JPS5583739A - Preparation of polypeptide - Google Patents

Preparation of polypeptide

Info

Publication number
JPS5583739A
JPS5583739A JP15789878A JP15789878A JPS5583739A JP S5583739 A JPS5583739 A JP S5583739A JP 15789878 A JP15789878 A JP 15789878A JP 15789878 A JP15789878 A JP 15789878A JP S5583739 A JPS5583739 A JP S5583739A
Authority
JP
Japan
Prior art keywords
endorphin
protected
heptadecapeptide
thr
condensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15789878A
Other languages
Japanese (ja)
Other versions
JPS6126920B2 (en
Inventor
Osamu Nagase
Minoru Kubota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP15789878A priority Critical patent/JPS5583739A/en
Publication of JPS5583739A publication Critical patent/JPS5583739A/en
Publication of JPS6126920B2 publication Critical patent/JPS6126920B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare α- or γ-endorphin having morphinic analgesic activity, in high purity and yield, by condensing an N-terminated pentapeptide to the residual undecapeptide (or dodecapetide).
CONSTITUTION: A protected pentapeptide I is reacted with a protected undecapeptide (or dodecapeptide) II (X is Thr or Thr-Leu) to obtain a protected hexadecapeptide (or heptadecapeptide), from which the protection groups are eliminated to obtain the hexadecapiptide (α-endorphin) or the heptadecapeptide (γ-endorphin) of formula III. The synthesis of the compound III is most efficiently carried out by preparing the fragments of the formulas I and II, and condensing the fragments.
COPYRIGHT: (C)1980,JPO&Japio
JP15789878A 1978-12-18 1978-12-18 Preparation of polypeptide Granted JPS5583739A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15789878A JPS5583739A (en) 1978-12-18 1978-12-18 Preparation of polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15789878A JPS5583739A (en) 1978-12-18 1978-12-18 Preparation of polypeptide

Publications (2)

Publication Number Publication Date
JPS5583739A true JPS5583739A (en) 1980-06-24
JPS6126920B2 JPS6126920B2 (en) 1986-06-23

Family

ID=15659825

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15789878A Granted JPS5583739A (en) 1978-12-18 1978-12-18 Preparation of polypeptide

Country Status (1)

Country Link
JP (1) JPS5583739A (en)

Also Published As

Publication number Publication date
JPS6126920B2 (en) 1986-06-23

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