JPS5522673A - Thiazolidinecarboxylic acid derivative - Google Patents

Thiazolidinecarboxylic acid derivative

Info

Publication number
JPS5522673A
JPS5522673A JP9181879A JP9181879A JPS5522673A JP S5522673 A JPS5522673 A JP S5522673A JP 9181879 A JP9181879 A JP 9181879A JP 9181879 A JP9181879 A JP 9181879A JP S5522673 A JPS5522673 A JP S5522673A
Authority
JP
Japan
Prior art keywords
thiazolidinecarboxylic acid
compound
hypertension
acid derivative
trimethoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9181879A
Other languages
Japanese (ja)
Inventor
Katsuo Arimura
Osamu Murakami
Taichi Oka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP9181879A priority Critical patent/JPS5522673A/en
Publication of JPS5522673A publication Critical patent/JPS5522673A/en
Pending legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A thiazolidinecarboxylic acid derivative I or its salt (R is lower alkanoyl; Ar is trimethoxyphenyl, nitrophenyl; the α-carbon in the acyl side chain is S-configuration, and the carbon atom attached to COOH in the thiazolidine ring is R-configuration).
EXAMPLE: 3-[ 3-acetylthio-2(S)-methylpropionyl ]-2-( 3, 4, 5-trimethoxyphenyl )- 4(R)-thiazolidinecarboxylic acid.
USE: Low-toxic antihypertensive effective to suppress the activity of angiotensine I-converting enzyme, and useful for the remedy for essential hypertension, renal hypertension and malignant hypertension.
PROCESS: The compound I is prepared by reacting a compound II (R is lower alkanoyl) or its reactive derivative with a compound III, and if necessary, hydrolyzing the reaction product.
COPYRIGHT: (C)1980,JPO&Japio
JP9181879A 1979-07-18 1979-07-18 Thiazolidinecarboxylic acid derivative Pending JPS5522673A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9181879A JPS5522673A (en) 1979-07-18 1979-07-18 Thiazolidinecarboxylic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9181879A JPS5522673A (en) 1979-07-18 1979-07-18 Thiazolidinecarboxylic acid derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP53085394 Division

Publications (1)

Publication Number Publication Date
JPS5522673A true JPS5522673A (en) 1980-02-18

Family

ID=14037206

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9181879A Pending JPS5522673A (en) 1979-07-18 1979-07-18 Thiazolidinecarboxylic acid derivative

Country Status (1)

Country Link
JP (1) JPS5522673A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981002893A1 (en) * 1980-04-02 1981-10-15 Santen Pharmaceutical Co Ltd Sulfur-containing acylamino acids
WO1982002200A1 (en) * 1980-12-29 1982-07-08 Iwao Jun Ichi Heterocyclic 5-membered ring compounds
JPS57170513U (en) * 1981-04-22 1982-10-27
JPS63150907A (en) * 1986-12-15 1988-06-23 Ckd Controls Ltd Solenoid

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981002893A1 (en) * 1980-04-02 1981-10-15 Santen Pharmaceutical Co Ltd Sulfur-containing acylamino acids
WO1982002200A1 (en) * 1980-12-29 1982-07-08 Iwao Jun Ichi Heterocyclic 5-membered ring compounds
EP0067885A1 (en) * 1980-12-29 1982-12-29 Santen Pharmaceutical Co., Ltd. Heterocyclic 5-membered ring compounds
US4464371A (en) * 1980-12-29 1984-08-07 Santen Pharmaceutical Co., Ltd. Five-membered heterocyclic compounds
EP0067885B1 (en) * 1980-12-29 1985-09-04 Santen Pharmaceutical Co., Ltd. Heterocyclic 5-membered ring compounds
JPS57170513U (en) * 1981-04-22 1982-10-27
JPH0134326Y2 (en) * 1981-04-22 1989-10-19
JPS63150907A (en) * 1986-12-15 1988-06-23 Ckd Controls Ltd Solenoid
JPH0436566B2 (en) * 1986-12-15 1992-06-16 Ckd Controls

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