JPS5583739A - Preparation of polypeptide - Google Patents
Preparation of polypeptideInfo
- Publication number
- JPS5583739A JPS5583739A JP15789878A JP15789878A JPS5583739A JP S5583739 A JPS5583739 A JP S5583739A JP 15789878 A JP15789878 A JP 15789878A JP 15789878 A JP15789878 A JP 15789878A JP S5583739 A JPS5583739 A JP S5583739A
- Authority
- JP
- Japan
- Prior art keywords
- endorphin
- protected
- heptadecapeptide
- thr
- condensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare α- or γ-endorphin having morphinic analgesic activity, in high purity and yield, by condensing an N-terminated pentapeptide to the residual undecapeptide (or dodecapetide).
CONSTITUTION: A protected pentapeptide I is reacted with a protected undecapeptide (or dodecapeptide) II (X is Thr or Thr-Leu) to obtain a protected hexadecapeptide (or heptadecapeptide), from which the protection groups are eliminated to obtain the hexadecapiptide (α-endorphin) or the heptadecapeptide (γ-endorphin) of formula III. The synthesis of the compound III is most efficiently carried out by preparing the fragments of the formulas I and II, and condensing the fragments.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15789878A JPS5583739A (en) | 1978-12-18 | 1978-12-18 | Preparation of polypeptide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15789878A JPS5583739A (en) | 1978-12-18 | 1978-12-18 | Preparation of polypeptide |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5583739A true JPS5583739A (en) | 1980-06-24 |
JPS6126920B2 JPS6126920B2 (en) | 1986-06-23 |
Family
ID=15659825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15789878A Granted JPS5583739A (en) | 1978-12-18 | 1978-12-18 | Preparation of polypeptide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5583739A (en) |
-
1978
- 1978-12-18 JP JP15789878A patent/JPS5583739A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6126920B2 (en) | 1986-06-23 |
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