JPS5473785A - 2-alkyl-4-trimethyl-5-fluorouracil - Google Patents
2-alkyl-4-trimethyl-5-fluorouracilInfo
- Publication number
- JPS5473785A JPS5473785A JP13783077A JP13783077A JPS5473785A JP S5473785 A JPS5473785 A JP S5473785A JP 13783077 A JP13783077 A JP 13783077A JP 13783077 A JP13783077 A JP 13783077A JP S5473785 A JPS5473785 A JP S5473785A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- formula
- alkyl
- trimethylsilyl
- trimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An 2-alkyl-4-trimethylsilyl-5-fluorouracil of formula II: (R is 1W 4C straight or branched chain alkyl group).
EXAMPLE: 2-Methyl-4-trimethylsilyl-5-fluorouracil.
USE: An intermediate for synthesis of medicines, particularly intermediate for N1-(2-tetra hydrofuryl)-5-fluorouracil useful as an anticarcinogen.
PROCESS: An 2-alkyl-5-fluorouracil of formula II is reacted with hexamethyldisilazane at a molar ratio of 1:0.5W2 at 140W170°C for 1W10 hr, and the excess hyxamethyldisilazane is distilled away under vacuum to give the compound of formula I. The N1-(2-tetrahydrofuryl)-5-fluorouracil can be obtained by reacting formula I with a 2-substituted tetrahydrofuran of formula III: (A is halogen, acyloxy group, etc.).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13783077A JPS5473785A (en) | 1977-11-18 | 1977-11-18 | 2-alkyl-4-trimethyl-5-fluorouracil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13783077A JPS5473785A (en) | 1977-11-18 | 1977-11-18 | 2-alkyl-4-trimethyl-5-fluorouracil |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5473785A true JPS5473785A (en) | 1979-06-13 |
JPS618837B2 JPS618837B2 (en) | 1986-03-18 |
Family
ID=15207828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13783077A Granted JPS5473785A (en) | 1977-11-18 | 1977-11-18 | 2-alkyl-4-trimethyl-5-fluorouracil |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5473785A (en) |
-
1977
- 1977-11-18 JP JP13783077A patent/JPS5473785A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS618837B2 (en) | 1986-03-18 |
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