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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Application filed by Shionogi and Co LtdfiledCriticalShionogi and Co Ltd
Priority to JP6094479ApriorityCriticalpatent/JPS55153753A/en
Publication of JPS55153753ApublicationCriticalpatent/JPS55153753A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
PURPOSE: To prepare a 5-halogeno-2-methylaminobenzophenone useful as an intermediate for the synthesis of medicines, e.g. diazepam etc., ecomonically, in an industrial scale, by reacting a specific benzophenone derivative with an N-halogenoimide or an N-halogenoamide.
CONSTITUTION: (A) 2-Methylamino-2'-halogenated benzophenone I (X is H or halogen) and (B) an N-halogenoimide (e.g. N-chlorosuccinimide) or an N-halogenoamide (e.g. N-chloroacetamide) are heated and refluxed in a solvent, e.g. tetrahydrofuran. The formed imide or amide is filtered off and thereafter the filtrate is concentrated and the residue is purified e.g. by recrystallization to give the compound II (Y is halogen).
COPYRIGHT: (C)1980,JPO&Japio
JP6094479A1979-05-171979-05-17New synthesis of 5-halogeno-2-methylaminobenzophenone
PendingJPS55153753A
(en)
SUBSTITUTED ALKYLAMINO DERIVATIVES OF 6,11-DIHYDRO-11-OXO-DIBENZ (B, E) -OXEPIN, PROCESS FOR THE PRODUCTION THEREOF, THEIR INTERMEDIATE PRODUCTS AND THEIR USE AS A MEDICINAL PRODUCT.
PROCESS FOR THE PREPARATION OF BETA- (FLUOROMETHYLENE) -5-HYDROXYTRYPTOPHAN AND DERIVATIVES AS PRODRUGS FOR MAO INHIBITION AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME