JPS5522673A - Thiazolidinecarboxylic acid derivative - Google Patents
Thiazolidinecarboxylic acid derivativeInfo
- Publication number
- JPS5522673A JPS5522673A JP9181879A JP9181879A JPS5522673A JP S5522673 A JPS5522673 A JP S5522673A JP 9181879 A JP9181879 A JP 9181879A JP 9181879 A JP9181879 A JP 9181879A JP S5522673 A JPS5522673 A JP S5522673A
- Authority
- JP
- Japan
- Prior art keywords
- thiazolidinecarboxylic acid
- compound
- hypertension
- acid derivative
- trimethoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A thiazolidinecarboxylic acid derivative I or its salt (R is lower alkanoyl; Ar is trimethoxyphenyl, nitrophenyl; the α-carbon in the acyl side chain is S-configuration, and the carbon atom attached to COOH in the thiazolidine ring is R-configuration).
EXAMPLE: 3-[ 3-acetylthio-2(S)-methylpropionyl ]-2-( 3, 4, 5-trimethoxyphenyl )- 4(R)-thiazolidinecarboxylic acid.
USE: Low-toxic antihypertensive effective to suppress the activity of angiotensine I-converting enzyme, and useful for the remedy for essential hypertension, renal hypertension and malignant hypertension.
PROCESS: The compound I is prepared by reacting a compound II (R is lower alkanoyl) or its reactive derivative with a compound III, and if necessary, hydrolyzing the reaction product.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9181879A JPS5522673A (en) | 1979-07-18 | 1979-07-18 | Thiazolidinecarboxylic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9181879A JPS5522673A (en) | 1979-07-18 | 1979-07-18 | Thiazolidinecarboxylic acid derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53085394 Division |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5522673A true JPS5522673A (en) | 1980-02-18 |
Family
ID=14037206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9181879A Pending JPS5522673A (en) | 1979-07-18 | 1979-07-18 | Thiazolidinecarboxylic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5522673A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981002893A1 (en) * | 1980-04-02 | 1981-10-15 | Santen Pharmaceutical Co Ltd | Sulfur-containing acylamino acids |
WO1982002200A1 (en) * | 1980-12-29 | 1982-07-08 | Iwao Jun Ichi | Heterocyclic 5-membered ring compounds |
JPS57170513U (en) * | 1981-04-22 | 1982-10-27 | ||
JPS63150907A (en) * | 1986-12-15 | 1988-06-23 | Ckd Controls Ltd | Solenoid |
-
1979
- 1979-07-18 JP JP9181879A patent/JPS5522673A/en active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981002893A1 (en) * | 1980-04-02 | 1981-10-15 | Santen Pharmaceutical Co Ltd | Sulfur-containing acylamino acids |
WO1982002200A1 (en) * | 1980-12-29 | 1982-07-08 | Iwao Jun Ichi | Heterocyclic 5-membered ring compounds |
EP0067885A1 (en) * | 1980-12-29 | 1982-12-29 | Santen Pharmaceutical Co., Ltd. | Heterocyclic 5-membered ring compounds |
US4464371A (en) * | 1980-12-29 | 1984-08-07 | Santen Pharmaceutical Co., Ltd. | Five-membered heterocyclic compounds |
EP0067885B1 (en) * | 1980-12-29 | 1985-09-04 | Santen Pharmaceutical Co., Ltd. | Heterocyclic 5-membered ring compounds |
JPS57170513U (en) * | 1981-04-22 | 1982-10-27 | ||
JPH0134326Y2 (en) * | 1981-04-22 | 1989-10-19 | ||
JPS63150907A (en) * | 1986-12-15 | 1988-06-23 | Ckd Controls Ltd | Solenoid |
JPH0436566B2 (en) * | 1986-12-15 | 1992-06-16 | Ckd Controls |
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