JPS5632993A - Antitumorigenic agent and its preparation - Google Patents

Antitumorigenic agent and its preparation

Info

Publication number
JPS5632993A
JPS5632993A JP10852979A JP10852979A JPS5632993A JP S5632993 A JPS5632993 A JP S5632993A JP 10852979 A JP10852979 A JP 10852979A JP 10852979 A JP10852979 A JP 10852979A JP S5632993 A JPS5632993 A JP S5632993A
Authority
JP
Japan
Prior art keywords
afs
substance
produce
mildew
aspergillus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10852979A
Other languages
Japanese (ja)
Other versions
JPS5650954B2 (en
Inventor
Takeo Kinji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP10852979A priority Critical patent/JPS5632993A/en
Publication of JPS5632993A publication Critical patent/JPS5632993A/en
Publication of JPS5650954B2 publication Critical patent/JPS5650954B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

PURPOSE: An mildew that belongs to Aspergillus and can produce the substance AFS is cultured to produce the substance AFS showing remarkable antitumorigenic activity.
CONSTITUTION: An Aspergillus mildew that can produce the substance AFS is cultured under aerobic conditions at 10W45°C for 2W12 days to accumulate the substance AFS in the culture medium. The culture mixture is treated with a combination of filtration, fractional precipitation with an organic solvent, dialysis, solvent extraction, chromatography and so on to isolate the substance AFS. The chemical properties of the substance AFS are as follows: elementary analysis: C: 49.09%, H: 7.165%, O: 27.24%, N: 13.90%, molecular weight: about 4,000 (measured by the vapor-equilibrium mehtod at 60°C); ultraviolet absorption spectrum: the maximum at 280mμ; infrared absorption spectrum: the flgure; solubility in solvents: easily soluble in water, insoluble in ether, chloroform and other solvents; color reaction; ninhydrin test is positive and napthoresorcine test is negative; pH is 6.30 (in 506.4mμ/l aqueous solution).
COPYRIGHT: (C)1981,JPO&Japio
JP10852979A 1979-08-25 1979-08-25 Antitumorigenic agent and its preparation Granted JPS5632993A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10852979A JPS5632993A (en) 1979-08-25 1979-08-25 Antitumorigenic agent and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10852979A JPS5632993A (en) 1979-08-25 1979-08-25 Antitumorigenic agent and its preparation

Publications (2)

Publication Number Publication Date
JPS5632993A true JPS5632993A (en) 1981-04-02
JPS5650954B2 JPS5650954B2 (en) 1981-12-02

Family

ID=14487106

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10852979A Granted JPS5632993A (en) 1979-08-25 1979-08-25 Antitumorigenic agent and its preparation

Country Status (1)

Country Link
JP (1) JPS5632993A (en)

Also Published As

Publication number Publication date
JPS5650954B2 (en) 1981-12-02

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