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Application filed by Farmaceutsko-Hemijska Industrija "Zdravlje"filedCriticalFarmaceutsko-Hemijska Industrija "Zdravlje"
Priority to YU83192ApriorityCriticalpatent/YU48455B/en
Publication of YU83192ApublicationCriticalpatent/YU83192A/en
Publication of YU48455BpublicationCriticalpatent/YU48455B/en
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur
(AREA)
Abstract
POSTUPAK ZA SINTEZU IZOSORBID-5-MONONITRATA - Razvijen je jednostavan i za industrijsku primenu pogodan postupak dobijanja izosorbid-5-monbnitrata reakcijom između izosorbida i anhidrida mravlje kiseline uz refluks u toluolu i prisustvu p-toluolsulfonSke kiseline, a zatim nitrovanjem i hidrolizom do željenog proizvoda, u visokom prinosu i visokog stepena čistoce koji omogućava njegovu primenu kao koronarnog vazodilatatora.PROCEDURE FOR ISOSORBID-5-MONONITRATE SYNTHESIS - An easy-to-use industrial process for the preparation of isosorbide-5-monbnitrate by reaction between isosorbide and formic anhydride with reflux in toluene and the presence of p-toluenesulfonic acid and then hydrolysis of the product with hydrolysis of the product , in high yield and high purity that enables its use as a coronary vasodilator.
YU83192A1992-09-111992-09-11Process for preparation of isosorbide-5-mononitrate
YU48455B
(en)
Derivatives of substituted 2-alkylthio-4,5-dimethyl-3-ethylthiazolium as intermediate product for the synthesis of nulmetinmerocyanine dyes, process fro the preparation thereof and process for the production of dyes based thereon