JPS55136255A - Preparation of 2-anilinophenylacetic acid - Google Patents

Preparation of 2-anilinophenylacetic acid

Info

Publication number
JPS55136255A
JPS55136255A JP14280878A JP14280878A JPS55136255A JP S55136255 A JPS55136255 A JP S55136255A JP 14280878 A JP14280878 A JP 14280878A JP 14280878 A JP14280878 A JP 14280878A JP S55136255 A JPS55136255 A JP S55136255A
Authority
JP
Japan
Prior art keywords
formula
solvent
compound
acetic acid
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14280878A
Other languages
Japanese (ja)
Other versions
JPS6256863B2 (en
Inventor
Keisuke Yagami
Isao Sakano
Atsushi Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP14280878A priority Critical patent/JPS55136255A/en
Publication of JPS55136255A publication Critical patent/JPS55136255A/en
Publication of JPS6256863B2 publication Critical patent/JPS6256863B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound having antiphlogistic action, analgesic action and antipyretic action, in an industrial scale, economically, by the halogenation of new N-(2,6-dichlorophenyl)-iminocyclohexane-2-acetic acid, followed by the dehydrohalogenation.
CONSTITUTION: New N-(2,6-dichlorophenyl)iminocyclohexane-2-acetic acid of formula I is halogenated in a solvent such as a halogenated hydrocarbon in the presence of a halogenating atent (e.g. molecular halogen, N-halogenoamides), to obtain a compound of formula II (X is halogen). Subsequently, the compound of formula II is dehydrohalogenated without a solvent or in a solvent such as pyridine or acetic acid, to obtain the desired compound of formula III. The dehydrohalogenation is accelerated by the addition of a dewis acid or an inorganic salt such as lithium chloride.
COPYRIGHT: (C)1980,JPO&Japio
JP14280878A 1978-11-21 1978-11-21 Preparation of 2-anilinophenylacetic acid Granted JPS55136255A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14280878A JPS55136255A (en) 1978-11-21 1978-11-21 Preparation of 2-anilinophenylacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14280878A JPS55136255A (en) 1978-11-21 1978-11-21 Preparation of 2-anilinophenylacetic acid

Publications (2)

Publication Number Publication Date
JPS55136255A true JPS55136255A (en) 1980-10-23
JPS6256863B2 JPS6256863B2 (en) 1987-11-27

Family

ID=15324109

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14280878A Granted JPS55136255A (en) 1978-11-21 1978-11-21 Preparation of 2-anilinophenylacetic acid

Country Status (1)

Country Link
JP (1) JPS55136255A (en)

Also Published As

Publication number Publication date
JPS6256863B2 (en) 1987-11-27

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