JPS54141788A - Preparation of nucleoside sulfate - Google Patents
Preparation of nucleoside sulfateInfo
- Publication number
- JPS54141788A JPS54141788A JP4782278A JP4782278A JPS54141788A JP S54141788 A JPS54141788 A JP S54141788A JP 4782278 A JP4782278 A JP 4782278A JP 4782278 A JP4782278 A JP 4782278A JP S54141788 A JPS54141788 A JP S54141788A
- Authority
- JP
- Japan
- Prior art keywords
- nucleoside
- sulfate
- intermediates
- moles
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound useful as biochemical reagents, medicines, and intermediates for their synthesis, by sulfating nucleoside with inexpensive and easily handleable specific sulfating agent and solvent.
CONSTITUTION: One mole of a nucleoside, e.g. a denosine or guanosine, is reacted with 5W15 moles of a pyrosulfate, a hydrogensulfate and/or sulfuric acid in 120W 200 moles of an amide solvent to give a nucleoside sulfate. Preferably, formamide or DMF may be used as the amide solvent; potassium pyrosulfate, as the sulfating agent.
USE: Intermediates for the synthesis of antiprotozoan agents or carcinostatics, capable of stabilizing an unstable medicine, e.g. S-adenosyl-L-methionine, by forming a complex with it.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4782278A JPS54141788A (en) | 1978-04-24 | 1978-04-24 | Preparation of nucleoside sulfate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4782278A JPS54141788A (en) | 1978-04-24 | 1978-04-24 | Preparation of nucleoside sulfate |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54141788A true JPS54141788A (en) | 1979-11-05 |
JPS6220195B2 JPS6220195B2 (en) | 1987-05-06 |
Family
ID=12786039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4782278A Granted JPS54141788A (en) | 1978-04-24 | 1978-04-24 | Preparation of nucleoside sulfate |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54141788A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS463367A (en) * | 1970-03-25 | 1971-10-29 | ||
JPS5126882A (en) * | 1974-08-21 | 1976-03-05 | Yamasa Shoyu Kk | Nukureoshido 55 monosurupponsanesuteruno seizoho |
-
1978
- 1978-04-24 JP JP4782278A patent/JPS54141788A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS463367A (en) * | 1970-03-25 | 1971-10-29 | ||
JPS5126882A (en) * | 1974-08-21 | 1976-03-05 | Yamasa Shoyu Kk | Nukureoshido 55 monosurupponsanesuteruno seizoho |
Also Published As
Publication number | Publication date |
---|---|
JPS6220195B2 (en) | 1987-05-06 |
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