JPS5470253A - 17 alphaa*33iodobenzoyloxy**9 alphaachlorr 44pregnenee3*200dione*its ddhomooanalogues* manufacture of said compound and deinflammatory medicine containing said compound - Google Patents

17 alphaa*33iodobenzoyloxy**9 alphaachlorr 44pregnenee3*200dione*its ddhomooanalogues* manufacture of said compound and deinflammatory medicine containing said compound

Info

Publication number
JPS5470253A
JPS5470253A JP12954978A JP12954978A JPS5470253A JP S5470253 A JPS5470253 A JP S5470253A JP 12954978 A JP12954978 A JP 12954978A JP 12954978 A JP12954978 A JP 12954978A JP S5470253 A JPS5470253 A JP S5470253A
Authority
JP
Japan
Prior art keywords
compound
deinflammatory
ddhomooanalogues
alphaachlorr
200dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12954978A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6227076B2 (en, 2012
Inventor
Kerupu Ururitsuhi
Shiyutaanke Manfuuto
Buiiheruto Ruudorufu
Arihi Reo
Fuyurusuto Andooru
Miyuraa Maruseru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772748443 external-priority patent/DE2748443A1/de
Priority claimed from DE2748442A external-priority patent/DE2748442C3/de
Application filed by Schering AG filed Critical Schering AG
Publication of JPS5470253A publication Critical patent/JPS5470253A/ja
Publication of JPS6227076B2 publication Critical patent/JPS6227076B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP12954978A 1977-10-26 1978-10-23 17 alphaa*33iodobenzoyloxy**9 alphaachlorr 44pregnenee3*200dione*its ddhomooanalogues* manufacture of said compound and deinflammatory medicine containing said compound Granted JPS5470253A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772748443 DE2748443A1 (de) 1977-10-26 1977-10-26 17alpha-(3-jodbenzoyloxy)-9alpha- chlor-d-homo-4-pregnen-3.20-dione und verfahren zu ihrer herstellung
DE2748442A DE2748442C3 (de) 1977-10-26 1977-10-26 17α-(3-Jodbenzoyloxy)-9α -chlor4-pregnen-3.20-dione, Zwischenprodukte und Verfahren zu ihrer Herstellung, 9α -chlor-17α, 21-dihydroxy-1,4-pregnadien-3,20-dion und dieses enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
JPS5470253A true JPS5470253A (en) 1979-06-05
JPS6227076B2 JPS6227076B2 (en, 2012) 1987-06-12

Family

ID=25772982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12954978A Granted JPS5470253A (en) 1977-10-26 1978-10-23 17 alphaa*33iodobenzoyloxy**9 alphaachlorr 44pregnenee3*200dione*its ddhomooanalogues* manufacture of said compound and deinflammatory medicine containing said compound

Country Status (6)

Country Link
EP (1) EP0001737B1 (en, 2012)
JP (1) JPS5470253A (en, 2012)
BG (1) BG28719A3 (en, 2012)
DD (1) DD138981A5 (en, 2012)
DK (1) DK145666C (en, 2012)
HU (1) HU177759B (en, 2012)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63501292A (ja) * 1985-10-23 1988-05-19 アルコン・ラボラトーリーズ，インコーポレイテッド テトラヒドロ脈管形成抑制ステロイド
US10646497B2 (en) 2014-10-08 2020-05-12 Cosmo Technologies Limited 17α-monoesters and 17α,21-diesters of cortexolone for use in the treatment of tumors

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252729A (en) * 1978-05-12 1981-02-24 Hoffmann-La Roche Inc. Steroids and process for their manufacture
US4197406A (en) * 1978-05-12 1980-04-08 Hoffmann-La Roche Inc. D-Homosteroids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1081888B (de) * 1956-12-31 1960-05-19 Searle & Co Verfahren zur Herstellung von ?-3-Keto-9 ª‡-halogensteroiden

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63501292A (ja) * 1985-10-23 1988-05-19 アルコン・ラボラトーリーズ，インコーポレイテッド テトラヒドロ脈管形成抑制ステロイド
US10646497B2 (en) 2014-10-08 2020-05-12 Cosmo Technologies Limited 17α-monoesters and 17α,21-diesters of cortexolone for use in the treatment of tumors
US10993949B2 (en) 2014-10-08 2021-05-04 Cosmo Technologies Limited 17α-monoesters and 17α,21-diesters of cortexolone for use in the treatment of tumors
US11712443B2 (en) 2014-10-08 2023-08-01 Cosmo Technologies Limited 17α-monoesters and 17α,21-diesters of cortexolone for use in the treatment of tumors

Also Published As

Publication number Publication date
EP0001737B1 (de) 1981-01-07
HU177759B (en) 1981-12-28
DK145666B (da) 1983-01-17
EP0001737A1 (de) 1979-05-16
DK145666C (da) 1983-07-18
JPS6227076B2 (en, 2012) 1987-06-12
BG28719A3 (en) 1980-06-16
DD138981A5 (de) 1979-12-05
DK477778A (da) 1979-04-27

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