JPS55124736A - Preparation of dihydro-coenzyme q diacetate - Google Patents
Preparation of dihydro-coenzyme q diacetateInfo
- Publication number
- JPS55124736A JPS55124736A JP3177479A JP3177479A JPS55124736A JP S55124736 A JPS55124736 A JP S55124736A JP 3177479 A JP3177479 A JP 3177479A JP 3177479 A JP3177479 A JP 3177479A JP S55124736 A JPS55124736 A JP S55124736A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- coenzyme
- diacetate
- bromide
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound, useful as an intermediate of coenzyme Q, in high yield, by the reaction of a π-allylnickel complex and a bromide.
CONSTITUTION: A π-allylnickel complex of formula I [R is formula II (m=0-2)], e.g. a reaction product of 6-( 4'-bromo-3'-methyl-2'-butenyl )-2,3-dimethoxy-5- methyl-1,4-hydroquinone diacetate and nickel carbonyl, is made to react with a bromide of formula III (n=0-9; m+n≤10), e.g. solasyl bromide, to give the objective compound of formula IV (e.g. dihydro-coenzyme Q10 diacetate). The objective compound of formula IV can be readily converted to coenzyme Q of formula V by the saponification and the oxidation.
EFFECT: Increases the content of trans-isomers that is necessary for the preparation of highly bioactive quinones.
USE: The conenzyme Q10 (m+n=8) is a therapeutic of hypertension, congestive cardiac insufficiency, etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3177479A JPS55124736A (en) | 1979-03-20 | 1979-03-20 | Preparation of dihydro-coenzyme q diacetate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3177479A JPS55124736A (en) | 1979-03-20 | 1979-03-20 | Preparation of dihydro-coenzyme q diacetate |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55124736A true JPS55124736A (en) | 1980-09-26 |
JPS6231700B2 JPS6231700B2 (en) | 1987-07-09 |
Family
ID=12340391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3177479A Granted JPS55124736A (en) | 1979-03-20 | 1979-03-20 | Preparation of dihydro-coenzyme q diacetate |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55124736A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63156400U (en) * | 1987-04-01 | 1988-10-13 | ||
JPS63187700U (en) * | 1987-05-27 | 1988-12-01 | ||
US9518004B2 (en) | 2012-12-03 | 2016-12-13 | Kaneka Corporation | Reduced coenzyme Q10 derivative and method for production thereof |
-
1979
- 1979-03-20 JP JP3177479A patent/JPS55124736A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6231700B2 (en) | 1987-07-09 |
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