JPS5497692A - Linear mannan - Google Patents

Linear mannan

Info

Publication number
JPS5497692A
JPS5497692A JP421478A JP421478A JPS5497692A JP S5497692 A JPS5497692 A JP S5497692A JP 421478 A JP421478 A JP 421478A JP 421478 A JP421478 A JP 421478A JP S5497692 A JPS5497692 A JP S5497692A
Authority
JP
Japan
Prior art keywords
water
cells
treatment
dialyzed
precipitated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP421478A
Other languages
Japanese (ja)
Inventor
Masuko Suzuki
Shigeo Suzuki
Tatsuji Matsumoto
Takeshi Mikami
Yoshio Okawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP421478A priority Critical patent/JPS5497692A/en
Publication of JPS5497692A publication Critical patent/JPS5497692A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To prepare linear mannan useful as an injection for treatment of malignant tumor, free of a phosphoric acid group and proteins and having excellent anti- tumor activity, by extracting saccharomyces yeast cells, and separating and purifying the extract.
CONSTITUTION: A saccharomyces yeast, e.g. Saccharomyces cerevisiae, etc., is cultured, and the cultured cells are taken out, e.g. by centrifugal separation, etc., and washed. The cells are extracted with hot water at 100W150°C, and the extract is dialyzed and concentrated; crude polysaccharide is precipitated by adding a water-soluble solvent, e.g. ethanol, etc., to the concentrate. The polysaccharide is treated with Fehling's solution, etc., subsequently with a strong acid-type ion exchange resin, thereafter neutralized with a base, e.g. sodium carbonate, etc., concentrated, and dialyzed in flowing water. After the protein-removing treatment, the product is precipitated in a water-soluble solvent and filtrated. The desired neutral linear mannan is prepared by a column chromatography treatment of the aobove products.
COPYRIGHT: (C)1979,JPO&Japio
JP421478A 1978-01-20 1978-01-20 Linear mannan Pending JPS5497692A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP421478A JPS5497692A (en) 1978-01-20 1978-01-20 Linear mannan

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP421478A JPS5497692A (en) 1978-01-20 1978-01-20 Linear mannan

Publications (1)

Publication Number Publication Date
JPS5497692A true JPS5497692A (en) 1979-08-01

Family

ID=11578362

Family Applications (1)

Application Number Title Priority Date Filing Date
JP421478A Pending JPS5497692A (en) 1978-01-20 1978-01-20 Linear mannan

Country Status (1)

Country Link
JP (1) JPS5497692A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4216C1 (en) * 2012-08-15 2013-11-30 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Strain of Saccharomyces cerevisiae yeast - producer of mannans

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4216C1 (en) * 2012-08-15 2013-11-30 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Strain of Saccharomyces cerevisiae yeast - producer of mannans

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