JPS54160359A - Preparation of coriolin - Google Patents

Preparation of coriolin

Info

Publication number
JPS54160359A
JPS54160359A JP6781478A JP6781478A JPS54160359A JP S54160359 A JPS54160359 A JP S54160359A JP 6781478 A JP6781478 A JP 6781478A JP 6781478 A JP6781478 A JP 6781478A JP S54160359 A JPS54160359 A JP S54160359A
Authority
JP
Japan
Prior art keywords
coriolin
derivative
formula
dihydrocoriolin
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6781478A
Other languages
Japanese (ja)
Inventor
Hamao Umezawa
Sumio Umezawa
Osamu Tsuchiya
Tomio Takeuchi
Yoshio Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP6781478A priority Critical patent/JPS54160359A/en
Publication of JPS54160359A publication Critical patent/JPS54160359A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: To obtain a large amount of coriolin useful as carcinostatics and antibacterials, by oxidizing a dihydrocoriolin prepared from its derivative through a protected derivative of naturally occurring coriolin B in large quantities.
CONSTITUTION: Coriolin B is reacted with 2,3-dihydropyran in the presence of an acid catalyst, e.g. p-toluene sulfonic acid, to form a coriolin B derivative of formula I: (R is hydroxyl-protecting group), which is then reacted with an alkali, e.g. sodium methoxide, to give a dihydrocoriolin derivative of formula II. The hydroxyl- protecting groups are removed from the derivative of formula II, and oxidized by an oxidizing agent in a solvent, e.g. benzene, to afford the objective compound of formula III. Dimethyl sulfoxide, dicyclohexylcarbodiimide etc. may be used as the oxidizing agent.
COPYRIGHT: (C)1979,JPO&Japio
JP6781478A 1978-06-07 1978-06-07 Preparation of coriolin Pending JPS54160359A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6781478A JPS54160359A (en) 1978-06-07 1978-06-07 Preparation of coriolin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6781478A JPS54160359A (en) 1978-06-07 1978-06-07 Preparation of coriolin

Publications (1)

Publication Number Publication Date
JPS54160359A true JPS54160359A (en) 1979-12-19

Family

ID=13355780

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6781478A Pending JPS54160359A (en) 1978-06-07 1978-06-07 Preparation of coriolin

Country Status (1)

Country Link
JP (1) JPS54160359A (en)

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