JPS552A - Production of vitamin b12 - Google Patents

Production of vitamin b12

Info

Publication number
JPS552A
JPS552A JP1758278A JP1758278A JPS552A JP S552 A JPS552 A JP S552A JP 1758278 A JP1758278 A JP 1758278A JP 1758278 A JP1758278 A JP 1758278A JP S552 A JPS552 A JP S552A
Authority
JP
Japan
Prior art keywords
vitamin
methanol
medium
nocardia
cultured
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1758278A
Other languages
Japanese (ja)
Other versions
JPS5643237B2 (en
Inventor
Teruo Watanabe
Tadao Matsubayashi
Hiroko Tajima
Yasuhiko Kojima
Hideji Nishibashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOBAYASHI RIKAGAKU KENKYUSHO
Kawamura Institute of Chemical Research
DIC Corp
Original Assignee
KOBAYASHI RIKAGAKU KENKYUSHO
Kawamura Institute of Chemical Research
Dainippon Ink and Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOBAYASHI RIKAGAKU KENKYUSHO, Kawamura Institute of Chemical Research, Dainippon Ink and Chemicals Co Ltd filed Critical KOBAYASHI RIKAGAKU KENKYUSHO
Priority to JP1758278A priority Critical patent/JPS552A/en
Publication of JPS552A publication Critical patent/JPS552A/en
Publication of JPS5643237B2 publication Critical patent/JPS5643237B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: A bacterium belonging to Nocardia, which assimilates methanol and produces vitamin B12, is cultured in a medium containing methanol as the main carbon source, thus producing industrially inexpensive vitamin B12 that is an essential nutrient and a remedy for pernicious anemia.
CONSTITUTION: A bacterium belonging to Nocardia, which assimilates methanol and produces vitamin B12, such as Nocardia methanophylus, FERM-4374, is cultured in an enriched medium at a temperature of 35W43°C and a pH of 6.5W7 with an adequate addition of methanol during the cultivation for 1W5 days and the vitamin B12 accumulated in the cells is extracted. The amount of vitamin B12 produced largely depends on the concentration of cobalt in the medium and reaches the maximum when cobalt chloride hexahydrate exists at the concentration of 5mg/l in the medium.
COPYRIGHT: (C)1980,JPO&Japio
JP1758278A 1978-02-20 1978-02-20 Production of vitamin b12 Granted JPS552A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1758278A JPS552A (en) 1978-02-20 1978-02-20 Production of vitamin b12

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1758278A JPS552A (en) 1978-02-20 1978-02-20 Production of vitamin b12

Publications (2)

Publication Number Publication Date
JPS552A true JPS552A (en) 1980-01-05
JPS5643237B2 JPS5643237B2 (en) 1981-10-09

Family

ID=11947893

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1758278A Granted JPS552A (en) 1978-02-20 1978-02-20 Production of vitamin b12

Country Status (1)

Country Link
JP (1) JPS552A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58180956A (en) * 1982-04-16 1983-10-22 Sumitomo Electric Ind Ltd Detector for abnormality of temperature in antenna feeder

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5388393A (en) * 1977-01-11 1978-08-03 Mitsui Petrochem Ind Ltd Preparation of vitamin b12

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5388393A (en) * 1977-01-11 1978-08-03 Mitsui Petrochem Ind Ltd Preparation of vitamin b12

Also Published As

Publication number Publication date
JPS5643237B2 (en) 1981-10-09

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