JPS5513204A - Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation - Google Patents
Active compound having delayed allergic activity and anticarcinogenic activity, and its preparationInfo
- Publication number
- JPS5513204A JPS5513204A JP7737078A JP7737078A JPS5513204A JP S5513204 A JPS5513204 A JP S5513204A JP 7737078 A JP7737078 A JP 7737078A JP 7737078 A JP7737078 A JP 7737078A JP S5513204 A JPS5513204 A JP S5513204A
- Authority
- JP
- Japan
- Prior art keywords
- mycobacterium
- active compound
- activity
- nucleic acid
- anticarcinogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
NEW MATERIAL:The title active compound which is obtained by removing nucleic acid and low active proteins from a cell-free extraction solution obtained by disintegrating the cells of bacteria belonging to Mycobacterium, Corynebacterium, Nocardia genus or Micrococcus rhodochrous.
USE: Anticarcinogenic drug having high anticarcinogenic activity and extremely low toxicity, and capable of being administered for a long term safely without side effects or immunogenesis.
PROCESS: Cells of bacteria belonging to Mycobacterium, Corynebacterium, Nocardia, or Micrococcus rhodochrous, are thoroughly mixed in a proper buffer solution and disintegrated under ice-cooling to give a suspension. The bacterial cells and cell walls are removed from the suspension by filtration or centrifuge to give a cell-free extraction solution. Then the nucleic acid is precipitated and removed, using a nucleic acid precipitant. The low active proteins are removed by salting out or isoelectric point precipitation, etc. to affrod the objective active compound. The bacteria are, e.g. Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium smegatis, etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7737078A JPS5513204A (en) | 1978-06-28 | 1978-06-28 | Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7737078A JPS5513204A (en) | 1978-06-28 | 1978-06-28 | Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5513204A true JPS5513204A (en) | 1980-01-30 |
Family
ID=13632002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7737078A Pending JPS5513204A (en) | 1978-06-28 | 1978-06-28 | Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5513204A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57165319A (en) * | 1980-03-25 | 1982-10-12 | Madaus & Co Dr | Manufacture of cell-wall or whole cell medicine in tumor radiative or chemical treatment |
JPS57163835U (en) * | 1981-04-07 | 1982-10-15 | ||
WO2003049751A1 (en) * | 2001-12-10 | 2003-06-19 | Bakulesh Mafatlal Khamar | The process of manufacturing a pharmaceutical composition useful for management of cancer |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5266691A (en) * | 1975-11-26 | 1977-06-02 | Ajinomoto Co Inc | Preparation of carcinostatic agent |
-
1978
- 1978-06-28 JP JP7737078A patent/JPS5513204A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5266691A (en) * | 1975-11-26 | 1977-06-02 | Ajinomoto Co Inc | Preparation of carcinostatic agent |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57165319A (en) * | 1980-03-25 | 1982-10-12 | Madaus & Co Dr | Manufacture of cell-wall or whole cell medicine in tumor radiative or chemical treatment |
JPH0355448B2 (en) * | 1980-03-25 | 1991-08-23 | ||
JPS57163835U (en) * | 1981-04-07 | 1982-10-15 | ||
WO2003049751A1 (en) * | 2001-12-10 | 2003-06-19 | Bakulesh Mafatlal Khamar | The process of manufacturing a pharmaceutical composition useful for management of cancer |
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