JPS5513204A - Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation - Google Patents

Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation

Info

Publication number
JPS5513204A
JPS5513204A JP7737078A JP7737078A JPS5513204A JP S5513204 A JPS5513204 A JP S5513204A JP 7737078 A JP7737078 A JP 7737078A JP 7737078 A JP7737078 A JP 7737078A JP S5513204 A JPS5513204 A JP S5513204A
Authority
JP
Japan
Prior art keywords
mycobacterium
active compound
activity
nucleic acid
anticarcinogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7737078A
Other languages
Japanese (ja)
Inventor
Tadashi Sudo
Osamu Yano
Tamotsu Fukuda
Hitoshi Inoue
Hayao Abe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP7737078A priority Critical patent/JPS5513204A/en
Publication of JPS5513204A publication Critical patent/JPS5513204A/en
Pending legal-status Critical Current

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Landscapes

  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

NEW MATERIAL:The title active compound which is obtained by removing nucleic acid and low active proteins from a cell-free extraction solution obtained by disintegrating the cells of bacteria belonging to Mycobacterium, Corynebacterium, Nocardia genus or Micrococcus rhodochrous.
USE: Anticarcinogenic drug having high anticarcinogenic activity and extremely low toxicity, and capable of being administered for a long term safely without side effects or immunogenesis.
PROCESS: Cells of bacteria belonging to Mycobacterium, Corynebacterium, Nocardia, or Micrococcus rhodochrous, are thoroughly mixed in a proper buffer solution and disintegrated under ice-cooling to give a suspension. The bacterial cells and cell walls are removed from the suspension by filtration or centrifuge to give a cell-free extraction solution. Then the nucleic acid is precipitated and removed, using a nucleic acid precipitant. The low active proteins are removed by salting out or isoelectric point precipitation, etc. to affrod the objective active compound. The bacteria are, e.g. Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium smegatis, etc.
COPYRIGHT: (C)1980,JPO&Japio
JP7737078A 1978-06-28 1978-06-28 Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation Pending JPS5513204A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7737078A JPS5513204A (en) 1978-06-28 1978-06-28 Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7737078A JPS5513204A (en) 1978-06-28 1978-06-28 Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation

Publications (1)

Publication Number Publication Date
JPS5513204A true JPS5513204A (en) 1980-01-30

Family

ID=13632002

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7737078A Pending JPS5513204A (en) 1978-06-28 1978-06-28 Active compound having delayed allergic activity and anticarcinogenic activity, and its preparation

Country Status (1)

Country Link
JP (1) JPS5513204A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57165319A (en) * 1980-03-25 1982-10-12 Madaus & Co Dr Manufacture of cell-wall or whole cell medicine in tumor radiative or chemical treatment
JPS57163835U (en) * 1981-04-07 1982-10-15
WO2003049751A1 (en) * 2001-12-10 2003-06-19 Bakulesh Mafatlal Khamar The process of manufacturing a pharmaceutical composition useful for management of cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5266691A (en) * 1975-11-26 1977-06-02 Ajinomoto Co Inc Preparation of carcinostatic agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5266691A (en) * 1975-11-26 1977-06-02 Ajinomoto Co Inc Preparation of carcinostatic agent

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57165319A (en) * 1980-03-25 1982-10-12 Madaus & Co Dr Manufacture of cell-wall or whole cell medicine in tumor radiative or chemical treatment
JPH0355448B2 (en) * 1980-03-25 1991-08-23
JPS57163835U (en) * 1981-04-07 1982-10-15
WO2003049751A1 (en) * 2001-12-10 2003-06-19 Bakulesh Mafatlal Khamar The process of manufacturing a pharmaceutical composition useful for management of cancer

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