JPS56118099A - Preparation of 7alpha-acylthio-4-en-3-oxosteroid - Google Patents
Preparation of 7alpha-acylthio-4-en-3-oxosteroidInfo
- Publication number
- JPS56118099A JPS56118099A JP2098780A JP2098780A JPS56118099A JP S56118099 A JPS56118099 A JP S56118099A JP 2098780 A JP2098780 A JP 2098780A JP 2098780 A JP2098780 A JP 2098780A JP S56118099 A JPS56118099 A JP S56118099A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- oxosteroid
- diene
- titled compound
- thiocarboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an antialdosteroic diuretic which is an extremely effective remedy, in high yield, by adding a thiocarboxylic acid to 4,6-diene-3-oxosteroid in a specific solvent.
CONSTITUTION: The titled compound is obtained by adding a thiocarboxylic acid (e.g. thioacetic acid) to a 4,6-diene-3-oxosteroid (e.g. 17-hydroxy-3-oxo-17α-pregna- 4,6-diene-21-carboxylic acid γ-lactone, etc.) in a solvent containing N-methyl-2- pyrrolidone or N,N-dimethylacetamide. The reaction may be carried out if necessary, in the presence of a catalytic amount of an acid stronger than the thiocarboxylic acid.
EFFECT: The production of by-product is essentially completely suppressed and the purification efficiency is improved, which result in remarkable economical effects. Stable even by reacting for a long time.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2098780A JPS56118099A (en) | 1980-02-21 | 1980-02-21 | Preparation of 7alpha-acylthio-4-en-3-oxosteroid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2098780A JPS56118099A (en) | 1980-02-21 | 1980-02-21 | Preparation of 7alpha-acylthio-4-en-3-oxosteroid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56118099A true JPS56118099A (en) | 1981-09-16 |
JPS631958B2 JPS631958B2 (en) | 1988-01-14 |
Family
ID=12042484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2098780A Granted JPS56118099A (en) | 1980-02-21 | 1980-02-21 | Preparation of 7alpha-acylthio-4-en-3-oxosteroid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56118099A (en) |
-
1980
- 1980-02-21 JP JP2098780A patent/JPS56118099A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS631958B2 (en) | 1988-01-14 |
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