JPS552633A - Preparation of peptide - Google Patents

Preparation of peptide

Info

Publication number
JPS552633A
JPS552633A JP7482778A JP7482778A JPS552633A JP S552633 A JPS552633 A JP S552633A JP 7482778 A JP7482778 A JP 7482778A JP 7482778 A JP7482778 A JP 7482778A JP S552633 A JPS552633 A JP S552633A
Authority
JP
Japan
Prior art keywords
group
peptide
guanido
mesitylene
sulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7482778A
Other languages
Japanese (ja)
Inventor
Masaharu Takeyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP7482778A priority Critical patent/JPS552633A/en
Publication of JPS552633A publication Critical patent/JPS552633A/en
Pending legal-status Critical Current

Links

Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain peptide having guanido group, by forming a peptide from a starting compound wherein the guanido group is protected by mesitylene-2-sulfonyl group, and by eliminating the protecting group with a methanesulfonic acid, etc.
CONSTITUTION: One equivalent of a starting compound having a guanido group is reacted with 1W2 equivalents of a mesitylene-2-sulfonyl halogenide in the presence of a base to protect the guanido group with the mesitylene-2-sulfonyl group, and changed into a peptide. The protecting group is then eliminated by methanesulfonic or trifluoro-methanesulfonic acid in the presence of anisole to suppress side reactions due to cations formed. The desired guanido group-containing peptide is thus obtained.
EFFECT: Neither impurity formation due to the side reactions nor necessity of special vessels in eliminating the protecting group.
COPYRIGHT: (C)1980,JPO&Japio
JP7482778A 1978-06-22 1978-06-22 Preparation of peptide Pending JPS552633A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7482778A JPS552633A (en) 1978-06-22 1978-06-22 Preparation of peptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7482778A JPS552633A (en) 1978-06-22 1978-06-22 Preparation of peptide

Publications (1)

Publication Number Publication Date
JPS552633A true JPS552633A (en) 1980-01-10

Family

ID=13558536

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7482778A Pending JPS552633A (en) 1978-06-22 1978-06-22 Preparation of peptide

Country Status (1)

Country Link
JP (1) JPS552633A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56158747A (en) * 1980-05-12 1981-12-07 Nippon Shinyaku Co Ltd Polypeptide
JPS56158748A (en) * 1980-05-12 1981-12-07 Nippon Shinyaku Co Ltd Preparation of secretin
JPS5777652A (en) * 1980-11-04 1982-05-15 Takeda Chem Ind Ltd Preparation of peptide and arginine derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51100030A (en) * 1975-02-25 1976-09-03 Takeda Chemical Industries Ltd PEPUCHIDONOSEIZOHO

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51100030A (en) * 1975-02-25 1976-09-03 Takeda Chemical Industries Ltd PEPUCHIDONOSEIZOHO

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56158747A (en) * 1980-05-12 1981-12-07 Nippon Shinyaku Co Ltd Polypeptide
JPS56158748A (en) * 1980-05-12 1981-12-07 Nippon Shinyaku Co Ltd Preparation of secretin
JPS5777652A (en) * 1980-11-04 1982-05-15 Takeda Chem Ind Ltd Preparation of peptide and arginine derivative

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