JPS5526881A - Semisynthesis of insulin - Google Patents

Semisynthesis of insulin

Info

Publication number
JPS5526881A
JPS5526881A JP10058178A JP10058178A JPS5526881A JP S5526881 A JPS5526881 A JP S5526881A JP 10058178 A JP10058178 A JP 10058178A JP 10058178 A JP10058178 A JP 10058178A JP S5526881 A JPS5526881 A JP S5526881A
Authority
JP
Japan
Prior art keywords
insulin
trypsin
protecting group
octapeptide
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10058178A
Other languages
Japanese (ja)
Other versions
JPS5721317B2 (en
Inventor
Takeshi Inoue
Kazuyuki Morihara
Shiyunpei Sakakibara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP10058178A priority Critical patent/JPS5526881A/en
Publication of JPS5526881A publication Critical patent/JPS5526881A/en
Publication of JPS5721317B2 publication Critical patent/JPS5721317B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: The condensation between desocatapeptide and human insulin octapeptide is carried out through enzyme reaction to produce insulin with no side reaction and racemization.
CONSTITUTION: The condensation reaction between (A) desoctapeptide-(B23-B30)- insulin of formula I (R1 is H or amino-protecting group) resulting from treating insulin of a variety of animals with trypsin and (B) human insulin-(B23-B30)- octapeptide of formula II (R2 is amino-protecting group; R3, R4, R5 are H, protecting groups; R6 is hydroxyl group, carboxyl protecting group) is effected by the action of trypsin or trypsin-like compound, then protecting groups are removed.
COPYRIGHT: (C)1980,JPO&Japio
JP10058178A 1978-08-17 1978-08-17 Semisynthesis of insulin Granted JPS5526881A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10058178A JPS5526881A (en) 1978-08-17 1978-08-17 Semisynthesis of insulin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10058178A JPS5526881A (en) 1978-08-17 1978-08-17 Semisynthesis of insulin

Publications (2)

Publication Number Publication Date
JPS5526881A true JPS5526881A (en) 1980-02-26
JPS5721317B2 JPS5721317B2 (en) 1982-05-06

Family

ID=14277846

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10058178A Granted JPS5526881A (en) 1978-08-17 1978-08-17 Semisynthesis of insulin

Country Status (1)

Country Link
JP (1) JPS5526881A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58143751A (en) * 1982-02-19 1983-08-26 日本電熱株式会社 Bed with excretion apparatus

Also Published As

Publication number Publication date
JPS5721317B2 (en) 1982-05-06

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