JPS5573681A - 2-thio substituted-1-carbapenam-3-carboxylic acid derivative and its preparation - Google Patents

2-thio substituted-1-carbapenam-3-carboxylic acid derivative and its preparation

Info

Publication number
JPS5573681A
JPS5573681A JP14846178A JP14846178A JPS5573681A JP S5573681 A JPS5573681 A JP S5573681A JP 14846178 A JP14846178 A JP 14846178A JP 14846178 A JP14846178 A JP 14846178A JP S5573681 A JPS5573681 A JP S5573681A
Authority
JP
Japan
Prior art keywords
compound shown
formula
carbapenam
alkyl
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14846178A
Other languages
Japanese (ja)
Inventor
Tetsuo Hiraoka
Takeo Kobayashi
Taiichiro Watanabe
Toshihiko Hashimoto
Tetsuo Miyadera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP14846178A priority Critical patent/JPS5573681A/en
Publication of JPS5573681A publication Critical patent/JPS5573681A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by the formula I (R1 is H, 1W6C alkyl, OH, acyloxy, etc.; R2 is 1W6C alkyl, aryl, aralkyl, etc.; R3 is H, ester residue, salt- forming group together with carboxyl).
EXAMPLE: 2-(2'-Aminoethyl)mercarto-1-carbapenam-3-carboxylic acid.
USE: Antibiotics and a synthetic intermediate of thienamycin dirivative useful as antibacterial agents.
PROCESS: 1-Carba-2-penam compound shown by the formula II is reacted with a compound shown by the formula R2-S-R4 (R4 is H or alkali metal) in an inert solvent, e.g., THF at -78W30°C to give a compound shown by the fomula I. The addition of a base, e.g., triethylamine, shortens the reaction time extremely. The compound shown by the formula II usable as a starting material is obtained by reacting a compound shown by the formula III (R9 is alkyl, etc.) with a compound shown by the formula IV (X is halogen, etc.).
COPYRIGHT: (C)1980,JPO&Japio
JP14846178A 1978-11-30 1978-11-30 2-thio substituted-1-carbapenam-3-carboxylic acid derivative and its preparation Pending JPS5573681A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14846178A JPS5573681A (en) 1978-11-30 1978-11-30 2-thio substituted-1-carbapenam-3-carboxylic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14846178A JPS5573681A (en) 1978-11-30 1978-11-30 2-thio substituted-1-carbapenam-3-carboxylic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5573681A true JPS5573681A (en) 1980-06-03

Family

ID=15453265

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14846178A Pending JPS5573681A (en) 1978-11-30 1978-11-30 2-thio substituted-1-carbapenam-3-carboxylic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5573681A (en)

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