JPS56118099A - Preparation of 7alpha-acylthio-4-en-3-oxosteroid - Google Patents

Preparation of 7alpha-acylthio-4-en-3-oxosteroid

Info

Publication number
JPS56118099A
JPS56118099A JP2098780A JP2098780A JPS56118099A JP S56118099 A JPS56118099 A JP S56118099A JP 2098780 A JP2098780 A JP 2098780A JP 2098780 A JP2098780 A JP 2098780A JP S56118099 A JPS56118099 A JP S56118099A
Authority
JP
Japan
Prior art keywords
acid
oxosteroid
diene
titled compound
thiocarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2098780A
Other languages
Japanese (ja)
Other versions
JPS631958B2 (en
Inventor
Hiromi Okujima
Shinichiro Fujimori
Rikizo Furuya
Shuzo Hayakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP2098780A priority Critical patent/JPS56118099A/en
Publication of JPS56118099A publication Critical patent/JPS56118099A/en
Publication of JPS631958B2 publication Critical patent/JPS631958B2/ja
Granted legal-status Critical Current

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  • Steroid Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as an antialdosteroic diuretic which is an extremely effective remedy, in high yield, by adding a thiocarboxylic acid to 4,6-diene-3-oxosteroid in a specific solvent.
CONSTITUTION: The titled compound is obtained by adding a thiocarboxylic acid (e.g. thioacetic acid) to a 4,6-diene-3-oxosteroid (e.g. 17-hydroxy-3-oxo-17α-pregna- 4,6-diene-21-carboxylic acid γ-lactone, etc.) in a solvent containing N-methyl-2- pyrrolidone or N,N-dimethylacetamide. The reaction may be carried out if necessary, in the presence of a catalytic amount of an acid stronger than the thiocarboxylic acid.
EFFECT: The production of by-product is essentially completely suppressed and the purification efficiency is improved, which result in remarkable economical effects. Stable even by reacting for a long time.
COPYRIGHT: (C)1981,JPO&Japio
JP2098780A 1980-02-21 1980-02-21 Preparation of 7alpha-acylthio-4-en-3-oxosteroid Granted JPS56118099A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2098780A JPS56118099A (en) 1980-02-21 1980-02-21 Preparation of 7alpha-acylthio-4-en-3-oxosteroid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2098780A JPS56118099A (en) 1980-02-21 1980-02-21 Preparation of 7alpha-acylthio-4-en-3-oxosteroid

Publications (2)

Publication Number Publication Date
JPS56118099A true JPS56118099A (en) 1981-09-16
JPS631958B2 JPS631958B2 (en) 1988-01-14

Family

ID=12042484

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2098780A Granted JPS56118099A (en) 1980-02-21 1980-02-21 Preparation of 7alpha-acylthio-4-en-3-oxosteroid

Country Status (1)

Country Link
JP (1) JPS56118099A (en)

Also Published As

Publication number Publication date
JPS631958B2 (en) 1988-01-14

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