JPS5632485A - Preparation of organogermanium compound - Google Patents
Preparation of organogermanium compoundInfo
- Publication number
- JPS5632485A JPS5632485A JP10789679A JP10789679A JPS5632485A JP S5632485 A JPS5632485 A JP S5632485A JP 10789679 A JP10789679 A JP 10789679A JP 10789679 A JP10789679 A JP 10789679A JP S5632485 A JPS5632485 A JP S5632485A
- Authority
- JP
- Japan
- Prior art keywords
- germanium
- tetrahalogenide
- trihalogenosilane
- reacted
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 organogermanium compound Chemical class 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052732 germanium Inorganic materials 0.000 abstract 2
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- IEXRMSFAVATTJX-UHFFFAOYSA-N tetrachlorogermane Chemical compound Cl[Ge](Cl)(Cl)Cl IEXRMSFAVATTJX-UHFFFAOYSA-N 0.000 abstract 1
- ZDHXKXAHOVTTAH-UHFFFAOYSA-N trichlorosilane Chemical compound Cl[SiH](Cl)Cl ZDHXKXAHOVTTAH-UHFFFAOYSA-N 0.000 abstract 1
- 239000005052 trichlorosilane Substances 0.000 abstract 1
- 210000001835 viscera Anatomy 0.000 abstract 1
Abstract
PURPOSE: To obtain the titled compound useful for improving the features of diseases, e.g. various intractable diseases, by reacting a germanium tetrahalogenide with a trihalogenosilane in the presence of an organic base, reacting the resultant product with acrylic acid etc., and hydrolyzing the reaction product.
CONSTITUTION: A germanium tetrahalogenide, e.g. germanium tetrachloride, is reacted with a trihalogenosilane, e.g. trichlorosilane, with or without an inert solvent, e.g. benzene, under cooling in an ice bath, in the presence of an organic base, e.g. triethylamine or pyridine. The reaction mixture is then distilled to give the organic salt of a trihalogenogermane as a residue, which is then reacted with acrylic acid or acrylamide in the proesence of an anhydrous solvent, e.g. dioxane, at room temperature, and then hydrolyzed to give the compound of the formula.
USE: Beautifying effects on the skin and anti-inflammatory effects in addition to the treatment of intractable diseases, e.g. concer of the internal organ.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10789679A JPS5632485A (en) | 1979-08-24 | 1979-08-24 | Preparation of organogermanium compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10789679A JPS5632485A (en) | 1979-08-24 | 1979-08-24 | Preparation of organogermanium compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5632485A true JPS5632485A (en) | 1981-04-01 |
| JPS6228797B2 JPS6228797B2 (en) | 1987-06-23 |
Family
ID=14470809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10789679A Granted JPS5632485A (en) | 1979-08-24 | 1979-08-24 | Preparation of organogermanium compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5632485A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4720564A (en) * | 1984-04-25 | 1988-01-19 | Asai Germanium Research Institute | Antioxidant organogermanium compound |
| US5352815A (en) * | 1992-03-16 | 1994-10-04 | Asai Germanium Research Institute Co., Ltd. | Agent for suppression and interception of mailard reaction |
| GB2279650A (en) * | 1992-12-28 | 1995-01-11 | Agency Ind Science Techn | Process for isomerization of compound of aldose structure into compound of ketose structure,and isomerization agent or accelerator used therein |
-
1979
- 1979-08-24 JP JP10789679A patent/JPS5632485A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4720564A (en) * | 1984-04-25 | 1988-01-19 | Asai Germanium Research Institute | Antioxidant organogermanium compound |
| US5352815A (en) * | 1992-03-16 | 1994-10-04 | Asai Germanium Research Institute Co., Ltd. | Agent for suppression and interception of mailard reaction |
| GB2279650A (en) * | 1992-12-28 | 1995-01-11 | Agency Ind Science Techn | Process for isomerization of compound of aldose structure into compound of ketose structure,and isomerization agent or accelerator used therein |
| GB2279650B (en) * | 1992-12-28 | 1996-11-20 | Jp National Food Research Inst | Process for isomerization of compound of aldose structure into compound of ketose structure,and isomerization agent or accelerator used therein |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6228797B2 (en) | 1987-06-23 |
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