99m - Google Patents

Stable radiological diagnostic agent labeled with technetium-99m

Info

Publication number
JPS5634634A
JPS5634634A JP11082279A JP11082279A JPS5634634A JP S5634634 A JPS5634634 A JP S5634634A JP 11082279 A JP11082279 A JP 11082279A JP 11082279 A JP11082279 A JP 11082279A JP S5634634 A JPS5634634 A JP S5634634A
Authority
JP
Japan
Prior art keywords
technetium
diagnostic agent
agent
stable
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11082279A
Other languages
Japanese (ja)
Inventor
Akira Yokoyama
Yasushi Arano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON MEJIFUIJITSUKUSU KK
Nihon Medi Physics Co Ltd
Original Assignee
NIPPON MEJIFUIJITSUKUSU KK
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON MEJIFUIJITSUKUSU KK, Nihon Medi Physics Co Ltd filed Critical NIPPON MEJIFUIJITSUKUSU KK
Priority to JP11082279A priority Critical patent/JPS5634634A/en
Priority to EP80100199A priority patent/EP0024464B1/en
Priority to DE8080100199T priority patent/DE3060377D1/en
Priority to US06/113,341 priority patent/US4287362A/en
Priority to CA000343997A priority patent/CA1175418A/en
Priority to AU54721/80A priority patent/AU527412B2/en
Priority to US06/177,947 priority patent/US4338248A/en
Publication of JPS5634634A publication Critical patent/JPS5634634A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

NEW MATERIAL:A nonradioactive carrier formed by condensing 3-oxobutyralbis (N-methylthiosemicarbazone)carboxylic acid of the formula with human serum albumin and the titled diagnostic agent wherein the carrier is combined with technetium-99m.
USE: Useful as radiological applications for the purpose of extraction, dynamic test and quantitative determination of the blood circulation system. Stable for a sufficient period after the preparation compared with the agent wherein the human serum albumin is directly labeled with the technetium-99m. A very high labeling ratio of the technetium-99m and a high concentration in blood for a long time after intravascular administration. Smaller radiation dose (exposure of the subject than the agent labeled with lodine-131.
PROCESS: The nonradioactive carrier is brought into contact with an aqueous solution containing technetium-99m in the form of a pertechnate in the presence of a stannous salt to give the titled diagnostic agent.
COPYRIGHT: (C)1981,JPO&Japio
JP11082279A 1979-08-29 1979-08-29 Stable radiological diagnostic agent labeled with technetium-99m Pending JPS5634634A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP11082279A JPS5634634A (en) 1979-08-29 1979-08-29 Stable radiological diagnostic agent labeled with technetium-99m
EP80100199A EP0024464B1 (en) 1979-08-29 1980-01-16 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use
DE8080100199T DE3060377D1 (en) 1979-08-29 1980-01-16 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use
US06/113,341 US4287362A (en) 1979-08-29 1980-01-18 2-Oxopropionaldehyde bis(thiosemicarbazone) derivatives
CA000343997A CA1175418A (en) 1979-08-29 1980-01-18 2-oxopropionaldehyde bis(thiosemicarbazone) derivatives, and their production and use
AU54721/80A AU527412B2 (en) 1979-08-29 1980-01-18 Thiosemicarbazones and radioactive labelling of proteins
US06/177,947 US4338248A (en) 1979-08-29 1980-08-14 2-Oxopropionaldehyde bis(thiosemicarbazone) protein derivatives, and their production and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11082279A JPS5634634A (en) 1979-08-29 1979-08-29 Stable radiological diagnostic agent labeled with technetium-99m

Publications (1)

Publication Number Publication Date
JPS5634634A true JPS5634634A (en) 1981-04-06

Family

ID=14545529

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11082279A Pending JPS5634634A (en) 1979-08-29 1979-08-29 Stable radiological diagnostic agent labeled with technetium-99m

Country Status (1)

Country Link
JP (1) JPS5634634A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5846027A (en) * 1981-09-14 1983-03-17 Nippon Mejifuijitsukusu Kk Radioactive diagnostic agent for nuclear medicine
JPS63170399A (en) * 1986-12-30 1988-07-14 Nippon Mejifuijitsukusu Kk Radioactive medicine and high polymer compound for preparation thereof
JPS63170389A (en) * 1986-12-30 1988-07-14 Nippon Mejifuijitsukusu Kk Radioactive medicine and high-molecular compound for preparation thereof
JPS63170400A (en) * 1986-12-30 1988-07-14 Nippon Mejifuijitsukusu Kk Radioactive medicine and high polymer compound for preparation thereof
JPH01176000A (en) * 1987-12-30 1989-07-12 Nippon Mejifuijitsukusu Kk Radioactive medicine and polymer compound for preparing said medicine
US5384401A (en) * 1982-12-08 1995-01-24 Nihon Medi-Physics Co., Ltd. Chemical product usable as a non-radioactive carrier

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5846027A (en) * 1981-09-14 1983-03-17 Nippon Mejifuijitsukusu Kk Radioactive diagnostic agent for nuclear medicine
JPH0233018B2 (en) * 1981-09-14 1990-07-25 Nihon Mediphysics Co Ltd
US5384401A (en) * 1982-12-08 1995-01-24 Nihon Medi-Physics Co., Ltd. Chemical product usable as a non-radioactive carrier
JPS63170399A (en) * 1986-12-30 1988-07-14 Nippon Mejifuijitsukusu Kk Radioactive medicine and high polymer compound for preparation thereof
JPS63170389A (en) * 1986-12-30 1988-07-14 Nippon Mejifuijitsukusu Kk Radioactive medicine and high-molecular compound for preparation thereof
JPS63170400A (en) * 1986-12-30 1988-07-14 Nippon Mejifuijitsukusu Kk Radioactive medicine and high polymer compound for preparation thereof
JPH0615478B2 (en) * 1986-12-30 1994-03-02 日本メジフイジックス株式会社 Radiopharmaceuticals and polymeric compounds for their preparation
JPH0623114B2 (en) * 1986-12-30 1994-03-30 日本メジフイジックス株式会社 Radiopharmaceuticals and polymeric compounds for their preparation
JPH01176000A (en) * 1987-12-30 1989-07-12 Nippon Mejifuijitsukusu Kk Radioactive medicine and polymer compound for preparing said medicine

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