JPS55124736A - Preparation of dihydro-coenzyme q diacetate - Google Patents

Preparation of dihydro-coenzyme q diacetate

Info

Publication number
JPS55124736A
JPS55124736A JP3177479A JP3177479A JPS55124736A JP S55124736 A JPS55124736 A JP S55124736A JP 3177479 A JP3177479 A JP 3177479A JP 3177479 A JP3177479 A JP 3177479A JP S55124736 A JPS55124736 A JP S55124736A
Authority
JP
Japan
Prior art keywords
formula
coenzyme
diacetate
bromide
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3177479A
Other languages
Japanese (ja)
Other versions
JPS6231700B2 (en
Inventor
Kikumasa Sato
Seiichi Inoue
Michiya Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP3177479A priority Critical patent/JPS55124736A/en
Publication of JPS55124736A publication Critical patent/JPS55124736A/en
Publication of JPS6231700B2 publication Critical patent/JPS6231700B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound, useful as an intermediate of coenzyme Q, in high yield, by the reaction of a π-allylnickel complex and a bromide.
CONSTITUTION: A π-allylnickel complex of formula I [R is formula II (m=0-2)], e.g. a reaction product of 6-( 4'-bromo-3'-methyl-2'-butenyl )-2,3-dimethoxy-5- methyl-1,4-hydroquinone diacetate and nickel carbonyl, is made to react with a bromide of formula III (n=0-9; m+n≤10), e.g. solasyl bromide, to give the objective compound of formula IV (e.g. dihydro-coenzyme Q10 diacetate). The objective compound of formula IV can be readily converted to coenzyme Q of formula V by the saponification and the oxidation.
EFFECT: Increases the content of trans-isomers that is necessary for the preparation of highly bioactive quinones.
USE: The conenzyme Q10 (m+n=8) is a therapeutic of hypertension, congestive cardiac insufficiency, etc.
COPYRIGHT: (C)1980,JPO&Japio
JP3177479A 1979-03-20 1979-03-20 Preparation of dihydro-coenzyme q diacetate Granted JPS55124736A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3177479A JPS55124736A (en) 1979-03-20 1979-03-20 Preparation of dihydro-coenzyme q diacetate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3177479A JPS55124736A (en) 1979-03-20 1979-03-20 Preparation of dihydro-coenzyme q diacetate

Publications (2)

Publication Number Publication Date
JPS55124736A true JPS55124736A (en) 1980-09-26
JPS6231700B2 JPS6231700B2 (en) 1987-07-09

Family

ID=12340391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3177479A Granted JPS55124736A (en) 1979-03-20 1979-03-20 Preparation of dihydro-coenzyme q diacetate

Country Status (1)

Country Link
JP (1) JPS55124736A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63156400U (en) * 1987-04-01 1988-10-13
JPS63187700U (en) * 1987-05-27 1988-12-01
US9518004B2 (en) 2012-12-03 2016-12-13 Kaneka Corporation Reduced coenzyme Q10 derivative and method for production thereof

Also Published As

Publication number Publication date
JPS6231700B2 (en) 1987-07-09

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