JPS55133346A - Preparation of labeled peptide - Google Patents

Preparation of labeled peptide

Info

Publication number
JPS55133346A
JPS55133346A JP3977879A JP3977879A JPS55133346A JP S55133346 A JPS55133346 A JP S55133346A JP 3977879 A JP3977879 A JP 3977879A JP 3977879 A JP3977879 A JP 3977879A JP S55133346 A JPS55133346 A JP S55133346A
Authority
JP
Japan
Prior art keywords
peptide
labeled
give
compound
residual group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3977879A
Other languages
Japanese (ja)
Other versions
JPS6227080B2 (en
Inventor
Fumio Sakiyama
Takashi Nakazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP3977879A priority Critical patent/JPS55133346A/en
Publication of JPS55133346A publication Critical patent/JPS55133346A/en
Publication of JPS6227080B2 publication Critical patent/JPS6227080B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare a labeled peptide extremely useful for the investigation of in vivo metabolism and peptide hormone, economically and advantageously in an industrial scale, by labeling C-2 position of the tryptophan residual group in a peptide with potassium cyanide [13C or 14C], etc.
CONSTITUTION: A peptide I (A and B are amino acid, peptide residual group or their derivatives prepared by protecting their N or C ends with protective groups) is oxidized (e.g. ozone oxidation) to give the N-formylkynurenine derivative II. The compound II is reacted with an alkali metal cyanide labeled with 13C or 14C in a solvent to give the peptide having 2-aminoindolenine nucleus III (*mark exhibits the position labeled with 13C or 14C). The compound III is reacted with a hydride reagent (e.g. sodium borohydride, etc.) at 0W40°C under the condition of pH 7W 10 to give the compound IV having the tryptophan residual group labeled at C-2 position.
COPYRIGHT: (C)1980,JPO&Japio
JP3977879A 1979-04-04 1979-04-04 Preparation of labeled peptide Granted JPS55133346A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3977879A JPS55133346A (en) 1979-04-04 1979-04-04 Preparation of labeled peptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3977879A JPS55133346A (en) 1979-04-04 1979-04-04 Preparation of labeled peptide

Publications (2)

Publication Number Publication Date
JPS55133346A true JPS55133346A (en) 1980-10-17
JPS6227080B2 JPS6227080B2 (en) 1987-06-12

Family

ID=12562386

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3977879A Granted JPS55133346A (en) 1979-04-04 1979-04-04 Preparation of labeled peptide

Country Status (1)

Country Link
JP (1) JPS55133346A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980926B2 (en) 2009-10-30 2015-03-17 Genzyme Corporation 2-aminoindole compounds and methods for the treatment of malaria

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980926B2 (en) 2009-10-30 2015-03-17 Genzyme Corporation 2-aminoindole compounds and methods for the treatment of malaria

Also Published As

Publication number Publication date
JPS6227080B2 (en) 1987-06-12

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