JPS5587785A - Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog - Google Patents
Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analogInfo
- Publication number
- JPS5587785A JPS5587785A JP15920778A JP15920778A JPS5587785A JP S5587785 A JPS5587785 A JP S5587785A JP 15920778 A JP15920778 A JP 15920778A JP 15920778 A JP15920778 A JP 15920778A JP S5587785 A JPS5587785 A JP S5587785A
- Authority
- JP
- Japan
- Prior art keywords
- prostaglandin
- formula
- agent
- mestruation
- analog
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: An agent for inducing mestruation, abortion and labor that contains thio-prostaglandin I1 or its analog as the active component, thus having only strong uterine muscle contraction activity and showing substantially no side-effects.
CONSTITUTION: Said agent contains a compound of formula I (Y is ethylene, trans- vinylene; R1 is H, 1W12C alkyl, 7W12C aralkyl; R2 is H, methyl, ethyl; R3 is single bond, 1W4C alkylene; R4 is H, 1W8C alkyl, arbitrarily substituted 4W7C cycloalkyl) or its clathrate with cyclodextrin or its nontoxic salt when R1 is H. The agent is orally or intravaginally administered by 5μgW5mg once or several times. The naturally-occurring prostaglandin I2 of formula II has a wide range of physiological activities as blood platelet coagulation, hypotension, and antitumor, however, the compound of formula I has only uterine muscle contraction activity, thus being used as a medicine.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15920778A JPS5587785A (en) | 1978-12-26 | 1978-12-26 | Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog |
DE19792947526 DE2947526A1 (en) | 1978-11-29 | 1979-11-26 | PROSTACYCLIN ANALOGS |
US06/097,675 US4367237A (en) | 1978-11-26 | 1979-11-27 | Prostacyclin analogues |
GB7940940A GB2038815B (en) | 1978-11-29 | 1979-11-27 | Prostacyclin analogues |
IT27602/79A IT1126402B (en) | 1978-11-29 | 1979-11-27 | PROSTACYCLINE ANALOGS |
CH1058679A CH643254A5 (en) | 1978-11-29 | 1979-11-28 | PROSTAGLANDIN I ANALOGS (1) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
FR7929261A FR2442844A1 (en) | 1978-11-29 | 1979-11-28 | PROSTAGLANDIN I1 ANALOGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15920778A JPS5587785A (en) | 1978-12-26 | 1978-12-26 | Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5587785A true JPS5587785A (en) | 1980-07-02 |
JPS6236003B2 JPS6236003B2 (en) | 1987-08-05 |
Family
ID=15688652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15920778A Granted JPS5587785A (en) | 1978-11-26 | 1978-12-26 | Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5587785A (en) |
-
1978
- 1978-12-26 JP JP15920778A patent/JPS5587785A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6236003B2 (en) | 1987-08-05 |
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