JPS5587785A - Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog - Google Patents

Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog

Info

Publication number
JPS5587785A
JPS5587785A JP15920778A JP15920778A JPS5587785A JP S5587785 A JPS5587785 A JP S5587785A JP 15920778 A JP15920778 A JP 15920778A JP 15920778 A JP15920778 A JP 15920778A JP S5587785 A JPS5587785 A JP S5587785A
Authority
JP
Japan
Prior art keywords
prostaglandin
formula
agent
mestruation
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15920778A
Other languages
Japanese (ja)
Other versions
JPS6236003B2 (en
Inventor
Hirohisa Wakatsuka
Katsuichi Shimoji
Sadahiko Iguchi
Yoshitaka Konishi
Hisashi Suga
Yasuyuki Miyata
Yoichi Iguchi
Haniroku Miyake
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP15920778A priority Critical patent/JPS5587785A/en
Priority to DE19792947526 priority patent/DE2947526A1/en
Priority to US06/097,675 priority patent/US4367237A/en
Priority to GB7940940A priority patent/GB2038815B/en
Priority to IT27602/79A priority patent/IT1126402B/en
Priority to CH1058679A priority patent/CH643254A5/en
Priority to FR7929261A priority patent/FR2442844A1/en
Publication of JPS5587785A publication Critical patent/JPS5587785A/en
Publication of JPS6236003B2 publication Critical patent/JPS6236003B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: An agent for inducing mestruation, abortion and labor that contains thio-prostaglandin I1 or its analog as the active component, thus having only strong uterine muscle contraction activity and showing substantially no side-effects.
CONSTITUTION: Said agent contains a compound of formula I (Y is ethylene, trans- vinylene; R1 is H, 1W12C alkyl, 7W12C aralkyl; R2 is H, methyl, ethyl; R3 is single bond, 1W4C alkylene; R4 is H, 1W8C alkyl, arbitrarily substituted 4W7C cycloalkyl) or its clathrate with cyclodextrin or its nontoxic salt when R1 is H. The agent is orally or intravaginally administered by 5μgW5mg once or several times. The naturally-occurring prostaglandin I2 of formula II has a wide range of physiological activities as blood platelet coagulation, hypotension, and antitumor, however, the compound of formula I has only uterine muscle contraction activity, thus being used as a medicine.
COPYRIGHT: (C)1980,JPO&Japio
JP15920778A 1978-11-26 1978-12-26 Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog Granted JPS5587785A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP15920778A JPS5587785A (en) 1978-12-26 1978-12-26 Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog
DE19792947526 DE2947526A1 (en) 1978-11-29 1979-11-26 PROSTACYCLIN ANALOGS
US06/097,675 US4367237A (en) 1978-11-26 1979-11-27 Prostacyclin analogues
GB7940940A GB2038815B (en) 1978-11-29 1979-11-27 Prostacyclin analogues
IT27602/79A IT1126402B (en) 1978-11-29 1979-11-27 PROSTACYCLINE ANALOGS
CH1058679A CH643254A5 (en) 1978-11-29 1979-11-28 PROSTAGLANDIN I ANALOGS (1) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR7929261A FR2442844A1 (en) 1978-11-29 1979-11-28 PROSTAGLANDIN I1 ANALOGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15920778A JPS5587785A (en) 1978-12-26 1978-12-26 Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog

Publications (2)

Publication Number Publication Date
JPS5587785A true JPS5587785A (en) 1980-07-02
JPS6236003B2 JPS6236003B2 (en) 1987-08-05

Family

ID=15688652

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15920778A Granted JPS5587785A (en) 1978-11-26 1978-12-26 Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog

Country Status (1)

Country Link
JP (1) JPS5587785A (en)

Also Published As

Publication number Publication date
JPS6236003B2 (en) 1987-08-05

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