JPS5473785A - 2-alkyl-4-trimethyl-5-fluorouracil - Google Patents

2-alkyl-4-trimethyl-5-fluorouracil

Info

Publication number
JPS5473785A
JPS5473785A JP13783077A JP13783077A JPS5473785A JP S5473785 A JPS5473785 A JP S5473785A JP 13783077 A JP13783077 A JP 13783077A JP 13783077 A JP13783077 A JP 13783077A JP S5473785 A JPS5473785 A JP S5473785A
Authority
JP
Japan
Prior art keywords
fluorouracil
formula
alkyl
trimethylsilyl
trimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13783077A
Other languages
Japanese (ja)
Other versions
JPS618837B2 (en
Inventor
Yasuo Hoshiide
Yoshio Hashimoto
Hiroshi Ogawa
Kenichi Suzuki
Takeji Seki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Original Assignee
NIKKEN KAGAKU KK
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIKKEN KAGAKU KK, Nikken Chemicals Co Ltd filed Critical NIKKEN KAGAKU KK
Priority to JP13783077A priority Critical patent/JPS5473785A/en
Publication of JPS5473785A publication Critical patent/JPS5473785A/en
Publication of JPS618837B2 publication Critical patent/JPS618837B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:An 2-alkyl-4-trimethylsilyl-5-fluorouracil of formula II: (R is 1W 4C straight or branched chain alkyl group).
EXAMPLE: 2-Methyl-4-trimethylsilyl-5-fluorouracil.
USE: An intermediate for synthesis of medicines, particularly intermediate for N1-(2-tetra hydrofuryl)-5-fluorouracil useful as an anticarcinogen.
PROCESS: An 2-alkyl-5-fluorouracil of formula II is reacted with hexamethyldisilazane at a molar ratio of 1:0.5W2 at 140W170°C for 1W10 hr, and the excess hyxamethyldisilazane is distilled away under vacuum to give the compound of formula I. The N1-(2-tetrahydrofuryl)-5-fluorouracil can be obtained by reacting formula I with a 2-substituted tetrahydrofuran of formula III: (A is halogen, acyloxy group, etc.).
COPYRIGHT: (C)1979,JPO&Japio
JP13783077A 1977-11-18 1977-11-18 2-alkyl-4-trimethyl-5-fluorouracil Granted JPS5473785A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13783077A JPS5473785A (en) 1977-11-18 1977-11-18 2-alkyl-4-trimethyl-5-fluorouracil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13783077A JPS5473785A (en) 1977-11-18 1977-11-18 2-alkyl-4-trimethyl-5-fluorouracil

Publications (2)

Publication Number Publication Date
JPS5473785A true JPS5473785A (en) 1979-06-13
JPS618837B2 JPS618837B2 (en) 1986-03-18

Family

ID=15207828

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13783077A Granted JPS5473785A (en) 1977-11-18 1977-11-18 2-alkyl-4-trimethyl-5-fluorouracil

Country Status (1)

Country Link
JP (1) JPS5473785A (en)

Also Published As

Publication number Publication date
JPS618837B2 (en) 1986-03-18

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