JPS55136255A - Preparation of 2-anilinophenylacetic acid - Google Patents
Preparation of 2-anilinophenylacetic acidInfo
- Publication number
- JPS55136255A JPS55136255A JP14280878A JP14280878A JPS55136255A JP S55136255 A JPS55136255 A JP S55136255A JP 14280878 A JP14280878 A JP 14280878A JP 14280878 A JP14280878 A JP 14280878A JP S55136255 A JPS55136255 A JP S55136255A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- solvent
- compound
- acetic acid
- action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound having antiphlogistic action, analgesic action and antipyretic action, in an industrial scale, economically, by the halogenation of new N-(2,6-dichlorophenyl)-iminocyclohexane-2-acetic acid, followed by the dehydrohalogenation.
CONSTITUTION: New N-(2,6-dichlorophenyl)iminocyclohexane-2-acetic acid of formula I is halogenated in a solvent such as a halogenated hydrocarbon in the presence of a halogenating atent (e.g. molecular halogen, N-halogenoamides), to obtain a compound of formula II (X is halogen). Subsequently, the compound of formula II is dehydrohalogenated without a solvent or in a solvent such as pyridine or acetic acid, to obtain the desired compound of formula III. The dehydrohalogenation is accelerated by the addition of a dewis acid or an inorganic salt such as lithium chloride.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14280878A JPS55136255A (en) | 1978-11-21 | 1978-11-21 | Preparation of 2-anilinophenylacetic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14280878A JPS55136255A (en) | 1978-11-21 | 1978-11-21 | Preparation of 2-anilinophenylacetic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55136255A true JPS55136255A (en) | 1980-10-23 |
JPS6256863B2 JPS6256863B2 (en) | 1987-11-27 |
Family
ID=15324109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14280878A Granted JPS55136255A (en) | 1978-11-21 | 1978-11-21 | Preparation of 2-anilinophenylacetic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55136255A (en) |
-
1978
- 1978-11-21 JP JP14280878A patent/JPS55136255A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6256863B2 (en) | 1987-11-27 |
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