JPS5545601A - Long-acting cephalexin and its preparation - Google Patents

Long-acting cephalexin and its preparation

Info

Publication number
JPS5545601A
JPS5545601A JP11746778A JP11746778A JPS5545601A JP S5545601 A JPS5545601 A JP S5545601A JP 11746778 A JP11746778 A JP 11746778A JP 11746778 A JP11746778 A JP 11746778A JP S5545601 A JPS5545601 A JP S5545601A
Authority
JP
Japan
Prior art keywords
cephalexin
ethyl cellulose
hardened oil
acting
long
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11746778A
Other languages
Japanese (ja)
Other versions
JPS6213324B2 (en
Inventor
Masaki Hasegawa
Mitsuru Fukushima
Renji Aikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP11746778A priority Critical patent/JPS5545601A/en
Publication of JPS5545601A publication Critical patent/JPS5545601A/en
Publication of JPS6213324B2 publication Critical patent/JPS6213324B2/ja
Granted legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To prepare an excellent long-acting remedy, by compounding cephalexin with a hardened oil and further coating the mixture with ethyl cellulose.
CONSTITUTION: A long-acting granular remedy containing cephalexin and a hardened oil and having an ethyl cellulose coating layer, is prepared by (1) mixing a core substance with a bonding agent (e.g. ethyl cellulose) sprayed to the core in the presence of cephalexin and the hardened oil (e.g. lavery wax), to give the granules, and (2) spraying an ethyl cellulose coating solution to the surface of the granules. Preferably the ratio of cephalexin to the hardened oil is 5:5W3:7 (by weight) and the amount of the ethyl cellulose coated is 2W5wt% on the basis of the total weight. When cephalexin is compounded with a hardened oil and further coated with a protecting layer, elution of cephalexin is prolonged and moderate disintegration is attained to give the maximum concentration of the cephalexin at 4W5hr after administration.
COPYRIGHT: (C)1980,JPO&Japio
JP11746778A 1978-09-26 1978-09-26 Long-acting cephalexin and its preparation Granted JPS5545601A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11746778A JPS5545601A (en) 1978-09-26 1978-09-26 Long-acting cephalexin and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11746778A JPS5545601A (en) 1978-09-26 1978-09-26 Long-acting cephalexin and its preparation

Publications (2)

Publication Number Publication Date
JPS5545601A true JPS5545601A (en) 1980-03-31
JPS6213324B2 JPS6213324B2 (en) 1987-03-25

Family

ID=14712398

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11746778A Granted JPS5545601A (en) 1978-09-26 1978-09-26 Long-acting cephalexin and its preparation

Country Status (1)

Country Link
JP (1) JPS5545601A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS579713A (en) * 1980-06-20 1982-01-19 Toyo Jozo Co Ltd Oral pharmaceutical capable of delayed disintegration in mouth and its preparation
JPS57165392A (en) * 1981-04-06 1982-10-12 Toyo Jozo Co Ltd Long-acting cephalexin tablet
JPS591417A (en) * 1982-06-28 1984-01-06 Toyo Jozo Co Ltd Long-acting cephalexin tablet and its preparation
JPH042052U (en) * 1990-04-21 1992-01-09
US5296232A (en) * 1989-05-05 1994-03-22 Kv Pharmaceutical Company Pharmaceutical formulation which does not induce tolerance
US5445829A (en) * 1989-05-05 1995-08-29 Kv Pharmaceutical Company Extended release pharmaceutical formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52110818A (en) * 1976-03-16 1977-09-17 Yamanouchi Pharmaceut Co Ltd Stable composition containing water-soluble medicine
JPS52139713A (en) * 1976-05-13 1977-11-21 Shionogi & Co Ltd Sustained release cefalexin preparations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52110818A (en) * 1976-03-16 1977-09-17 Yamanouchi Pharmaceut Co Ltd Stable composition containing water-soluble medicine
JPS52139713A (en) * 1976-05-13 1977-11-21 Shionogi & Co Ltd Sustained release cefalexin preparations

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS579713A (en) * 1980-06-20 1982-01-19 Toyo Jozo Co Ltd Oral pharmaceutical capable of delayed disintegration in mouth and its preparation
JPS57165392A (en) * 1981-04-06 1982-10-12 Toyo Jozo Co Ltd Long-acting cephalexin tablet
JPS6321649B2 (en) * 1981-04-06 1988-05-09 Toyo Jozo Kk
JPS591417A (en) * 1982-06-28 1984-01-06 Toyo Jozo Co Ltd Long-acting cephalexin tablet and its preparation
JPH0153648B2 (en) * 1982-06-28 1989-11-15 Toyo Jozo Kk
US5296232A (en) * 1989-05-05 1994-03-22 Kv Pharmaceutical Company Pharmaceutical formulation which does not induce tolerance
US5445829A (en) * 1989-05-05 1995-08-29 Kv Pharmaceutical Company Extended release pharmaceutical formulations
JPH042052U (en) * 1990-04-21 1992-01-09

Also Published As

Publication number Publication date
JPS6213324B2 (en) 1987-03-25

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