JPS56133236A - Sodium valproate clathrate - Google Patents
Sodium valproate clathrateInfo
- Publication number
- JPS56133236A JPS56133236A JP3578780A JP3578780A JPS56133236A JP S56133236 A JPS56133236 A JP S56133236A JP 3578780 A JP3578780 A JP 3578780A JP 3578780 A JP3578780 A JP 3578780A JP S56133236 A JPS56133236 A JP S56133236A
- Authority
- JP
- Japan
- Prior art keywords
- clathrate
- cyclodextrin
- sodium valproate
- sodium
- clathrating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To provide the titled clathrate by clathrating sodium valporate useful as an antiepileptic using cyclodextrin, thereby suppressing the deliquescence of the compound while keeping the high rate of elution thereof from the clathrate.
CONSTITUTION: A sodium valproate clathrate is prepared by clathrating sodium valproate (2-n-propylvaleric acid sodium salt) with cyclodextrin. The amount of sodium valproate is usually 0.5W10mol per 1mol of cyclodextrin. The clathrating procedure is, e.g. as follows. Cyclodextrin and sodium valproate are mixed with water, and if necessary heated to obtain a suspension or solution. When the cyclodextrin is present in the form of dispersion, the composition is mixed thoroughly with a mixer, etc., optionally filtered, and dried to obtain the objective sodium valproate clathrate.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3578780A JPS56133236A (en) | 1980-03-22 | 1980-03-22 | Sodium valproate clathrate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3578780A JPS56133236A (en) | 1980-03-22 | 1980-03-22 | Sodium valproate clathrate |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56133236A true JPS56133236A (en) | 1981-10-19 |
Family
ID=12451615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3578780A Pending JPS56133236A (en) | 1980-03-22 | 1980-03-22 | Sodium valproate clathrate |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56133236A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998040060A1 (en) * | 1997-03-11 | 1998-09-17 | Hexal Ag | Solid, non-deliquescent formulations of sodium valproate |
WO2008090585A3 (en) * | 2007-01-26 | 2009-02-26 | Univ Roma | Soluble forms of inclusion complexes of histone deacetylase inhibitors and cyclodextrins, their preparation processes and uses in the pharmaceutical field |
-
1980
- 1980-03-22 JP JP3578780A patent/JPS56133236A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998040060A1 (en) * | 1997-03-11 | 1998-09-17 | Hexal Ag | Solid, non-deliquescent formulations of sodium valproate |
WO2008090585A3 (en) * | 2007-01-26 | 2009-02-26 | Univ Roma | Soluble forms of inclusion complexes of histone deacetylase inhibitors and cyclodextrins, their preparation processes and uses in the pharmaceutical field |
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