JPS5598113A - Medicinal powder having improved absorbability - Google Patents
Medicinal powder having improved absorbabilityInfo
- Publication number
- JPS5598113A JPS5598113A JP292179A JP292179A JPS5598113A JP S5598113 A JPS5598113 A JP S5598113A JP 292179 A JP292179 A JP 292179A JP 292179 A JP292179 A JP 292179A JP S5598113 A JPS5598113 A JP S5598113A
- Authority
- JP
- Japan
- Prior art keywords
- powder
- drug component
- lymphatic gland
- silica
- micelles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare medicinal powder which can be easily converted to micelles in the digestive tracts even in hungry or in sickness, and has improved absorbability through the lymphatic gland, by covering the surface of silica fine powder with a solid, amorphous, oil-soluble drug component which can be absorbed through the lymphatic gland.
CONSTITUTION: An oil-soluble drug component which is solid at room temperature and absorbable through the lymphatic gland, e.g. coenzyme ubiquinone 10, nicotinic acid dl-α-tocopherol, etc. is dissolved in an organic solvent such as hexane. Fine silica powder is wetted with the solution, and the solvent is removed by heating the mixture at a temperature below the boiling point of the drug component, leaving the drug component as an amorphous layer on the surface of the powder. The weight ratio of the drug to the silica is 1 to 1W15. The composition can be easily converted into micelles in the digestive tracts without adding a surface active agent such as cholic acid salt, etc., and sufficiently high absorbability through the lymphatic gland can be expected.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP292179A JPS5598113A (en) | 1979-01-17 | 1979-01-17 | Medicinal powder having improved absorbability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP292179A JPS5598113A (en) | 1979-01-17 | 1979-01-17 | Medicinal powder having improved absorbability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5598113A true JPS5598113A (en) | 1980-07-25 |
Family
ID=11542807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP292179A Pending JPS5598113A (en) | 1979-01-17 | 1979-01-17 | Medicinal powder having improved absorbability |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5598113A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617294A (en) * | 1985-04-22 | 1986-10-14 | Ppg Industries, Inc. | Animal feed supplement |
| EP0389982A2 (en) * | 1989-03-27 | 1990-10-03 | Lederle (Japan) Ltd. | Anti-peptic ulcer agent |
| JPH05121040A (en) * | 1991-10-31 | 1993-05-18 | Shimadzu Corp | Mass spectrometer |
| WO2005058281A1 (en) * | 2003-12-17 | 2005-06-30 | Schering Corporation | Hydroxysteroid dehydrogenase inhibitors adsorbed on hydrophilic carriers |
-
1979
- 1979-01-17 JP JP292179A patent/JPS5598113A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617294A (en) * | 1985-04-22 | 1986-10-14 | Ppg Industries, Inc. | Animal feed supplement |
| EP0389982A2 (en) * | 1989-03-27 | 1990-10-03 | Lederle (Japan) Ltd. | Anti-peptic ulcer agent |
| JPH02300123A (en) * | 1989-03-27 | 1990-12-12 | Lederle Japan Ltd | Remedy for peptic ulcer |
| JPH05121040A (en) * | 1991-10-31 | 1993-05-18 | Shimadzu Corp | Mass spectrometer |
| WO2005058281A1 (en) * | 2003-12-17 | 2005-06-30 | Schering Corporation | Hydroxysteroid dehydrogenase inhibitors adsorbed on hydrophilic carriers |
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