JPS55120586A - Novel mitomycins and their preparation - Google Patents

Novel mitomycins and their preparation

Info

Publication number
JPS55120586A
JPS55120586A JP2675179A JP2675179A JPS55120586A JP S55120586 A JPS55120586 A JP S55120586A JP 2675179 A JP2675179 A JP 2675179A JP 2675179 A JP2675179 A JP 2675179A JP S55120586 A JPS55120586 A JP S55120586A
Authority
JP
Japan
Prior art keywords
mitomycins
novel
preparation
acid chloride
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2675179A
Other languages
Japanese (ja)
Other versions
JPS6136756B2 (en
Inventor
Masaji Kasai
Kazumichi Kono
Kimikatsu Shirahata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2675179A priority Critical patent/JPS55120586A/en
Publication of JPS55120586A publication Critical patent/JPS55120586A/en
Publication of JPS6136756B2 publication Critical patent/JPS6136756B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Mitomycins of formula I (X is alkoxy or amino; R is sulfonyl).
EXAMPLE: 10-Decarbamoyl-10-methanesulfonylporfiromycin.
USE: Synthetic intermediate of antitumor agents, mitomycins.
PROCESS: The objective compound I is prepared by reacting a compound II with a sulfonylation agent (e.g. p-toluenesulfonic acid chloride, methanesulfonic acid chloride, etc.) in an inert solvent (e.g. anhydrous ethyl ether, THF, etc.) in the presence of a base (e.g. sodium carbonate, pyridine, etc.) at -78W+30°C.
COPYRIGHT: (C)1980,JPO&Japio
JP2675179A 1979-03-09 1979-03-09 Novel mitomycins and their preparation Granted JPS55120586A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2675179A JPS55120586A (en) 1979-03-09 1979-03-09 Novel mitomycins and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2675179A JPS55120586A (en) 1979-03-09 1979-03-09 Novel mitomycins and their preparation

Publications (2)

Publication Number Publication Date
JPS55120586A true JPS55120586A (en) 1980-09-17
JPS6136756B2 JPS6136756B2 (en) 1986-08-20

Family

ID=12201985

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2675179A Granted JPS55120586A (en) 1979-03-09 1979-03-09 Novel mitomycins and their preparation

Country Status (1)

Country Link
JP (1) JPS55120586A (en)

Also Published As

Publication number Publication date
JPS6136756B2 (en) 1986-08-20

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